U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ABCG40 pleiotropic drug resistance 12 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838122, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
ABCG40
Official Full Name
pleiotropic drug resistance 12
Primary source
TAIR:AT1G15520
Locus tag
AT1G15520
See related
Araport:AT1G15520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA ATP-BINDING CASSETTE FAMILY G 40; Arabidopsis thaliana ATP-binding cassette G40; ATABCG40; ATP-BINDING CASSETTE FAMILY G40; ATP-binding cassette G40; ATPDR12; PDR12; pleiotropic drug resistance 12; PLEIOTROPIC DRUG RESISTANCE 12; T16N11.3; T16N11_3
Summary
ABC transporter family involved in ABA transport and resistance to lead. Localizes to plasma membrane. Upregulated by lead. Expressed in leaves, flowers, stomata and roots.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ABCG40 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
21
Sequence:
Chromosome: 1; NC_003070.9 (5331858..5338326, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene TLC ATP/ADP transporter Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene miscRNA Neighboring gene Concanavalin A-like lectin protein kinase family protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PDR-type ABC transporter mediates cellular uptake of the phytohormone abscisic acid. Kang J, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20133880, Free PMC Article
  2. AtPDR12 contributes to lead resistance in Arabidopsis. Lee M, et al. Plant Physiol, 2005 Jun. PMID 15923333, Free PMC Article
  3. The Arabidopsis Pleiotropic Drug Resistance Transporters PEN3 and PDR12 Mediate Camalexin Secretion for Resistance to Botrytis cinerea. He Y, et al. Plant Cell, 2019 Sep. PMID 31239392, Free PMC Article
  4. WRKY1 regulates stomatal movement in drought-stressed Arabidopsis thaliana. Qiao Z, et al. Plant Mol Biol, 2016 May. PMID 26820136
  5. Sorghum extracellular leucine-rich repeat protein SbLRR2 mediates lead tolerance in transgenic Arabidopsis. Zhu FY, et al. Plant Cell Physiol, 2013 Sep. PMID 23877877

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The pleiotropic drug resistance (PDR) transporter PENETRATION3 (PEN3)/PDR8 in Arabidopsis (Arabidopsis thaliana) has been implicated in resistance to a variety of fungal pathogens. The Arabidopsis Pleiotropic Drug Resistance Transporters PEN3 and PDR12 Mediate Camalexin Secretion for Resistance to Botrytis cinerea.
    Title: The Arabidopsis Pleiotropic Drug Resistance Transporters PEN3 and PDR12 Mediate Camalexin Secretion for Resistance to Botrytis cinerea.
  2. ABCG40 imports abscisic acid into the embryo, regulating seed germination.
    Title: Abscisic acid transporters cooperate to control seed germination.
  3. Data suggest that Sorghum SbLRR2(Sb05g018800)appears to mediate Pb(II) tolerance through the elevation of AtPDR12 expression in transgenic Arabidopsis, thus activating a glutathione-independent mechanism for detoxification.
    Title: Sorghum extracellular leucine-rich repeat protein SbLRR2 mediates lead tolerance in transgenic Arabidopsis.
  4. report the identification of the ATP-binding cassette (ABC) transporter Pleiotropic drug resistance transporter PDR12 (AtPDR12)/ABCG40 as a plasma membrane abscisic acid uptake transporter
    Title: PDR-type ABC transporter mediates cellular uptake of the phytohormone abscisic acid.
  5. The results suggest that EIN2 gene mediates Pb(II) resistance, at least in part, through two distinct mechanisms, a GSH-dependent mechanism and a GSH-independent AtPDR12-mediated mechanism.
    Title: The Arabidopsis Ethylene-Insensitive 2 gene is required for lead resistance.
  6. PDR12 is an ABC transporter that contributes to lead resistance in Arabidopsis. [AtPDR12]
    Title: AtPDR12 contributes to lead resistance in Arabidopsis.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

NM_001332173.1
NM_101421.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within abscisic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in abscisic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to oomycetes IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in import into cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intercellular transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lead ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to abscisic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to ethylene TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to jasmonic acid TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to ozone IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to salicylic acid TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in stomatal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within terpenoid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
pleiotropic drug resistance 12
NP_173005.1
  • pleiotropic drug resistance 12 (PDR12); CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), Plant PDR ABC transporter associated (InterPro:IPR013581), ABC-2 type transporter (InterPro:IPR013525); BEST Arabidopsis thaliana protein match is: pleiotropic drug resistance 11 (TAIR:AT1G66950.1); Has 377983 Blast hits to 279992 proteins in 3946 species: Archae - 7615; Bacteria - 304057; Metazoa - 8776; Fungi - 6428; Plants - 5794; Viruses - 2; Other Eukaryotes - 45311 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    5331858..5338326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101421.3 → NP_173005.1  pleiotropic drug resistance 12 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173005.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9M9E1
    UniProtKB/TrEMBL
    A0A5S9ULY7, A0A654EFA3
    Conserved Domains (1) summary
    PLN03140
    Location:10 → 1423
    PLN03140; ABC transporter G family member; Provisional

  2. NM_001332173.1 → NP_001323077.1  pleiotropic drug resistance 12 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WCE1, A0A1P8AW07
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9M9E1.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools