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Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83588, updated on 10-Jul-2024

Summary

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Official Symbol
Kcns3provided by RGD
Official Full Name
potassium voltage-gated channel, modifier subfamily S, member 3provided by RGD
Primary source
RGD:621527
See related
EnsemblRapid:ENSRNOG00000004899 AllianceGenome:RGD:621527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Orthologous to human KCNS3 (potassium voltage-gated channel modifier subfamily S member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 121.7), Brain (RPKM 41.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kcns3 in Genome Data Viewer
Location:
6q15
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (39527410..39584105, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (33808314..33865018, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (36764040..36819810, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103513 Neighboring gene presenilin associated, rhomboid-like, pseudogene 7 Neighboring gene uncharacterized LOC102547959 Neighboring gene mesogenin 1 Neighboring gene GEN1 Holliday junction 5' flap endonuclease

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Different Kv2.1/Kv9.3 heteromer expression during brain and lung post-natal development in the rat. Coma M, et al. J Physiol Biochem, 2002 Dec. PMID 12744302
  2. Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain. Stocker M, et al. Biochem Biophys Res Commun, 1998 Jul 30. PMID 9704029
  3. Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. Patel AJ, et al. EMBO J, 1997 Nov 17. PMID 9362476, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily S member 3
Names
Shab-related delayed-rectifier K+ channel (Kv9.3)
delayed-rectifier K(+) channel alpha subunit 3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
voltage-gated potassium channel subunit Kv9.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389230.1 → NP_001376159.1  potassium voltage-gated channel subfamily S member 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    O54900, O88759
    UniProtKB/TrEMBL
    A6HAP0
    Related
    ENSRNOP00000105842.1, ENSRNOT00000152198.1
    Conserved Domains (2) summary
    cd18428
    Location:15 → 122
    BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
    pfam00520
    Location:184 → 417
    Ion_trans; Ion transport protein

  2. NM_031778.3 → NP_113966.2  potassium voltage-gated channel subfamily S member 3

    See identical proteins and their annotated locations for NP_113966.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    O54900, O88759
    UniProtKB/TrEMBL
    A6HAP0
    Related
    ENSRNOP00000102174.1, ENSRNOT00000133371.1
    Conserved Domains (2) summary
    cd18428
    Location:15 → 122
    BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
    pfam00520
    Location:184 → 417
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    39527410..39584105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112998.2 → XP_038968926.1  potassium voltage-gated channel subfamily S member 3 isoform X1

    UniProtKB/Swiss-Prot
    O54900, O88759
    UniProtKB/TrEMBL
    A6HAP0
    Conserved Domains (2) summary
    cd18428
    Location:15 → 122
    BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
    pfam00520
    Location:184 → 417
    Ion_trans; Ion transport protein

  2. XM_039112997.2 → XP_038968925.1  potassium voltage-gated channel subfamily S member 3 isoform X1

    UniProtKB/Swiss-Prot
    O54900, O88759
    UniProtKB/TrEMBL
    A6HAP0
    Related
    ENSRNOP00000080054.1, ENSRNOT00000108088.2
    Conserved Domains (2) summary
    cd18428
    Location:15 → 122
    BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
    pfam00520
    Location:184 → 417
    Ion_trans; Ion transport protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88759.1 GenPept UniProtKB/Swiss-Prot:O88759

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