U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tsc22d3 TSC22 domain family, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83514, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Tsc22d3provided by RGD
Official Full Name
TSC22 domain family, member 3provided by RGD
Primary source
RGD:621654
See related
EnsemblRapid:ENSRNOG00000056135 AllianceGenome:RGD:621654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gilz; Dsipi
Summary
Involved in body fluid secretion. Predicted to be located in nucleus. Orthologous to human TSC22D3 (TSC22 domain family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 469.6), Adrenal (RPKM 399.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tsc22d3 in Genome Data Viewer
Location:
Xq32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (109006410..109066389, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (104217898..104277886, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (111884285..111944693, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 3 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 Neighboring gene ribosomal protein L23a, pseudogene 9 Neighboring gene U6 spliceosomal RNA Neighboring gene midline 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Glucocorticoid-induced leucine zipper protects noise-induced apoptosis in cochlear cells by inhibiting endoplasmic reticulum stress in rats. Jia H, et al. Med Mol Morphol, 2020 Jun. PMID 31485805
  2. Glucocorticoid-Induced Leucine Zipper Protects the Retina From Light-Induced Retinal Degeneration by Inducing Bcl-xL in Rats. Gu R, et al. Invest Ophthalmol Vis Sci, 2017 Jul 1. PMID 28728173
  3. Roles of GILZ in protein metabolism of L6 muscle cells exposed to serum from septic rats. Xiong J, et al. Genet Mol Res, 2014 Oct 8. PMID 25299205
  4. Delta sleep-inducing peptide blocks excitatory effects of glutamate on rat brain neurons. Umriukhin PE. Bull Exp Biol Med, 2002 Jul. PMID 12459854
  5. Expression of glucocorticoid-induced leucine zipper (GILZ) in cardiomyocytes. Aguilar DC, et al. Cardiovasc Toxicol, 2013 Jun. PMID 23090754, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glucocorticoid-induced leucine zipper protects noise-induced apoptosis in cochlear cells by inhibiting endoplasmic reticulum stress in rats.
    Title: Glucocorticoid-induced leucine zipper protects noise-induced apoptosis in cochlear cells by inhibiting endoplasmic reticulum stress in rats.
  2. Overexpression of GILZ by OE-GILZ-rLV transduction protected the retina from light-induced cellular damage by activating antiapoptotic pathways.
    Title: Glucocorticoid-Induced Leucine Zipper Protects the Retina From Light-Induced Retinal Degeneration by Inducing Bcl-xL in Rats.
  3. GILZ may be sensitive to the elevated expression of GC in septic muscle, promoting the expression and activation of GR involved in GC/GR-mediated proteolysis in septic skeletal muscle.
    Title: Roles of GILZ in protein metabolism of L6 muscle cells exposed to serum from septic rats.
  4. Our data demonstrate GILZ induction in cardiomyocytes both in vivo and in vitro by glucocorticoids, pointing to H9c2(2-1) cells as a valid model for studying the biological function of GILZ in cardiomyocytes.
    Title: Expression of glucocorticoid-induced leucine zipper (GILZ) in cardiomyocytes.
  5. the delta sleep-inducing peptide effect on c-Fos gene expression might be mediated by NMDA-receptors.
    Title: Dizocilpine and cycloheximide prevent inhibition of c-Fos gene expression by delta sleep-inducing peptide in the paraventricular nucleus of the hypothalamus in rats with different resistance to emotional stress.
  6. GILZ has an important role not only in adjusting adaptive responses to hypoxia by negatively regulating the activation of macrophages and the expression of proinflammatory cytokines
    Title: Upregulations of glucocorticoid-induced leucine zipper by hypoxia and glucocorticoid inhibit proinflammatory cytokines under hypoxic conditions in macrophages.
  7. In PC12 cells, dexamethasone treatment leads to a progressive increase of GILZ mRNA expression levels via a glucocorticoid receptor-dependent mechanism.
    Title: Chromatin immunoprecipitation scanning identifies glucocorticoid receptor binding regions in the proximal promoter of a ubiquitously expressed glucocorticoid target gene in brain.
  8. multiple GILZ isoforms are expressed in most cells and tissues and that these play distinct roles in regulating proliferation and ion transport.
    Title: Differential activities of glucocorticoid-induced leucine zipper protein isoforms.
  9. a role in blocking excitatory effects of glutamate on rat brain neurons
    Title: Delta sleep-inducing peptide blocks excitatory effects of glutamate on rat brain neurons.
  10. Induction of GILZ mRNA may play a permissive role in the enhancement of the early and/or late responses; these effects may be necessary for a full response but do not by themselves promote early changes in urinary Na(+) and K(+) excretion.
    Title: Mineralocorticoid effects in the kidney: correlation between alphaENaC, GILZ, and Sgk-1 mRNA expression and urinary excretion of Na+ and K+.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in body fluid secretion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of activation-induced cell death of T cells IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of activation-induced cell death of T cells IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of activation-induced cell death of T cells ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in response to osmotic stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TSC22 domain family protein 3
Names
TSC22 domain family 3
delta sleep inducing peptide, immunoreactor
glucocorticoid-induced leucine zipper protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400982.1 → NP_001387911.1  TSC22 domain family protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I5ZQF5
    Conserved Domains (1) summary
    cd21940
    Location:122 → 199
    ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3

  2. NM_001400983.1 → NP_001387912.1  TSC22 domain family protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I5ZQF5
    Conserved Domains (1) summary
    cd21940
    Location:122 → 199
    ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3

  3. NM_031345.2 → NP_112635.1  TSC22 domain family protein 3 isoform 2

    See identical proteins and their annotated locations for NP_112635.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q9EQZ1
    UniProtKB/TrEMBL
    A6HLR6
    Related
    ENSRNOP00000072713.1, ENSRNOT00000085118.3
    Conserved Domains (1) summary
    pfam01166
    Location:58 → 114
    TSC22; TSC-22/dip/bun family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    109006410..109066389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008773447.4 → XP_008771669.1  TSC22 domain family protein 3 isoform X1

    See identical proteins and their annotated locations for XP_008771669.1

    UniProtKB/TrEMBL
    A0A8I5ZQF5
    Conserved Domains (1) summary
    cd21940
    Location:122 → 199
    ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3

  2. XM_006234249.5 → XP_006234311.1  TSC22 domain family protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006234311.1

    UniProtKB/TrEMBL
    A0A8I5ZQF5
    Conserved Domains (1) summary
    cd21940
    Location:122 → 199
    ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3

  3. XM_063280331.1 → XP_063136401.1  TSC22 domain family protein 3 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQZ1.1 GenPept UniProtKB/Swiss-Prot:Q9EQZ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools