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Psmd1 proteasome 26S subunit, non-ATPase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83806, updated on 2-Nov-2024

Summary

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Official Symbol
Psmd1provided by RGD
Official Full Name
proteasome 26S subunit, non-ATPase 1provided by RGD
Primary source
RGD:621669
See related
EnsemblRapid:ENSRNOG00000017730 AllianceGenome:RGD:621669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, base subcomplex. Predicted to be active in nucleus and proteasome storage granule. Orthologous to human PSMD1 (proteasome 26S subunit, non-ATPase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 564.3), Muscle (RPKM 531.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Psmd1 in Genome Data Viewer
Location:
9q35
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (94157971..94233218)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (86709714..86785213)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (93080618..93155033)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094731 Neighboring gene similar to human chromosome 2 open reading frame 72 Neighboring gene uncharacterized LOC134480602 Neighboring gene 5-hydroxytryptamine receptor 2B Neighboring gene armadillo repeat containing 9 Neighboring gene uncharacterized LOC102548542 Neighboring gene transfer RNA proline (anticodon AGG) 49

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein aggregation and proteasome dysfunction after brain ischemia. Ge P, et al. Stroke, 2007 Dec. PMID 17975104, Free PMC Article
  2. Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors. Butts BD, et al. Mol Cell Neurosci, 2005 Oct. PMID 16112871
  3. Differentially expressed genes in hippocampal cell cultures in response to an excitotoxic insult by quinolinic acid. Seidel B, et al. Brain Res Mol Brain Res, 1998 Oct 1. PMID 9757068
  4. The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis. Yi H, et al. J Biol Chem, 2007 Nov 30. PMID 17911097
  5. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Stanhill A, et al. Mol Cell, 2006 Sep 15. PMID 16973439

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of proteasome 19 and 26 dysfunction after brain ischemia
    Title: Protein aggregation and proteasome dysfunction after brain ischemia.
  2. Proteasome inhibition exerts an acute pro-survival action by stabilizing transcription factors.
    Title: Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome accessory complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome accessory complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, base subcomplex IEA
Inferred from Electronic Annotation
more info
  
is_active_in proteasome storage granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 1
Names
26S proteasome p112 subunit
26S proteasome regulatory subunit RPN2
26S proteasome regulatory subunit S1
26S proteasome, subunit p112
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031978.2 → NP_114184.2  26S proteasome non-ATPase regulatory subunit 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    O88761
    UniProtKB/TrEMBL
    A6JWF9, G3V8B6
    Related
    ENSRNOP00000024306.4, ENSRNOT00000024306.7
    Conserved Domains (2) summary
    COG5116
    Location:2 → 934
    RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    sd00044
    Location:601 → 624
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    94157971..94233218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88761.1 GenPept UniProtKB/Swiss-Prot:O88761

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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