RPS6KL1 ribosomal protein S6 kinase like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPS6KL1provided by HGNC
Official Full Name: ribosomal protein S6 kinase like 1provided by HGNC
Primary source: HGNC:HGNC:20222
See related: Ensembl:ENSG00000198208 AllianceGenome:HGNC:20222
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RSKL2
Summary: Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Predicted to be located in ribosome. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in brain (RPKM 4.6), testis (RPKM 3.0) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q24.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (74903951..74923260, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (69113051..69132361, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (75370654..75389963, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identified as a pseudokinase and named RSKL2.
Title: The protein kinase complement of the human genome.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

HSC2LA072 (e-PCR)
- UniSTS:25660

D1S1425 (e-PCR)
- UniSTS:149621

G35510 (e-PCR)
- UniSTS:44150

D14S1361 (e-PCR)
- UniSTS:473800

RH78538 (e-PCR)
- UniSTS:68563

D14S1385 (e-PCR)
- UniSTS:473812

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal protein S6 kinase-like 1

NP_001357181.1

EC 2.7.11.1

NP_001357182.1

EC 2.7.11.1

NP_001357184.1

EC 2.7.11.1

NP_001357185.1

EC 2.7.11.1

NP_001357186.1

EC 2.7.11.1

NP_001357187.1

EC 2.7.11.1

NP_113652.2

EC 2.7.11.1

XP_011535508.1

EC 2.7.11.1

XP_011535509.1

EC 2.7.11.1

XP_011535513.1

EC 2.7.11.1

XP_011535515.1

EC 2.7.11.1

XP_016877169.1

EC 2.7.11.1

XP_016877171.1

EC 2.7.11.1

XP_016877172.1

EC 2.7.11.1

XP_016877173.1

EC 2.7.11.1

XP_016877174.1

EC 2.7.11.1

XP_016877175.1

EC 2.7.11.1

XP_016877177.1

EC 2.7.11.1

XP_016877180.1

EC 2.7.11.1

XP_024305484.1

EC 2.7.11.1

XP_024305485.1

EC 2.7.11.1

XP_047287752.1

EC 2.7.11.1

XP_047287753.1

EC 2.7.11.1

XP_047287754.1

EC 2.7.11.1

XP_047287755.1

EC 2.7.11.1

XP_047287756.1

EC 2.7.11.1

XP_047287757.1

EC 2.7.11.1

XP_054232751.1

EC 2.7.11.1

XP_054232752.1

EC 2.7.11.1

XP_054232753.1

EC 2.7.11.1

XP_054232754.1

EC 2.7.11.1

XP_054232755.1

EC 2.7.11.1

XP_054232756.1

EC 2.7.11.1

XP_054232757.1

EC 2.7.11.1

XP_054232758.1

EC 2.7.11.1

XP_054232759.1

EC 2.7.11.1

XP_054232760.1

EC 2.7.11.1

XP_054232761.1

EC 2.7.11.1

XP_054232762.1

EC 2.7.11.1

XP_054232763.1

EC 2.7.11.1

XP_054232764.1

EC 2.7.11.1

XP_054232765.1

EC 2.7.11.1

XP_054232766.1

EC 2.7.11.1

XP_054232767.1

EC 2.7.11.1

XP_054232768.1

EC 2.7.11.1

XP_054232769.1

EC 2.7.11.1

XP_054232770.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_034007.1 RefSeqGene

Range

4183..23492

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001370252.1 → NP_001357181.1 ribosomal protein S6 kinase-like 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC006530

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:148 → 508

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
NM_001370253.1 → NP_001357182.1 ribosomal protein S6 kinase-like 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC006530

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:146 → 499

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
NM_001370255.1 → NP_001357184.1 ribosomal protein S6 kinase-like 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC006530

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cl21453
Location:148 → 305

PKc_like; Protein Kinases, catalytic domain
NM_001370256.1 → NP_001357185.1 ribosomal protein S6 kinase-like 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC006530

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cl21453
Location:148 → 307

PKc_like; Protein Kinases, catalytic domain
NM_001370257.1 → NP_001357186.1 ribosomal protein S6 kinase-like 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC006530

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cl21453
Location:131 → 249

PKc_like; Protein Kinases, catalytic domain
NM_001370258.1 → NP_001357187.1 ribosomal protein S6 kinase-like 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC006530

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cl21453
Location:131 → 219

PKc_like; Protein Kinases, catalytic domain
NM_031464.5 → NP_113652.2 ribosomal protein S6 kinase-like 1 isoform 2

See identical proteins and their annotated locations for NP_113652.2

Status: VALIDATED

Source sequence(s)

AC006530, AK299846

Consensus CDS

CCDS9834.2

UniProtKB/Swiss-Prot

A6NGM9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9, Q9Y6S9

UniProtKB/TrEMBL

B4DSP6

Related

ENSP00000450567.1, ENST00000557413.6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:148 → 539

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

RNA

NR_163404.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC006530
NR_163405.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC006530
NR_163406.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC006530

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

74903951..74923260 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047431797.1 → XP_047287753.1 ribosomal protein S6 kinase-like 1 isoform X6
XM_017021682.2 → XP_016877171.1 ribosomal protein S6 kinase-like 1 isoform X2

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:148 → 539

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
XM_047431796.1 → XP_047287752.1 ribosomal protein S6 kinase-like 1 isoform X2
XM_024449717.2 → XP_024305485.1 ribosomal protein S6 kinase-like 1 isoform X2

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:148 → 539

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
XM_011537206.4 → XP_011535508.1 ribosomal protein S6 kinase-like 1 isoform X1

See identical proteins and their annotated locations for XP_011535508.1

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:148 → 555

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
XM_011537213.4 → XP_011535515.1 ribosomal protein S6 kinase-like 1 isoform X7

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:131 → 492

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
XM_017021691.3 → XP_016877180.1 ribosomal protein S6 kinase-like 1 isoform X14
XM_047431800.1 → XP_047287756.1 ribosomal protein S6 kinase-like 1 isoform X12
XM_011537211.4 → XP_011535513.1 ribosomal protein S6 kinase-like 1 isoform X6

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:131 → 508

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
XM_047431801.1 → XP_047287757.1 ribosomal protein S6 kinase-like 1 isoform X13
XM_024449716.2 → XP_024305484.1 ribosomal protein S6 kinase-like 1 isoform X2

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:148 → 539

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
XM_017021688.3 → XP_016877177.1 ribosomal protein S6 kinase-like 1 isoform X11

Conserved Domains (3) summary

smart00220
Location:177 → 353

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cl21453
Location:148 → 353

PKc_like; Protein Kinases, catalytic domain
XM_017021683.3 → XP_016877172.1 ribosomal protein S6 kinase-like 1 isoform X3

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cl21453
Location:148 → 525

PKc_like; Protein Kinases, catalytic domain
XM_017021684.3 → XP_016877173.1 ribosomal protein S6 kinase-like 1 isoform X4

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:148 → 523

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
XM_017021680.3 → XP_016877169.1 ribosomal protein S6 kinase-like 1 isoform X1

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:148 → 555

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
XM_011537207.3 → XP_011535509.1 ribosomal protein S6 kinase-like 1 isoform X1

See identical proteins and their annotated locations for XP_011535509.1

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:148 → 555

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
XM_047431799.1 → XP_047287755.1 ribosomal protein S6 kinase-like 1 isoform X9

Related

ENSP00000450660.1, ENST00000555009.5
XM_047431798.1 → XP_047287754.1 ribosomal protein S6 kinase-like 1 isoform X8
XM_017021685.3 → XP_016877174.1 ribosomal protein S6 kinase-like 1 isoform X5

UniProtKB/TrEMBL

B4DSP6

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:148 → 555

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
XM_017021686.3 → XP_016877175.1 ribosomal protein S6 kinase-like 1 isoform X10

Conserved Domains (2) summary

cd02677
Location:48 → 122

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cl21453
Location:148 → 439

PKc_like; Protein Kinases, catalytic domain