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LFY floral meristem identity control protein LEAFY (LFY) [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836307, updated on 18-Sep-2024

Summary

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Official Symbol
LFY
Official Full Name
floral meristem identity control protein LEAFY (LFY)
Primary source
TAIR:AT5G61850
Locus tag
AT5G61850
See related
Araport:AT5G61850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
LEAFY; LEAFY 3; LFY3; MAC9.13; MAC9_13
Summary
Encodes transcriptional regulator that promotes the transition to flowering.Involved in floral meristem development. LFY is involved in the regulation of AP3 expression, and appears to bring the F-box protein UFO to the AP3 promoter. Amino acids 46-120 define a protein domain that mediates self-interaction.
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Genomic context

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See LFY in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (24844248..24846989)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tRNA-Tyr Neighboring gene Exostosin family protein Neighboring gene uncharacterized protein Neighboring gene Protein Transporter, Pam16

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The LEAFY floral regulator displays pioneer transcription factor properties. Lai X, et al. Mol Plant, 2021 May 3. PMID 33684542
  2. Gibberellins promote flowering of arabidopsis by activating the LEAFY promoter. Blazquez MA, et al. Plant Cell, 1998 May. PMID 9596637, Free PMC Article
  3. A genetic framework for floral patterning. Parcy F, et al. Nature, 1998 Oct 8. PMID 9783581
  4. Transcriptional activation of APETALA1 by LEAFY. Wagner D, et al. Science, 1999 Jul 23. PMID 10417387
  5. Quantitative trait loci for floral morphology in Arabidopsis thaliana. Juenger T, et al. Genetics, 2000 Nov. PMID 11063709, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LEAFY and APETALA1 down-regulate ZINC FINGER PROTEIN 1 and 8 to release their repression on class B and C floral homeotic genes.
    Title: LEAFY and APETALA1 down-regulate ZINC FINGER PROTEIN 1 and 8 to release their repression on class B and C floral homeotic genes.
  2. The LEAFY floral regulator displays pioneer transcription factor properties.
    Title: The LEAFY floral regulator displays pioneer transcription factor properties.
  3. LEAFY is a pioneer transcription factor and licenses cell reprogramming to floral fate.
    Title: LEAFY is a pioneer transcription factor and licenses cell reprogramming to floral fate.
  4. LFY activity is fully dependent on BOP2 as well as on CUL3A and B to regulate target genes such as APETALA1 and to induce ectopic flower formation.
    Title: LEAFY activity is post-transcriptionally regulated by BLADE ON PETIOLE2 and CULLIN3 in Arabidopsis.
  5. LFY and AP1 are conserved floral regulators that act nonredundantly in C. hirsuta, such that LFY has more obvious roles in floral and leaf development in C. hirsuta than in A. thaliana.
    Title: Conservation vs divergence in LEAFY and APETALA1 functions between Arabidopsis thaliana and Cardamine hirsuta.
  6. LFY and AP1/CAL act as part of an incoherent feed-forward loop, a network motif where two interconnected pathways or transcription factors act in opposite directions on a target gene, to control the establishment of a stable developmental program for the formation of flowers.
    Title: Transcription Factor Interplay between LEAFY and APETALA1/CAULIFLOWER during Floral Initiation.
  7. WRKY71 activity hastens flowering via the direct activation of FT and LFY.
    Title: WRKY71 accelerates flowering via the direct activation of FLOWERING LOCUS T and LEAFY in Arabidopsis thaliana.
  8. data suggest that transcriptional regulation of LFY at the chromatin level by PKL may at least partially account for the late-flowering phenotype of pkl mutants
    Title: CHD3 chromatin-remodeling factor PICKLE regulates floral transition partially via modulating LEAFY expression at the chromatin level in Arabidopsis.
  9. ANT and AIL6 directly induce LFY expression in response to auxin to promote the onset of flower formation.
    Title: AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
  10. A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor.
    Title: A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_125579.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within floral meristem determinacy IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gibberellic acid mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within maintenance of inflorescence meristem identity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
floral meristem identity control protein LEAFY (LFY)
NP_200993.1
  • LEAFY (LFY); CONTAINS InterPro DOMAIN/s: Floricaula/leafy protein (InterPro:IPR002910); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    24844248..24846989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001345500.1 → NP_001331273.1  floral meristem identity control protein LEAFY (LFY) [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BDB4, A0A654GE89
    Conserved Domains (2) summary
    pfam01698
    Location:44 → 111
    LFY_SAM; Floricaula / Leafy protein SAM domain
    pfam17538
    Location:227 → 391
    C_LFY_FLO; DNA Binding Domain (C-terminal) Leafy/Floricaula

  2. NM_125579.1 → NP_200993.1  floral meristem identity control protein LEAFY (LFY) [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0MFR2, Q00958, Q1PDG5, Q8LSH2, Q8LSH3
    UniProtKB/TrEMBL
    A0A023T4L8, A0A178U799, A0A384L7U0
    Conserved Domains (2) summary
    pfam01698
    Location:44 → 111
    LFY_SAM; Floricaula / Leafy protein SAM domain
    pfam17538
    Location:223 → 387
    C_LFY_FLO; DNA Binding Domain (C-terminal) Leafy/Floricaula
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00958.2

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