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Cnnm1 cyclin M1 [ Mus musculus (house mouse) ]

Gene ID: 83674, updated on 2-Nov-2024

Summary

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Official Symbol
Cnnm1provided by MGI
Official Full Name
cyclin M1provided by MGI
Primary source
MGI:MGI:1891366
See related
Ensembl:ENSMUSG00000025189 AllianceGenome:MGI:1891366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acdp1; CLP-1
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in magnesium ion homeostasis. Located in dendrite; neuronal cell body; and plasma membrane. Orthologous to human CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 15.2), cortex adult (RPKM 9.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Cnnm1 in Genome Data Viewer
Location:
19 C3; 19 36.67 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43427508..43485649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43439069..43497210)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene heparanase 2 Neighboring gene leucine zipper transcription factor-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46194 Neighboring gene predicted gene, 38568 Neighboring gene STARR-seq mESC enhancer starr_46196 Neighboring gene STARR-positive B cell enhancer mm9_chr19:43592413-43592714 Neighboring gene STARR-positive B cell enhancer ABC_E1525 Neighboring gene STARR-positive B cell enhancer ABC_E1213 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene glutamic-oxaloacetic transaminase 1, soluble

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of Cnnm1 and Its Association with Stemness, Cell Cycle, and Differentiation in Spermatogenic Cells in Mouse Testis. Chandran U, et al. Biol Reprod, 2016 Jul. PMID 27251091
  2. Ancient conserved domain protein-1 binds copper and modifies its retention in cells. Alderton A, et al. J Neurochem, 2007 Oct. PMID 17608643
  3. Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis. Guo D, et al. Mol Pain, 2005 Apr 19. PMID 15840172, Free PMC Article
  4. Molecular cloning and characterization of the mouse Acdp gene family. Wang CY, et al. BMC Genomics, 2004 Jan 15. PMID 14723793, Free PMC Article
  5. Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. Kasowitz SD, et al. PLoS Genet, 2018 May. PMID 29799838, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CNNM1 expression was restricted to c-KIT- and OCT3/4-positive cells in the testis, indicating that they are early spermatogonial cells. Spermatogonial stem cells in primary culture expressed Cnnm1, and their differentiation into embryoid body-like clusters in vitro resulted in the loss of Cnnm1 expression. Silencing of Cnnm1 in GC1-spg cells reduced number of cells in G1 phase with increased cells in S and G2/M phases.
    Title: Expression of Cnnm1 and Its Association with Stemness, Cell Cycle, and Differentiation in Spermatogenic Cells in Mouse Testis.
  2. We determined that ACDP-1 is a high affinity copper binding protein able to bind copper at nanomolar concentrations. In addition the promoter of ACDP-1 contains metal response elements and cellular expression of ACDP-1 alters cellular retention of copper.
    Title: Ancient conserved domain protein-1 binds copper and modifies its retention in cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in magnesium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in magnesium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metal transporter CNNM1
Names
ancient conserved domain protein 1
ancient conserved domain-containing protein 1
cyclin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373992.1 → NP_001360921.1  metal transporter CNNM1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140375
    Consensus CDS
    CCDS89394.1
    UniProtKB/TrEMBL
    A0A286YDL2
    Related
    ENSMUSP00000153472.2, ENSMUST00000223787.2
    Conserved Domains (1) summary
    COG1253
    Location:251 → 553
    TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

  2. NM_001424972.1 → NP_001411901.1  metal transporter CNNM1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC140375

  3. NM_031396.3 → NP_113573.2  metal transporter CNNM1 isoform 2

    See identical proteins and their annotated locations for NP_113573.2

    Status: VALIDATED

    Source sequence(s)
    AC140375, AF202994, EF041508
    Consensus CDS
    CCDS50442.1
    UniProtKB/Swiss-Prot
    Q0GA42, Q9JIQ6
    Related
    ENSMUSP00000131830.2, ENSMUST00000165311.3
    Conserved Domains (1) summary
    COG1253
    Location:251 → 553
    TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    43427508..43485649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527480.5 → XP_006527543.1  metal transporter CNNM1 isoform X1

    Conserved Domains (1) summary
    COG1253
    Location:251 → 553
    TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

  2. XM_006527482.5 → XP_006527545.1  metal transporter CNNM1 isoform X2

    Conserved Domains (1) summary
    COG1253
    Location:251 → 553
    TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

  3. XM_036161732.1 → XP_036017625.1  metal transporter CNNM1 isoform X3

    Conserved Domains (1) summary
    COG1253
    Location:251 → 553
    TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

RNA

  1. XR_004940187.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0GA42.5 GenPept UniProtKB/Swiss-Prot:Q0GA42

Gene LinkOut

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