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LAC17 laccase 17 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836124, updated on 18-Sep-2024

Summary

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Official Symbol
LAC17
Official Full Name
laccase 17
Primary source
TAIR:AT5G60020
Locus tag
AT5G60020
See related
Araport:AT5G60020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATLAC17; laccase 17; MMN10.20; MMN10_20
Summary
LAC17 appears to have laccase activity based on enzyme assays performed using lac17 mutants. Notably, these mutants appear to have a reduced deposition of G lignin units. LAC17 is expressed in interfascicular fibers and likely contributes to lignin biosynthesis, and hence, cell wall biosynthesis, there.
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Genomic context

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See LAC17 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (24167996..24170462)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ferric reductase-like transmembrane component family protein Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene nuclear RNA polymerase C1 Neighboring gene BTB/POZ domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of LACCASE4 and 17 results in tissue-specific alterations to lignification of Arabidopsis thaliana stems. Berthet S, et al. Plant Cell, 2011 Mar. PMID 21447792, Free PMC Article
  2. Laccase is necessary and nonredundant with peroxidase for lignin polymerization during vascular development in Arabidopsis. Zhao Q, et al. Plant Cell, 2013 Oct. PMID 24143805, Free PMC Article
  3. Laccases and Peroxidases Co-Localize in Lignified Secondary Cell Walls throughout Stem Development. Hoffmann N, et al. Plant Physiol, 2020 Oct. PMID 32699027, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Laccases and Peroxidases Co-Localize in Lignified Secondary Cell Walls throughout Stem Development.
    Title: Laccases and Peroxidases Co-Localize in Lignified Secondary Cell Walls throughout Stem Development.
  2. Simultaneous disruption of LAC11 along with LAC4 and LAC17 causes severe plant growth arrest, narrower root diameter, indehiscent anthers, and vascular development arrest with lack of lignification.
    Title: Laccase is necessary and nonredundant with peroxidase for lignin polymerization during vascular development in Arabidopsis.
  3. Disruption of LAC17 affects plant development, vascular tissues, lignification, and saccharification efficiency to various extents.
    Title: Disruption of LACCASE4 and 17 results in tissue-specific alterations to lignification of Arabidopsis thaliana stems.
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General gene information

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Homology

NM_001345382.1
NM_001345383.1
NM_125395.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydroquinone:oxygen oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lignin biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lignin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phenylpropanoid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in plant-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
laccase 17
NP_200810.1
  • laccase 17 (LAC17); FUNCTIONS IN: laccase activity; INVOLVED IN: oxidation reduction, lignin catabolic process; LOCATED IN: endomembrane system, apoplast; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, C globular stage, petal differentiation and expansion stage, LP.12 twelve leaves visible; CONTAINS InterPro DOMAIN/s: Multicopper oxidase, type 3 (InterPro:IPR011707), Laccase (InterPro:IPR017761), Multicopper oxidase, type 2 (InterPro:IPR011706), Cupredoxin (InterPro:IPR008972), Multicopper oxidase, copper-binding site (InterPro:IPR002355), Multicopper oxidase, type 1 (InterPro:IPR001117); BEST Arabidopsis thaliana protein match is: laccase 2 (TAIR:AT2G29130.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    24167996..24170462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125395.3 → NP_200810.1  laccase 17 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200810.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FJD5
    UniProtKB/TrEMBL
    A0A178UD34, A0A5S9YFP1, A0A7G2FLI9
    Conserved Domains (1) summary
    TIGR03389
    Location:22 → 577
    laccase; plant

  2. NM_001345382.1 → NP_001330990.1  laccase 17 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BCG5, A0A7G2FLI9

  3. NM_001345383.1 → NP_001330991.1  laccase 17 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BCH1, A0A7G2FLI9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FJD5.1

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