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BIP3 Heat shock protein 70 (Hsp 70) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837429, updated on 18-Sep-2024

Summary

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Official Symbol
BIP3
Official Full Name
Heat shock protein 70 (Hsp 70) family protein
Primary source
TAIR:AT1G09080
Locus tag
AT1G09080
See related
Araport:AT1G09080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
binding protein 3; F7G19.5; F7G19_5
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Genomic context

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See BIP3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Sequence:
Chromosome: 1; NC_003070.9 (2929217..2931850, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene arginine-glutamic acid dipeptide repeat protein Neighboring gene JmjC domain protein JMJ24 Neighboring gene soybean gene regulated by cold-2 Neighboring gene respiratory burst oxidase-like protein Neighboring gene 26S proteasome AAA-ATPase subunit RPT5B Neighboring gene tRNA-Glu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endoplasmic reticulum-mediated unfolded protein response is an integral part of singlet oxygen signalling in plants. Beaugelin I, et al. Plant J, 2020 Jun. PMID 31975462
  2. The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress. Mathur S, et al. Plant Physiol, 2011 Dec. PMID 22021418, Free PMC Article
  3. Constitutive BiP protein accumulation in Arabidopsis mutants defective in a gene encoding chloroplast-resident stearoyl-acyl carrier protein desaturase. Iwata Y, et al. Genes Cells, 2018 Jun. PMID 29688606
  4. BiP3 supports the early stages of female gametogenesis in the absence of BiP1 and BiP2 in Arabidopsis thaliana. Maruyama D, et al. Plant Signal Behav, 2015. PMID 26251880, Free PMC Article
  5. The THERMOSENSITIVE MALE STERILE 1 Interacts with the BiPs via DnaJ Domain and Stimulates Their ATPase Enzyme Activities in Arabidopsis. Ma ZX, et al. PLoS One, 2015. PMID 26186593, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study identified a mutant that shows constitutive BiP3 protein accumulation without treatment with endoplasmic reticulum (ER) stress inducers. The causal gene for constitutive BiP3 accumulation was found to be SSI2 gene; finding suggests a genetic link between fatty acid metabolism in the chloroplast and ER functions.
    Title: Constitutive BiP protein accumulation in Arabidopsis mutants defective in a gene encoding chloroplast-resident stearoyl-acyl carrier protein desaturase.
  2. BIP3 supports the early stages of female gametophyte development, but not polar nuclear fusion, in the absence of BiP1 and BiP2.
    Title: BiP3 supports the early stages of female gametogenesis in the absence of BiP1 and BiP2 in Arabidopsis thaliana.
  3. the DnaJ domain of TMS1 could interact with BiP1 and BiP3, and could stimulate their ATPase enzyme activities.
    Title: The THERMOSENSITIVE MALE STERILE 1 Interacts with the BiPs via DnaJ Domain and Stimulates Their ATPase Enzyme Activities in Arabidopsis.
  4. Results show that bZIP17 regulate the accumulation of the transcript for the chaperone BiP3 under salt stress conditions.
    Title: bZIP17 and bZIP60 Regulate the Expression of BiP3 and Other Salt Stress Responsive Genes in an UPR-Independent Manner in Arabidopsis thaliana.
  5. the bip1 bip2 bip3 triple mutation is lethal in pollen.
    Title: Multiple BiP genes of Arabidopsis thaliana are required for male gametogenesis and pollen competitiveness.
  6. Data show detectable amounts of YFP-bZIP28 escaped from endoplasmic reticulum (ER) to nuclei under unstressed conditions in the bip1/bip1 bip2/+ and in the bip1/+ bip2/bip2 and bip3 mutant lines.
    Title: BINDING PROTEIN is a master regulator of the endoplasmic reticulum stress sensor/transducer bZIP28 in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_100779.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within pollen tube growth IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within protein folding TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to singlet oxygen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 PubMed 
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory vesicle HDA PubMed 

General protein information

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Preferred Names
Heat shock protein 70 (Hsp 70) family protein
NP_001184944.1
  • BIP3; FUNCTIONS IN: ATP binding; INVOLVED IN: protein folding, response to heat, pollen tube growth; LOCATED IN: endoplasmic reticulum lumen; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock protein 70, conserved site (InterPro:IPR018181), Heat shock protein Hsp70 (InterPro:IPR001023), Heat shock protein 70 (InterPro:IPR013126); BEST Arabidopsis thaliana protein match is: Heat shock protein 70 (Hsp 70) family protein (TAIR:AT5G42020.1).
NP_172382.4
  • BIP3; FUNCTIONS IN: ATP binding; INVOLVED IN: protein folding, response to heat, pollen tube growth; LOCATED IN: endoplasmic reticulum lumen; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock protein 70, conserved site (InterPro:IPR018181), Heat shock protein Hsp70 (InterPro:IPR001023), Heat shock protein 70 (InterPro:IPR013126); BEST Arabidopsis thaliana protein match is: heat shock protein 70 (Hsp 70) family protein (TAIR:AT5G28540.1); Has 36561 Blast hits to 35981 proteins in 4871 species: Archae - 169; Bacteria - 17528; Metazoa - 4151; Fungi - 1824; Plants - 1283; Viruses - 337; Other Eukaryotes - 11269 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    2929217..2931850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198015.2 → NP_001184944.1  Heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001184944.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WHW4, A0A5S9TDP6
    Conserved Domains (1) summary
    PTZ00009
    Location:43 → 648
    PTZ00009; heat shock 70 kDa protein; Provisional

  2. NM_100779.5 → NP_172382.4  Heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172382.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4HZD5, O04022, Q8H1B3
    Conserved Domains (2) summary
    cd10241
    Location:50 → 423
    HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
    PTZ00009
    Location:53 → 658
    PTZ00009; heat shock 70 kDa protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8H1B3.1

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