Pex3 peroxisomal biogenesis factor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pex3provided by RGD
Official Full Name: peroxisomal biogenesis factor 3provided by RGD
Primary source: RGD:621636
See related: EnsemblRapid:ENSRNOG00000015660 AllianceGenome:RGD:621636
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable lipid binding activity and protein-macromolecule adaptor activity. Involved in peroxisome membrane biogenesis. Located in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 10B and peroxisome biogenesis disorder 10A. Orthologous to human PEX3 (peroxisomal biogenesis factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 102.6), Heart (RPKM 92.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (9732641..9774479, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (7912508..7954474, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (7685209..7726238, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141589 (e-PCR)
- UniSTS:223583

RH142832 (e-PCR)
- UniSTS:232079

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in peroxisome membrane biogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in peroxisome organization	IEA Inferred from Electronic Annotation more info
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into peroxisome membrane	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	TAS Traceable Author Statement more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-lipid complex	IEA Inferred from Electronic Annotation more info
part_of protein-lipid complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisomal biogenesis factor 3

Names: peroxin-3; peroxisomal assembly protein PEX3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031350.2 → NP_112640.1 peroxisomal biogenesis factor 3

See identical proteins and their annotated locations for NP_112640.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9JJK4

UniProtKB/TrEMBL

A0A8I6AUP3, A6JP61

Conserved Domains (1) summary

pfam04882
Location:11 → 361

Peroxin-3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

9732641..9774479 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092495.2 → XP_038948423.1 peroxisomal biogenesis factor 3 isoform X2

UniProtKB/TrEMBL

A0A8I6AUP3, A0A8L2QAW4

Conserved Domains (1) summary

pfam04882
Location:11 → 359

Peroxin-3
XM_039092487.2 → XP_038948415.1 peroxisomal biogenesis factor 3 isoform X1

UniProtKB/TrEMBL

A0A8I6AUP3

Related

ENSRNOP00000021524.4, ENSRNOT00000021524.6

Conserved Domains (1) summary

pfam04882
Location:11 → 347

Peroxin-3