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OR3A3 olfactory receptor family 3 subfamily A member 3 [ Homo sapiens (human) ]

Gene ID: 8392, updated on 5-Mar-2024

Summary

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Official Symbol
OR3A3provided by HGNC
Official Full Name
olfactory receptor family 3 subfamily A member 3provided by HGNC
Primary source
HGNC:HGNC:8284
See related
Ensembl:ENSG00000159961 AllianceGenome:HGNC:8284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR3A6; OR3A7; OR3A8P; OR17-16; OR17-137; OR17-201
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See OR3A3 in Genome Data Viewer
Location:
17p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3411370..3424070)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3300315..3312995)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3314664..3327364)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 3 subfamily A member 2 Neighboring gene olfactory receptor family 1 subfamily R member 1 pseudogene Neighboring gene olfactory receptor family 1 subfamily E member 1 Neighboring gene olfactory receptor family 1 subfamily E member 2 Neighboring gene spermatogenesis associated 22 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:3386038-3386583 Neighboring gene aspartoacylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Population differences in the human functional olfactory repertoire. Gilad Y, et al. Mol Biol Evol, 2003 Mar. PMID 12644552
  2. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. Ben-Arie N, et al. Hum Mol Genet, 1994 Feb. PMID 8004088
  3. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. Glusman G, et al. Genomics, 2000 Jan 15. PMID 10673334
  4. Distribution of olfactory receptor genes in the human genome. Rouquier S, et al. Nat Genet, 1998 Mar. PMID 9500546
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Zody MC, et al. Nature, 2006 Apr 20. PMID 16625196, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 3A3
Names
olfactory receptor 17-201
olfactory receptor 3A6
olfactory receptor 3A7
olfactory receptor 3A8
olfactory receptor OR17-22
olfactory receptor, family 3, subfamily A, member 6
olfactory receptor, family 3, subfamily A, member 7
olfactory receptor, family 3, subfamily A, member 8 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386098.1 → NP_001373027.1  olfactory receptor 3A3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC025125
    Consensus CDS
    CCDS11025.2
    UniProtKB/Swiss-Prot
    P47888, Q2VPE4, Q6IFM6, Q9P1Q4, Q9UBE7
    UniProtKB/TrEMBL
    A0A126GWB3
    Related
    ENSP00000493211.1, ENST00000574571.4
    Conserved Domains (1) summary
    cd15233
    Location:28 → 304
    7tmA_OR3A-like; olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_012373.3 → NP_036505.3  olfactory receptor 3A3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC025125, AC087498
    Consensus CDS
    CCDS11025.2
    UniProtKB/Swiss-Prot
    P47888, Q2VPE4, Q6IFM6, Q9P1Q4, Q9UBE7
    UniProtKB/TrEMBL
    A0A126GWB3
    Related
    ENSP00000493061.1, ENST00000641141.1
    Conserved Domains (1) summary
    cd15233
    Location:28 → 304
    7tmA_OR3A-like; olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    3411370..3424070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    3300315..3312995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47888.3 GenPept UniProtKB/Swiss-Prot:P47888

Gene LinkOut

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