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ZMIZ2 zinc finger MIZ-type containing 2 [ Homo sapiens (human) ]

Gene ID: 83637, updated on 2-Nov-2024

Summary

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Official Symbol
ZMIZ2provided by HGNC
Official Full Name
zinc finger MIZ-type containing 2provided by HGNC
Primary source
HGNC:HGNC:22229
See related
Ensembl:ENSG00000122515 MIM:611196; AllianceGenome:HGNC:22229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET27; ZIMP7; hZIMP7; TRAFIP20
Summary
ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]
Expression
Ubiquitous expression in spleen (RPKM 17.3), skin (RPKM 13.4) and 25 other tissues See more
Orthologs
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Genomic context

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See ZMIZ2 in Genome Data Viewer
Location:
7p13
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44748571..44769881)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (44909114..44930427)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44788170..44809480)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18147 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44646637-44647200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18148 Neighboring gene oxoglutarate dehydrogenase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25949 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:44674956-44675111 Neighboring gene OGDH intron CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25951 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:44679045-44679572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44685039-44685539 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:44717745-44717958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44740093-44740593 Neighboring gene uncharacterized LOC124901622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44794273-44794954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44807583-44808109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44826409-44826913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44826914-44827417 Neighboring gene uncharacterized LOC105375259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18154 Neighboring gene peptidylprolyl isomerase A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer. Gan X, et al. Cell Mol Biol Lett, 2024 Sep 12. PMID 39266996, Free PMC Article
  2. The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor. Lee J, et al. Nucleic Acids Res, 2007. PMID 17584785, Free PMC Article
  3. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Huang CY, et al. Mol Endocrinol, 2005 Dec. PMID 16051670
  4. A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. Peng Y, et al. J Biol Chem, 2010 Apr 9. PMID 20159969, Free PMC Article
  5. LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of β-catenin. Zhu Y, et al. Cell Death Differ, 2020 Apr. PMID 31527801, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer.
    Title: Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer.
  2. LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of beta-catenin.
    Title: LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of β-catenin.
  3. there is an interaction between Zimp7 and PIAS proteins with higher preference for PIAS3, in androgen receptor-mediated transcription
    Title: A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription.
  4. hZimp7 modulates androgen receptor and/or other nuclear receptor-mediated transcription, possibly through alteration of chromatin structure by SWI/SNF-like BAF complexes.
    Title: hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1886, DKFZp761I2123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nuclear replication fork IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger MIZ domain-containing protein 2
Names
PIAS-like protein Zimp7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300959.2 → NP_001287888.1  zinc finger MIZ domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001287888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice site and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AI494261, AK057378, AL831933, BC110435, HY060154
    Consensus CDS
    CCDS75591.1
    UniProtKB/TrEMBL
    D4YW75
    Related
    ENSP00000409648.1, ENST00000413916.5
    Conserved Domains (2) summary
    PHA03247
    Location:169 → 330
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:539 → 586
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  2. NM_031449.4 → NP_113637.3  zinc finger MIZ domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_113637.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest isoform (1).
    Source sequence(s)
    AC004859, AK090415, AK128359, AY426594, BI115680, CD367243
    Consensus CDS
    CCDS43576.1
    UniProtKB/Swiss-Prot
    A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7
    UniProtKB/TrEMBL
    D4YW75
    Related
    ENSP00000311778.4, ENST00000309315.9
    Conserved Domains (1) summary
    pfam02891
    Location:596 → 644
    zf-MIZ; MIZ/SP-RING zinc finger

  3. NM_174929.2 → NP_777589.2  zinc finger MIZ domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_777589.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK057378, AK090415, AL831933, AY426594, BC016968, BC021924, CD367243
    Consensus CDS
    CCDS43577.1
    UniProtKB/TrEMBL
    D4YW75
    Related
    ENSP00000265346.7, ENST00000265346.11
    Conserved Domains (1) summary
    pfam02891
    Location:570 → 618
    zf-MIZ; MIZ/SP-RING zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    44748571..44769881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420896.1 → XP_047276852.1  zinc finger MIZ domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7

  2. XM_047420891.1 → XP_047276847.1  zinc finger MIZ domain-containing protein 2 isoform X1

  3. XM_047420898.1 → XP_047276854.1  zinc finger MIZ domain-containing protein 2 isoform X3

  4. XM_047420902.1 → XP_047276858.1  zinc finger MIZ domain-containing protein 2 isoform X5

  5. XM_047420907.1 → XP_047276863.1  zinc finger MIZ domain-containing protein 2 isoform X8

  6. XM_005249866.3 → XP_005249923.1  zinc finger MIZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005249923.1

    UniProtKB/TrEMBL
    D4YW75
    Conserved Domains (1) summary
    pfam02891
    Location:605 → 653
    zf-MIZ; MIZ/SP-RING zinc finger

  7. XM_005249869.3 → XP_005249926.1  zinc finger MIZ domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005249926.1

    UniProtKB/Swiss-Prot
    A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7
    UniProtKB/TrEMBL
    D4YW75
    Related
    ENSP00000414723.1, ENST00000441627.5
    Conserved Domains (1) summary
    pfam02891
    Location:596 → 644
    zf-MIZ; MIZ/SP-RING zinc finger

  8. XM_005249870.3 → XP_005249927.1  zinc finger MIZ domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    D4YW75
    Conserved Domains (1) summary
    pfam02891
    Location:579 → 627
    zf-MIZ; MIZ/SP-RING zinc finger

  9. XM_005249872.3 → XP_005249929.1  zinc finger MIZ domain-containing protein 2 isoform X5

    See identical proteins and their annotated locations for XP_005249929.1

    UniProtKB/TrEMBL
    D4YW75
    Conserved Domains (1) summary
    pfam02891
    Location:570 → 618
    zf-MIZ; MIZ/SP-RING zinc finger

  10. XM_005249871.3 → XP_005249928.1  zinc finger MIZ domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    D4YW75
    Conserved Domains (1) summary
    pfam02891
    Location:573 → 621
    zf-MIZ; MIZ/SP-RING zinc finger

  11. XM_005249873.3 → XP_005249930.1  zinc finger MIZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    D4YW75, E7EWM3
    Conserved Domains (1) summary
    pfam02891
    Location:564 → 612
    zf-MIZ; MIZ/SP-RING zinc finger

  12. XM_047420895.1 → XP_047276851.1  zinc finger MIZ domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7

  13. XM_047420903.1 → XP_047276859.1  zinc finger MIZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    E7EWM3
    Related
    ENSP00000396601.1, ENST00000433667.5

  14. XM_047420892.1 → XP_047276848.1  zinc finger MIZ domain-containing protein 2 isoform X1

  15. XM_047420893.1 → XP_047276849.1  zinc finger MIZ domain-containing protein 2 isoform X1

  16. XM_017012674.2 → XP_016868163.1  zinc finger MIZ domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    D4YW75
    Conserved Domains (1) summary
    pfam02891
    Location:605 → 653
    zf-MIZ; MIZ/SP-RING zinc finger

  17. XM_047420897.1 → XP_047276853.1  zinc finger MIZ domain-containing protein 2 isoform X3

  18. XM_047420899.1 → XP_047276855.1  zinc finger MIZ domain-containing protein 2 isoform X5

  19. XM_047420904.1 → XP_047276860.1  zinc finger MIZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    E7EWM3

  20. XM_047420905.1 → XP_047276861.1  zinc finger MIZ domain-containing protein 2 isoform X7

  21. XM_047420906.1 → XP_047276862.1  zinc finger MIZ domain-containing protein 2 isoform X8

  22. XM_047420900.1 → XP_047276856.1  zinc finger MIZ domain-containing protein 2 isoform X5

  23. XM_005249867.6 → XP_005249924.1  zinc finger MIZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005249924.1

    UniProtKB/TrEMBL
    D4YW75
    Conserved Domains (1) summary
    pfam02891
    Location:605 → 653
    zf-MIZ; MIZ/SP-RING zinc finger

  24. XM_047420908.1 → XP_047276864.1  zinc finger MIZ domain-containing protein 2 isoform X9

  25. XM_011515566.2 → XP_011513868.1  zinc finger MIZ domain-containing protein 2 isoform X10

    UniProtKB/TrEMBL
    B3KR25
    Conserved Domains (1) summary
    pfam02891
    Location:331 → 379
    zf-MIZ; MIZ/SP-RING zinc finger

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    44909114..44930427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359128.1 → XP_054215103.1  zinc finger MIZ domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7

  2. XM_054359123.1 → XP_054215098.1  zinc finger MIZ domain-containing protein 2 isoform X1

  3. XM_054359127.1 → XP_054215102.1  zinc finger MIZ domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7

  4. XM_054359131.1 → XP_054215106.1  zinc finger MIZ domain-containing protein 2 isoform X3

  5. XM_054359136.1 → XP_054215111.1  zinc finger MIZ domain-containing protein 2 isoform X5

  6. XM_054359137.1 → XP_054215112.1  zinc finger MIZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    E7EWM3

  7. XM_054359142.1 → XP_054215117.1  zinc finger MIZ domain-containing protein 2 isoform X8

  8. XM_054359120.1 → XP_054215095.1  zinc finger MIZ domain-containing protein 2 isoform X1

  9. XM_054359126.1 → XP_054215101.1  zinc finger MIZ domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7

  10. XM_054359130.1 → XP_054215105.1  zinc finger MIZ domain-containing protein 2 isoform X3

  11. XM_054359134.1 → XP_054215109.1  zinc finger MIZ domain-containing protein 2 isoform X5

  12. XM_054359132.1 → XP_054215107.1  zinc finger MIZ domain-containing protein 2 isoform X4

  13. XM_054359138.1 → XP_054215113.1  zinc finger MIZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    E7EWM3

  14. XM_054359124.1 → XP_054215099.1  zinc finger MIZ domain-containing protein 2 isoform X1

  15. XM_054359125.1 → XP_054215100.1  zinc finger MIZ domain-containing protein 2 isoform X1

  16. XM_054359121.1 → XP_054215096.1  zinc finger MIZ domain-containing protein 2 isoform X1

  17. XM_054359135.1 → XP_054215110.1  zinc finger MIZ domain-containing protein 2 isoform X5

  18. XM_054359122.1 → XP_054215097.1  zinc finger MIZ domain-containing protein 2 isoform X1

  19. XM_054359129.1 → XP_054215104.1  zinc finger MIZ domain-containing protein 2 isoform X3

  20. XM_054359133.1 → XP_054215108.1  zinc finger MIZ domain-containing protein 2 isoform X5

  21. XM_054359139.1 → XP_054215114.1  zinc finger MIZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    E7EWM3

  22. XM_054359140.1 → XP_054215115.1  zinc finger MIZ domain-containing protein 2 isoform X7

  23. XM_054359141.1 → XP_054215116.1  zinc finger MIZ domain-containing protein 2 isoform X8

  24. XM_054359143.1 → XP_054215118.1  zinc finger MIZ domain-containing protein 2 isoform X9

  25. XM_054359144.1 → XP_054215119.1  zinc finger MIZ domain-containing protein 2 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NF64.2 GenPept UniProtKB/Swiss-Prot:Q8NF64

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