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TRPT1 tRNA phosphotransferase 1 [ Homo sapiens (human) ]

Gene ID: 83707, updated on 14-Nov-2024

Summary

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Official Symbol
TRPT1provided by HGNC
Official Full Name
tRNA phosphotransferase 1provided by HGNC
Primary source
HGNC:HGNC:20316
See related
Ensembl:ENSG00000149743 MIM:610470; AllianceGenome:HGNC:20316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable tRNA 2'-phosphotransferase activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to act upstream of or within regulation of protein kinase activity. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart (RPKM 18.8), duodenum (RPKM 15.3) and 25 other tissues See more
Orthologs
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Genomic context

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See TRPT1 in Genome Data Viewer
Location:
11q13.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64223799..64226257, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64213745..64216203, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63991271..63993658, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3460 Neighboring gene uncharacterized LOC105369339 Neighboring gene MPRA-validated peak1294 silencer Neighboring gene uncharacterized LOC124902686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63948751-63949252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63949253-63949752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63951637-63952142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3462 Neighboring gene stress induced phosphoprotein 1 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:63972802-63973364 and GRCh37_chr11:63973365-63973927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4888 Neighboring gene FERM domain containing kindlin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63992564-63993286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63993887-63994406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63994407-63994924 Neighboring gene uncharacterized LOC124902687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3465 Neighboring gene nudix hydrolase 22 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3466 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs. Weixler L, et al. Nucleic Acids Res, 2022 Sep 9. PMID 36018800, Free PMC Article
  2. A human homolog of the yeast gene encoding tRNA 2'-phosphotransferase: cloning, characterization and complementation analysis. Hu QD, et al. Cell Mol Life Sci, 2003 Aug. PMID 14504659, Free PMC Article
  3. Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation. Yang X, et al. Nucleic Acids Res, 2023 Aug 11. PMID 37334830, Free PMC Article
  4. Genome-wide association study of the child behavior checklist dysregulation profile. Mick E, et al. J Am Acad Child Adolesc Psychiatry, 2011 Aug. PMID 21784300, Free PMC Article
  5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.
    Title: Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.
  2. ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs.
    Title: ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of the child behavior checklist dysregulation profile.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of tRNA phosphotransferase 1 (TRPT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11134

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA 2'-phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in tRNA splicing, via endonucleolytic cleavage and ligation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA 2'-phosphotransferase 1
Names
tRNA splicing 2' phosphotransferase 1
NP_001028850.2
NP_001153861.1
NP_001153862.1
NP_001153864.1
NP_001153865.1
NP_001317227.1
NP_113660.1
XP_005274402.1
XP_005274403.1
XP_005274404.1
XP_006718770.1
XP_016873889.1
XP_024304476.1
XP_024304477.1
XP_047283635.1
XP_047283636.1
XP_047283637.1
XP_047283638.1
XP_054226108.1
XP_054226109.1
XP_054226110.1
XP_054226111.1
XP_054226112.1
XP_054226113.1
XP_054226114.1
XP_054226115.1
XP_054226116.1
XP_054226117.1
XP_054226118.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033678.4 → NP_001028850.2  tRNA 2'-phosphotransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001028850.2

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS31595.1
    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
    Related
    ENSP00000314073.6, ENST00000317459.11
    Conserved Domains (1) summary
    pfam01885
    Location:26 → 203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  2. NM_001160389.2 → NP_001153861.1  tRNA 2'-phosphotransferase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS53652.1
    UniProtKB/Swiss-Prot
    Q86TN4
    Related
    ENSP00000378050.2, ENST00000394546.6
    Conserved Domains (1) summary
    pfam01885
    Location:31 → 204
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  3. NM_001160390.2 → NP_001153862.1  tRNA 2'-phosphotransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001153862.1

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS31595.1
    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
    Conserved Domains (1) summary
    pfam01885
    Location:26 → 203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  4. NM_001160392.2 → NP_001153864.1  tRNA 2'-phosphotransferase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS53653.1
    UniProtKB/TrEMBL
    F5H8A0
    Related
    ENSP00000438683.1, ENST00000541278.5
    Conserved Domains (1) summary
    pfam01885
    Location:31 → 186
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  5. NM_001160393.1 → NP_001153865.1  tRNA 2'-phosphotransferase 1 isoform 5

    See identical proteins and their annotated locations for NP_001153865.1

    Status: VALIDATED

    Source sequence(s)
    AY211494, BC005133, BM982538
    UniProtKB/Swiss-Prot
    Q86TN4
    Conserved Domains (1) summary
    pfam01885
    Location:31 → 203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  6. NM_001330298.2 → NP_001317227.1  tRNA 2'-phosphotransferase 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS81579.1
    UniProtKB/TrEMBL
    F5H6B6
    Related
    ENSP00000437741.1, ENST00000546089.5

  7. NM_031472.4 → NP_113660.1  tRNA 2'-phosphotransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_113660.1

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS44639.1
    Related
    ENSP00000378051.3, ENST00000394547.7
    Conserved Domains (1) summary
    pfam01885
    Location:1 → 154
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64223799..64226257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448709.2 → XP_024304477.1  tRNA 2'-phosphotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
    Conserved Domains (1) summary
    pfam01885
    Location:26 → 203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  2. XM_047427679.1 → XP_047283635.1  tRNA 2'-phosphotransferase 1 isoform X3

  3. XM_006718707.4 → XP_006718770.1  tRNA 2'-phosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006718770.1

    Conserved Domains (1) summary
    pfam01885
    Location:31 → 203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  4. XM_024448708.2 → XP_024304476.1  tRNA 2'-phosphotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
    Conserved Domains (1) summary
    pfam01885
    Location:26 → 203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  5. XM_005274346.5 → XP_005274403.1  tRNA 2'-phosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005274403.1

    Conserved Domains (1) summary
    pfam01885
    Location:31 → 203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  6. XM_047427682.1 → XP_047283638.1  tRNA 2'-phosphotransferase 1 isoform X6

    Related
    ENSP00000439586.1, ENST00000546133.5

  7. XM_047427681.1 → XP_047283637.1  tRNA 2'-phosphotransferase 1 isoform X5

  8. XM_017018400.2 → XP_016873889.1  tRNA 2'-phosphotransferase 1 isoform X4

    Conserved Domains (1) summary
    pfam01885
    Location:1 → 154
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  9. XM_047427680.1 → XP_047283636.1  tRNA 2'-phosphotransferase 1 isoform X3

  10. XM_005274347.5 → XP_005274404.1  tRNA 2'-phosphotransferase 1 isoform X4

    Conserved Domains (1) summary
    pfam01885
    Location:1 → 154
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  11. XM_005274345.5 → XP_005274402.1  tRNA 2'-phosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005274402.1

    Conserved Domains (1) summary
    pfam01885
    Location:31 → 203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64213745..64216203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370136.1 → XP_054226111.1  tRNA 2'-phosphotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9

  2. XM_054370137.1 → XP_054226112.1  tRNA 2'-phosphotransferase 1 isoform X3

  3. XM_054370135.1 → XP_054226110.1  tRNA 2'-phosphotransferase 1 isoform X1

  4. XM_054370143.1 → XP_054226118.1  tRNA 2'-phosphotransferase 1 isoform X6

  5. XM_054370142.1 → XP_054226117.1  tRNA 2'-phosphotransferase 1 isoform X5

  6. XM_054370141.1 → XP_054226116.1  tRNA 2'-phosphotransferase 1 isoform X4

  7. XM_054370139.1 → XP_054226114.1  tRNA 2'-phosphotransferase 1 isoform X3

  8. XM_054370140.1 → XP_054226115.1  tRNA 2'-phosphotransferase 1 isoform X4

  9. XM_054370138.1 → XP_054226113.1  tRNA 2'-phosphotransferase 1 isoform X1

  10. XM_054370134.1 → XP_054226109.1  tRNA 2'-phosphotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9

  11. XM_054370133.1 → XP_054226108.1  tRNA 2'-phosphotransferase 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86TN4.2 GenPept UniProtKB/Swiss-Prot:Q86TN4

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