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KCNK16 potassium two pore domain channel subfamily K member 16 [ Homo sapiens (human) ]

Gene ID: 83795, updated on 5-Mar-2024

Summary

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Official Symbol
KCNK16provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 16provided by HGNC
Primary source
HGNC:HGNC:14464
See related
Ensembl:ENSG00000095981 MIM:607369; AllianceGenome:HGNC:14464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TALK1; TALK-1; K2p16.1
Summary
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Expression
Biased expression in stomach (RPKM 3.5), pancreas (RPKM 1.4) and 2 other tissues See more
Orthologs
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Genomic context

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See KCNK16 in Genome Data Viewer
Location:
6p21.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (39314570..39322968, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (39139109..39147515, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (39282474..39290744, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:39170808-39172007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39176709-39177666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:39177695-39178235 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91581 Neighboring gene Sharpr-MPRA regulatory region 4644 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39197829-39198556 Neighboring gene potassium two pore domain channel subfamily K member 5 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:39231061-39231786 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:39231787-39232512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39240749-39241250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39241251-39241750 Neighboring gene NANOG hESC enhancer GRCh37_chr6:39259242-39259743 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39264681-39265194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24489 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:39271654-39271813 Neighboring gene uncharacterized LOC105375047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24491 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39307295-39307796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39311103-39311940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39312615-39313116 Neighboring gene potassium two pore domain channel subfamily K member 17 Neighboring gene uncharacterized LOC107986594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39321781-39322280 Neighboring gene ANKRD39 pseudogene 1 Neighboring gene kinesin family member 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:39384626-39385126 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:39422591-39423265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24495 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:39500871-39501060 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:39508271-39508448 Neighboring gene E2F transcription factor 4 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis. Vierra NC, et al. Diabetes, 2015 Nov. PMID 26239056, Free PMC Article
  2. TALK-1 channels control β cell endoplasmic reticulum Ca(2+) homeostasis. Vierra NC, et al. Sci Signal, 2017 Sep 19. PMID 28928238, Free PMC Article
  3. Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells. Dickerson MT, et al. PLoS One, 2017. PMID 28403169, Free PMC Article
  4. Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. Han J, et al. Am J Physiol Cell Physiol, 2003 Sep. PMID 12724142
  5. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Girard C, et al. Biochem Biophys Res Commun, 2001 Mar 23. PMID 11263999

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data establish TALK-1 channels as key regulators of beta cell ER Ca(2+) and suggest that TALK-1 may be a therapeutic target to reduce ER Ca(2+) handling defects in beta cells during the pathogenesis of diabetes.
    Title: TALK-1 channels control β cell endoplasmic reticulum Ca(2+) homeostasis.
  2. The TALK-1/iOPN complex caused Vm hyperpolarization and reduced beta-cell glucose-stimulated Ca2+ influx, which is predicted to inhibit glucose stimulated insulin secretion.
    Title: Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.
  3. These findings reveal TALK-1 channels as important modulators of second-phase insulin secretion and suggest a clinically relevant mechanism for rs1535500, which may increase type 2 diabetes risk by limiting glucose-stimulated insulin secretion.
    Title: Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.
  4. at least two functional TALK-1 variants are present and may serve as background K+ currents in certain cells of the human pancreas.
    Title: Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC133123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
potassium channel subfamily K member 16
Names
2P domain potassium channel Talk-1
TWIK-related alkaline pH-activated K(+) channel 1
pancreatic potassium channel Talk-1
potassium channel, subfamily K, member 16
potassium channel, two pore domain subfamily K, member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135105.2 → NP_001128577.1  potassium channel subfamily K member 16 isoform 1

    See identical proteins and their annotated locations for NP_001128577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as TALK-1c) encodes the longest isoform (1).
    Source sequence(s)
    AL136087, BC111860, BP387644, CA843225
    Consensus CDS
    CCDS47421.1
    UniProtKB/Swiss-Prot
    Q96T55
    Related
    ENSP00000391498.2, ENST00000425054.6
    Conserved Domains (1) summary
    pfam07885
    Location:92 → 148
    Ion_trans_2; Ion channel

  2. NM_001135106.2 → NP_001128578.1  potassium channel subfamily K member 16 isoform 3

    See identical proteins and their annotated locations for NP_001128578.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as TALK-1b) contains an alternative 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF358909, AL136087, BC111860, CA843225, EU978943
    Consensus CDS
    CCDS47422.1
    UniProtKB/Swiss-Prot
    Q96T55
    Related
    ENSP00000415375.2, ENST00000437525.3
    Conserved Domains (1) summary
    pfam07885
    Location:92 → 148
    Ion_trans_2; Ion channel

  3. NM_001135107.2 → NP_001128579.1  potassium channel subfamily K member 16 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as TALK-1d) uses a different acceptor splice site at the 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (4) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL136087, BC111860, BP387644, CA843225
    Consensus CDS
    CCDS47420.1
    UniProtKB/Swiss-Prot
    Q96T55
    Related
    ENSP00000362324.4, ENST00000373227.8
    Conserved Domains (1) summary
    pfam07885
    Location:92 → 148
    Ion_trans_2; Ion channel

  4. NM_001363784.1 → NP_001350713.1  potassium channel subfamily K member 16 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL136087
    Consensus CDS
    CCDS87391.1
    UniProtKB/TrEMBL
    D6RC57
    Related
    ENSP00000423842.1, ENST00000507712.5
    Conserved Domains (1) summary
    pfam07885
    Location:27 → 83
    Ion_trans_2; Ion channel

  5. NM_032115.4 → NP_115491.1  potassium channel subfamily K member 16 isoform 2

    See identical proteins and their annotated locations for NP_115491.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as TALK-1a) contains an additional coding exon and uses a different acceptor splice site at the 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF358909, AL136087, BC111860, BP387644, CA843225
    Consensus CDS
    CCDS4843.1
    UniProtKB/Swiss-Prot
    B5TJL9, Q2M2N9, Q5TCF3, Q6X6Z3, Q6X6Z4, Q6X6Z5, Q96T55, Q9H591
    Related
    ENSP00000362326.5, ENST00000373229.9
    Conserved Domains (1) summary
    pfam07885
    Location:92 → 148
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    39314570..39322968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011346.2 → XP_016866835.1  potassium channel subfamily K member 16 isoform X1

    UniProtKB/Swiss-Prot
    Q96T55
    Conserved Domains (1) summary
    pfam07885
    Location:92 → 148
    Ion_trans_2; Ion channel

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    39139109..39147515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356512.1 → XP_054212487.1  potassium channel subfamily K member 16 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96T55.1 GenPept UniProtKB/Swiss-Prot:Q96T55

Gene LinkOut

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