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Pramel1 PRAME like 1 [ Mus musculus (house mouse) ]

Gene ID: 83491, updated on 2-Nov-2024

Summary

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Official Symbol
Pramel1provided by MGI
Official Full Name
PRAME like 1provided by MGI
Primary source
MGI:MGI:1890541
See related
Ensembl:ENSMUSG00000041805 AllianceGenome:MGI:1890541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 4.4) See more
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Genomic context

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See Pramel1 in Genome Data Viewer
Location:
4 E1; 4 77.64 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (143120889..143126730)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (143394441..143399819)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 38 Neighboring gene Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_11972 Neighboring gene PRAME like 12 Neighboring gene oogenesin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis. Yang M, et al. Development, 2023 Nov 1. PMID 37781892
  2. Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse. Mistry BV, et al. PLoS One, 2013. PMID 23565261, Free PMC Article
  3. Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte. Dadé S, et al. FEBS Lett, 2003 Dec 18. PMID 14675769
  4. An abundance of X-linked genes expressed in spermatogonia. Wang PJ, et al. Nat Genet, 2001 Apr. PMID 11279525
  5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.
    Title: Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
preferentially expressed antigen in melanoma-like protein 1
Names
preferentially expressed antigen in melanoma-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031377.2 → NP_113554.1  preferentially expressed antigen in melanoma-like protein 1

    See identical proteins and their annotated locations for NP_113554.1

    Status: VALIDATED

    Source sequence(s)
    AL611930
    Consensus CDS
    CCDS18888.1
    UniProtKB/Swiss-Prot
    Q99MW3
    Related
    ENSMUSP00000043718.4, ENSMUST00000037419.4
    Conserved Domains (1) summary
    sd00034
    Location:293 → 319
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    143120889..143126730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164575.1 → XP_036020468.1  preferentially expressed antigen in melanoma-like protein 1 isoform X1

    Conserved Domains (2) summary
    sd00033
    Location:230 → 255
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:227 → 360
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MW3.1 GenPept UniProtKB/Swiss-Prot:Q99MW3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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