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Gpr137b G protein-coupled receptor 137B [ Mus musculus (house mouse) ]

Gene ID: 83924, updated on 28-Oct-2024

Summary

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Official Symbol
Gpr137bprovided by MGI
Official Full Name
G protein-coupled receptor 137Bprovided by MGI
Primary source
MGI:MGI:1891463
See related
Ensembl:ENSMUSG00000021306 AllianceGenome:MGI:1891463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tm7sf1; D13Abb1e; C730041E01
Summary
Involved in negative regulation of bone resorption; negative regulation of osteoclast differentiation; and regulation of macrophage activation. Located in lysosomal membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system. Orthologous to human GPR137B (G protein-coupled receptor 137B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in kidney adult (RPKM 66.3), lung adult (RPKM 28.3) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr137b in Genome Data Viewer
Location:
13 A1; 13 5.24 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (13528035..13568250, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (13357620..13393644, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33678 Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene ERO1-like beta pseudogene Neighboring gene STARR-seq mESC enhancer starr_33679 Neighboring gene STARR-positive B cell enhancer ABC_E7205 Neighboring gene embryonic H3 histone Neighboring gene nidogen 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages. Qu W, et al. Arterioscler Thromb Vasc Biol, 2023 Nov. PMID 37767704
  2. TM7SF1, an important autophagy regulatory protein in mouse podocytes. Hu Y, et al. Biochem Biophys Res Commun, 2020 Jul 12. PMID 32482387
  3. Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization. Islam Z, et al. Biochem Biophys Res Commun, 2019 Feb 12. PMID 30595385
  4. Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development. Spangenberg C, et al. Genomics, 1998 Mar 1. PMID 9521871
  5. Identification and characterization of a mouse homolog for decidual/trophoblast prolactin-related protein. Orwig KE, et al. Endocrinology, 1997 Dec. PMID 9389538

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages.
    Title: Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages.
  2. TM7SF1, an important autophagy regulatory protein in mouse podocytes.
    Title: TM7SF1, an important autophagy regulatory protein in mouse podocytes.
  3. A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish.
    Title: A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish.
  4. Gpr137b is involved in interleukin-4-induced M2 macrophage polarization. Gpr137b is not involved in lipopolysaccharide-induced M1 macrophage polarization.
    Title: Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein localization to lysosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
integral membrane protein GPR137B
Names
transmembrane 7 superfamily member 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031999.2 → NP_114388.2  integral membrane protein GPR137B

    See identical proteins and their annotated locations for NP_114388.2

    Status: VALIDATED

    Source sequence(s)
    AK080884, BB847916, BU758113
    Consensus CDS
    CCDS26243.1
    UniProtKB/Swiss-Prot
    Q3T9U4, Q8BNQ3, Q99LK4, Q9JHD9
    UniProtKB/TrEMBL
    A0A0R4J022
    Related
    ENSMUSP00000021738.9, ENSMUST00000021738.10
    Conserved Domains (1) summary
    TIGR03022
    Location:65 → 176
    WbaP_sugtrans; Undecaprenyl-phosphate galactose phosphotransferase, WbaP

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    13528035..13568250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516805.5 → XP_006516868.1  integral membrane protein GPR137B isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VLJ5, Q8C7F6
    Related
    ENSMUSP00000152434.2, ENSMUST00000223093.2
    Conserved Domains (1) summary
    TIGR03022
    Location:65 → 176
    WbaP_sugtrans; Undecaprenyl-phosphate galactose phosphotransferase, WbaP

RNA

  1. XR_382078.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BNQ3.2 GenPept UniProtKB/Swiss-Prot:Q8BNQ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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