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Fat1 FAT atypical cadherin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83720, updated on 2-Nov-2024

Summary

Official Symbol
Fat1provided by RGD
Official Full Name
FAT atypical cadherin 1provided by RGD
Primary source
RGD:621254
See related
EnsemblRapid:ENSRNOG00000030954 AllianceGenome:RGD:621254
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fat; Fath
Summary
Predicted to enable calcium ion binding activity. Involved in cellular response to angiotensin and positive regulation of vascular associated smooth muscle cell migration. Located in cytosol and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer; esophagus squamous cell carcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and oral squamous cell carcinoma. Orthologous to human FAT1 (FAT atypical cadherin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 354.6), Lung (RPKM 285.6) and 9 other tissues See more
Orthologs
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Genomic context

See Fat1 in Genome Data Viewer
Location:
16q11
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (53909759..54029175, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (47177253..47296261, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (50372150..50501716, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene melatonin receptor 1A Neighboring gene aldolase, fructose-bisphosphate A, pseudogene 1 Neighboring gene uncharacterized LOC108348398

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protocadherin Fat 1
Names
FAT tumor suppressor homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031819.2NP_114007.1  protocadherin Fat 1 precursor

    See identical proteins and their annotated locations for NP_114007.1

    Status: PROVISIONAL

    Source sequence(s)
    AF100960
    UniProtKB/TrEMBL
    A6JPS5, G3V9W9, Q9WU10
    Related
    ENSRNOP00000073466.1, ENSRNOT00000081023.3
    Conserved Domains (5) summary
    cd11304
    Location:33403437
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00282
    Location:38553986
    LamG; Laminin G domain
    cd00054
    Location:41284164
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:40944124
    EGF; EGF-like domain
    cl09101
    Location:278357
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    53909759..54029175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275780.1XP_063131850.1  protocadherin Fat 1 isoform X3

  2. XM_063275784.1XP_063131854.1  protocadherin Fat 1 isoform X7

  3. XM_039094866.2XP_038950794.1  protocadherin Fat 1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K5L1
    Conserved Domains (4) summary
    cd11304
    Location:33633460
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00282
    Location:38784009
    LamG; Laminin G domain
    cd00054
    Location:41144150
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl29226
    Location:278357
    Cadherin; Cadherin domain
  4. XM_063275783.1XP_063131853.1  protocadherin Fat 1 isoform X5

  5. XM_017600262.3XP_017455751.1  protocadherin Fat 1 isoform X4

    UniProtKB/TrEMBL
    A6JPS5, G3V9W9
    Related
    ENSRNOP00000061869.2, ENSRNOT00000067486.3
  6. XM_017600259.3XP_017455748.1  protocadherin Fat 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K5L1
    Conserved Domains (5) summary
    cd11304
    Location:33633460
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00282
    Location:38784009
    LamG; Laminin G domain
    cd00054
    Location:41514187
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:41174147
    EGF; EGF-like domain
    cl29226
    Location:278357
    Cadherin; Cadherin domain
  7. XM_063275777.1XP_063131847.1  protocadherin Fat 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEP7
    Related
    ENSRNOP00000096269.2, ENSRNOT00000112869.2
  8. XM_063275778.1XP_063131848.1  protocadherin Fat 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEP7
  9. XM_063275781.1XP_063131851.1  protocadherin Fat 1 isoform X3

  10. XM_063275782.1XP_063131852.1  protocadherin Fat 1 isoform X3

  11. XM_063275779.1XP_063131849.1  protocadherin Fat 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEP7
  12. XM_063275785.1XP_063131855.1  protocadherin Fat 1 isoform X8

    Related
    ENSRNOP00000111050.1, ENSRNOT00000159710.1

RNA

  1. XR_005494675.2 RNA Sequence