Vdac2 voltage-dependent anion channel 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vdac2provided by RGD
Official Full Name: voltage-dependent anion channel 2provided by RGD
Primary source: RGD:621576
See related: EnsemblRapid:ENSRNOG00000013505 AllianceGenome:RGD:621576
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including phosphatidylcholine binding activity; phospholipid scramblase activity; and sterol binding activity. Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; mitochondrial outer membrane permeabilization; and negative regulation of intrinsic apoptotic signaling pathway. Located in synaptic vesicle. Used to study myocardial infarction and visual epilepsy. Biomarker of temporal lobe epilepsy. Orthologous to human VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 1816.1), Muscle (RPKM 1538.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (2512214..2526105, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (2462877..2476802, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (2634622..2648548, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Paclitaxel increased both alpha- and betaII-tubulin-VDAC2 interactions.
Title: Altered skeletal muscle microtubule-mitochondrial VDAC2 binding is related to bioenergetic impairments after paclitaxel but not vinblastine chemotherapies.
the coupling of VDAC2 with RyR2 is essential for Ca2+ transfer from the sarcoplasmic reticulum to mitochondria in the heart.
Title: Coupling of ryanodine receptor 2 and voltage-dependent anion channel 2 is essential for Ca²+ transfer from the sarcoplasmic reticulum to the mitochondria in the heart.
Multiple spots on 2D gel representing VDAC2 protein forms with different isoelectric points.
Title: Relationship between expression of voltage-dependent anion channel (VDAC) isoforms and type of hexokinase binding sites on brain mitochondria.
Up-regulation of VDAC1 and down-regulation of VDAC2 may participate in hippocampal neuron injury induced by zinc deficiency.
Title: Effects of intracellular zinc depletion on the expression of VDAC in cultured hippocampal neurons.
Results describe the expression of voltage-dependent anion channel isoforms in rat, bovine, and chicken brain mitochondria, and suggest that the nature of hexokinase binding site is not determined by the expression of a single VDAC isoform.
Title: Relationship between expression of voltage-dependent anion channel (VDAC) isoforms and type of hexokinase binding sites on brain mitochondria.
Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation.
Title: Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135028 (e-PCR)
- UniSTS:218305

AA900297 (e-PCR)
- UniSTS:248807

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ceramide binding	ISO Inferred from Sequence Orthology more info
enables ceramide binding	ISS Inferred from Sequence or Structural Similarity more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxysterol binding	ISO Inferred from Sequence Orthology more info
enables oxysterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables porin activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial outer membrane permeabilization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial outer membrane permeabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein polymerization	ISO Inferred from Sequence Orthology more info
involved_in phospholipid translocation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of pore complex	IEA Inferred from Electronic Annotation more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: voltage-dependent anion-selective channel protein 2

Names: B36-VDAC; VDAC-2; outer mitochondrial membrane protein porin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031354.1 → NP_112644.1 voltage-dependent anion-selective channel protein 2

See identical proteins and their annotated locations for NP_112644.1

Status: PROVISIONAL

Source sequence(s)

AB039663

UniProtKB/Swiss-Prot

P81155, Q9JI32

UniProtKB/TrEMBL

A0A8L2URG2

Related

ENSRNOP00000018462.7, ENSRNOT00000018462.8

Conserved Domains (1) summary

cd07306
Location:16 → 294

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

2512214..2526105 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251661.4 → XP_006251723.1 voltage-dependent anion-selective channel protein 2 isoform X1

See identical proteins and their annotated locations for XP_006251723.1

UniProtKB/Swiss-Prot

P81155, Q9JI32

UniProtKB/TrEMBL

A0A8L2URG2

Conserved Domains (1) summary

cd07306
Location:16 → 294

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane