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Tas1r3 taste receptor, type 1, member 3 [ Mus musculus (house mouse) ]

Gene ID: 83771, updated on 2-Nov-2024

Summary

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Official Symbol
Tas1r3provided by MGI
Official Full Name
taste receptor, type 1, member 3provided by MGI
Primary source
MGI:MGI:1933547
See related
Ensembl:ENSMUSG00000029072 AllianceGenome:MGI:1933547
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sac; T1r3
Summary
Predicted to enable G protein-coupled receptor activity and taste receptor activity. Predicted to contribute to sweet taste receptor activity. Acts upstream of or within sensory perception of sweet taste. Predicted to be located in Golgi apparatus. Predicted to be part of sweet taste receptor complex. Predicted to be active in plasma membrane. Is expressed in circumvallate papillae and tongue anterior part. Orthologous to human TAS1R3 (taste 1 receptor member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 1.6), thymus adult (RPKM 1.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tas1r3 in Genome Data Viewer
Location:
4 E2; 4 87.65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155943725..155947810, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155859268..155863353, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4740 Neighboring gene STARR-positive B cell enhancer ABC_E8042 Neighboring gene aurora kinase A interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10297 Neighboring gene matrix-remodelling associated 8 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1671 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene pseudouridylate synthase-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. T1r3 taste receptor involvement in gustatory neural responses to ethanol and oral ethanol preference. Brasser SM, et al. Physiol Genomics, 2010 May. PMID 20145204, Free PMC Article
  2. Initial licking responses of mice to sweeteners: effects of tas1r3 polymorphisms. Glendinning JI, et al. Chem Senses, 2005 Sep. PMID 16135742
  3. Expression and purification of functional ligand-binding domains of T1R3 taste receptors. Nie Y, et al. Chem Senses, 2006 Jul. PMID 16621970
  4. Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction. Martin B, et al. J Biol Chem, 2017 Jul 7. PMID 28522608, Free PMC Article
  5. Involvement of T1R3 in calcium-magnesium taste. Tordoff MG, et al. Physiol Genomics, 2008 Aug 15. PMID 18593862, Free PMC Article

See all (132) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sucralose regulates postprandial blood glucose in mice through intestinal sweet taste receptors Tas1r2/Tas1r3.
    Title: Sucralose regulates postprandial blood glucose in mice through intestinal sweet taste receptors Tas1r2/Tas1r3.
  2. Taste receptor type 1 member 3 mediates diet-induced cognitive impairment in mice.
    Title: Taste receptor type 1 member 3 mediates diet-induced cognitive impairment in mice.
  3. Taste receptor type 1 member 3 enables western diet-induced anxiety in mice.
    Title: Taste receptor type 1 member 3 enables western diet-induced anxiety in mice.
  4. Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.
    Title: Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.
  5. Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
    Title: Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
  6. Loss of the nutrient receptor Tas1R3 reduces atherosclerotic plaque accumulation and hepatic steatosis in ApoE(-/-) mice.
    Title: Loss of the nutrient receptor Tas1R3 reduces atherosclerotic plaque accumulation and hepatic steatosis in ApoE(-/-) mice.
  7. Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids.
    Title: Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids.
  8. TAS1R3 is not required to mount an immune response to the helminth Heligmosomoides polygyrus, which infects the proximal small intestine. Examination of uninfected Tas1r3(-/-) mice revealed a modest reduction in the number of tuft cells in the proximal small intestine but a severe decrease in the distal small intestine at homeostasis.
    Title: The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis.
  9. this study shows that taste receptor T1R3 promotes the tumoricidal activity of hepatic CD49a(+) CD49b(-) natural killer cells
    Title: Taste receptor T1R1/T1R3 promotes the tumoricidal activity of hepatic CD49a(+) CD49b(-) natural killer cells.
  10. residual sensitivity by the T1R1+T1R3 KO mice demonstrates that a T1R-independent mechanism can contribute to the detectability of high concentrations of this prototypical umami compound stimulus
    Title: Taste sensitivity to a mixture of monosodium glutamate and inosine 5'-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor.
Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to sweet taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sweet taste receptor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to sweet taste receptor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to taste receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables taste receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of sweet taste IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of sweet taste ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sweet taste IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sensory perception of sweet taste IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory perception of sweet taste ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of umami taste IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of umami taste IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of umami taste ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
part_of sweet taste receptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of sweet taste receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
taste receptor type 1 member 3
Names
saccharin preference protein
sweet taste receptor T1R3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031872.2 → NP_114078.1  taste receptor type 1 member 3 precursor

    See identical proteins and their annotated locations for NP_114078.1

    Status: PROVISIONAL

    Source sequence(s)
    AL670236
    Consensus CDS
    CCDS19046.1
    UniProtKB/Swiss-Prot
    A2ADA0, Q91VA4, Q923K0, Q925A4, Q925D8, Q925D9
    Related
    ENSMUSP00000030949.4, ENSMUST00000030949.4
    Conserved Domains (4) summary
    pfam00003
    Location:597 → 821
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:73 → 469
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:501 → 551
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:29 → 494
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155943725..155947810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925D8.2 GenPept UniProtKB/Swiss-Prot:Q925D8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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