U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Smarcd2 SWI/SNF related BAF chromatin remodeling complex subunit D2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83833, updated on 12-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Smarcd2provided by RGD
Official Full Name
SWI/SNF related BAF chromatin remodeling complex subunit D2provided by RGD
Primary source
RGD:69289
See related
EnsemblRapid:ENSRNOG00000010557 AllianceGenome:RGD:69289
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BAF60b
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in nucleosome disassembly and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of SWI/SNF complex. Predicted to be active in nucleus. Orthologous to human SMARCD2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 439.9), Adrenal (RPKM 360.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Smarcd2 in Genome Data Viewer
Location:
10q32.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91693542..91702408, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91193752..91202817, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94451866..94460732, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene FtsJ RNA 2'-O-methyltransferase 3 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene proteasome 26S subunit, ATPase 5 Neighboring gene testicular cell adhesion molecule 1 Neighboring gene growth hormone 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Gene structure of rat BAF60b, a component of mammalian SW1/SNF complexes, and its physical linkage to the growth hormone gene and transcription factor SUG/proteasome p45 gene. Nomoto K, et al. Gene, 1997 Nov 20. PMID 9427560
  2. Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest. Iakova P, et al. Cell, 2003 May 16. PMID 12757710
  3. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. Shain AH, et al. PLoS One, 2013. PMID 23355908, Free PMC Article
  4. Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex. Otsuki T, et al. Hum Mol Genet, 2001 Nov 1. PMID 11726552
  5. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. Wang W, et al. EMBO J, 1996 Oct 1. PMID 8895581, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome disassembly IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF complex IEA
Inferred from Electronic Annotation
more info
  
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
Names
60 kDa BRG-1/Brm-associated factor subunit B
BRG1-associated factor 60B
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031983.2 → NP_114189.1  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

    See identical proteins and their annotated locations for NP_114189.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062063
    UniProtKB/Swiss-Prot
    O54771, O54772
    UniProtKB/TrEMBL
    A0A8L2Q6R2, A6HK23
    Related
    ENSRNOP00000095674.2, ENSRNOT00000108911.2
    Conserved Domains (2) summary
    TIGR01628
    Location:43 → 148
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd17675
    Location:307 → 386
    SWIB_BAF60B; SWIB domain found in BRG1-associated factor 60B (BAF60B) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    91693542..91702408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54772.3 GenPept UniProtKB/Swiss-Prot:O54772

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous