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UBC36 ubiquitin-conjugating enzyme 36 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838260, updated on 18-Sep-2024

Summary

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Official Symbol
UBC36
Official Full Name
ubiquitin-conjugating enzyme 36
Primary source
TAIR:AT1G16890
Locus tag
AT1G16890
See related
Araport:AT1G16890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtUBC36; F17F16.19; UBC13B; UBIQUITIN CONJUGATING ENZYME 13B; ubiquitin-conjugating enzyme 36
Summary
UBC36/UBC13B encodes a protein that may play a role in DNA damage responses and error-free post-replicative DNA repair. It can bind to the MMZ/UEV1 proteins in vitro.
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Genomic context

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See UBC36 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Sequence:
Chromosome: 1; NC_003070.9 (5776177..5778529, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Ubiquitin-specific protease family C19-related protein Neighboring gene mitochondrial 28S ribosomal protein S29-like protein Neighboring gene uridylyltransferase-like protein Neighboring gene ncRNA Neighboring gene Alg9-like mannosyltransferase family Neighboring gene Curculin-like (mannose-binding) lectin family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis UBC13 differentially regulates two programmed cell death pathways in responses to pathogen and low-temperature stress. Wang L, et al. New Phytol, 2019 Jan. PMID 30218535
  2. UBC13, an E2 enzyme for Lys63-linked ubiquitination, functions in root development by affecting auxin signaling and Aux/IAA protein stability. Wen R, et al. Plant J, 2014 Nov. PMID 25142088
  3. A lysine-63-linked ubiquitin chain-forming conjugase, UBC13, promotes the developmental responses to iron deficiency in Arabidopsis roots. Li W, et al. Plant J, 2010 Apr. PMID 20113438
  4. Arabidopsis thaliana UBC13: implication of error-free DNA damage tolerance and Lys63-linked polyubiquitylation in plants. Wen R, et al. Plant Mol Biol, 2006 May. PMID 16786304
  5. Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response. Wen R, et al. Plant Cell, 2008 Jan. PMID 18178771, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results revealed that UBC13 is a key regulator in plant response to low temperature and pathogens.
    Title: Arabidopsis UBC13 differentially regulates two programmed cell death pathways in responses to pathogen and low-temperature stress.
  2. UBC13 activity is critical for all major aspects of root development. The double mutant plants were insensitive to auxin treatments and the ubc13 mutant had a reduced auxin response.
    Title: UBC13, an E2 enzyme for Lys63-linked ubiquitination, functions in root development by affecting auxin signaling and Aux/IAA protein stability.
  3. Arabidopsis contains two highly conserved and likely duplicated UBC13 genes, AtUBC13A and AtUBC13B. Data suggests the existence of an error-free DNA damage tolerance pathway in plants. [UBC13B]
    Title: Arabidopsis thaliana UBC13: implication of error-free DNA damage tolerance and Lys63-linked polyubiquitylation in plants.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001198088.1
NM_101550.4
NM_179347.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to iron ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root epidermal cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of UBC13-MMS2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
ubiquitin-conjugating enzyme 36
NP_001185017.1
  • ubiquitin-conjugating enzyme 36 (UBC36); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 35 (TAIR:AT1G78870.2).
NP_564011.1
  • ubiquitin-conjugating enzyme 36 (UBC36); FUNCTIONS IN: ubiquitin-protein ligase activity, protein binding; INVOLVED IN: root epidermal cell differentiation, response to iron ion, ubiquitin-dependent protein catabolic process; LOCATED IN: UBC13-MMS2 complex, plasma membrane; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 35 (TAIR:AT1G78870.2); Has 10361 Blast hits to 10354 proteins in 399 species: Archae - 0; Bacteria - 4; Metazoa - 4571; Fungi - 2197; Plants - 1880; Viruses - 23; Other Eukaryotes - 1686 (source: NCBI BLink).
NP_849678.1
  • ubiquitin-conjugating enzyme 36 (UBC36); FUNCTIONS IN: ubiquitin-protein ligase activity, protein binding; INVOLVED IN: root epidermal cell differentiation, response to iron ion, ubiquitin-dependent protein catabolic process; LOCATED IN: UBC13-MMS2 complex, plasma membrane; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 35 (TAIR:AT1G78870.2); Has 10019 Blast hits to 10015 proteins in 393 species: Archae - 0; Bacteria - 4; Metazoa - 4493; Fungi - 2117; Plants - 1786; Viruses - 23; Other Eukaryotes - 1596 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    5776177..5778529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198088.1 → NP_001185017.1  ubiquitin-conjugating enzyme 36 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185017.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4I615
    Conserved Domains (2) summary
    COG5078
    Location:1 → 160
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cl00154
    Location:6 → 159
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_101550.4 → NP_564011.1  ubiquitin-conjugating enzyme 36 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564011.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3EDA7, Q9FZ48
    UniProtKB/TrEMBL
    A0A5S9URX4, A0A654ECH4
    Conserved Domains (1) summary
    cl00154
    Location:6 → 150
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_179347.2 → NP_849678.1  ubiquitin-conjugating enzyme 36 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849678.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FZ48
    Conserved Domains (1) summary
    cl00154
    Location:2 → 117
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FZ48.1

Gene LinkOut

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