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VDAC2 voltage dependent anion channel 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836886, updated on 18-Sep-2024

Summary

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Official Symbol
VDAC2
Official Full Name
voltage dependent anion channel 2
Primary source
TAIR:AT5G67500
Locus tag
AT5G67500
See related
Araport:AT5G67500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 2; ATVDAC2; K9I9.6; K9I9_6; voltage dependent anion channel 2
Summary
Encodes a voltage-dependent anion channel (VDAC: AT3G01280/VDAC1, AT5G67500/VDAC2, AT5G15090/VDAC3, AT5G57490/VDAC4, AT5G15090/VDAC5). VDACs are reported to be porin-type, beta-barrel diffusion pores. They are prominently localized in the outer mitochondrial membrane and are involved in metabolite exchange between the organelle and the cytosol.
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Genomic context

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See VDAC2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
8
Sequence:
Chromosome: 5; NC_003076.8 (26935075..26937650)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene formin homolog 6 Neighboring gene BTB and TAZ domain protein 4 Neighboring gene ncRNA Neighboring gene succinate dehydrogenase assembly factor Neighboring gene Translation protein SH3-like family protein Neighboring gene adenosine-5'-phosphosulfate (APS) kinase 4 Neighboring gene plant U-box 49 Neighboring gene Arabinanase/levansucrase/invertase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Voltage-dependent-anion-channels (VDACs) in Arabidopsis have a dual localization in the cell but show a distinct role in mitochondria. Robert N, et al. Plant Mol Biol, 2012 Mar. PMID 22294207
  2. Molecular and genetic characterization of the gene family encoding the voltage-dependent anion channel in Arabidopsis. Tateda C, et al. J Exp Bot, 2011 Oct. PMID 21705391, Free PMC Article
  3. Pathogen inducible voltage-dependent anion channel (AtVDAC) isoforms are localized to mitochondria membrane in Arabidopsis. Lee SM, et al. Mol Cells, 2009 Mar 31. PMID 19326079
  4. The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions. Brugière S, et al. Phytochemistry, 2004 Jun. PMID 15276431
  5. Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Elrouby N, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855607, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtVDAC2 has a main function in mitochondria
    Title: Voltage-dependent-anion-channels (VDACs) in Arabidopsis have a dual localization in the cell but show a distinct role in mitochondria.
  2. VDAC2 and VDAC4 are important for leaf development, the mitochondrial membrane potential, and pollen development.
    Title: Molecular and genetic characterization of the gene family encoding the voltage-dependent anion channel in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_001345833.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables voltage-gated monoatomic anion channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast envelope HDA PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in plant-type cell wall HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
voltage dependent anion channel 2
NP_001190641.1
  • voltage dependent anion channel 2 (VDAC2); CONTAINS InterPro DOMAIN/s: Porin, eukaryotic type (InterPro:IPR001925); BEST Arabidopsis thaliana protein match is: voltage dependent anion channel 5 (TAIR:AT3G49920.1).
NP_001318898.1
  • voltage dependent anion channel 2 (VDAC2); FUNCTIONS IN: voltage-gated anion channel activity; INVOLVED IN: response to bacterium, anion transport; LOCATED IN: in 7 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Porin, eukaryotic type (InterPro:IPR001925); BEST Arabidopsis thaliana protein match is: voltage dependent anion channel 5 (TAIR:AT3G49920.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    26935075..26937650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126150.5 → NP_201551.1  voltage dependent anion channel 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_201551.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FJX3
    UniProtKB/TrEMBL
    A0A178UUR9, A0A5S9YIL5, A0A654GFB8
    Conserved Domains (1) summary
    cd07306
    Location:5 → 275
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  2. NM_001203712.1 → NP_001190641.1  voltage dependent anion channel 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190641.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UUR9, F4K3R8
    Conserved Domains (1) summary
    cd07306
    Location:5 → 302
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  3. NM_001345833.1 → NP_001318898.1  voltage dependent anion channel 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2H1ZE94, A0A7G2FKP9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FJX3.1

Gene LinkOut

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