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RASSF4 Ras association domain family member 4 [ Homo sapiens (human) ]

Gene ID: 83937, updated on 5-Mar-2024

Summary

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Official Symbol
RASSF4provided by HGNC
Official Full Name
Ras association domain family member 4provided by HGNC
Primary source
HGNC:HGNC:20793
See related
Ensembl:ENSG00000107551 MIM:610559; AllianceGenome:HGNC:20793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD037
Summary
The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 36.2), fat (RPKM 31.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
10q11.21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (44959802..44995891)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (45840766..45876855)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (45455250..45491339)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:45304779-45305441 Neighboring gene TMEM72 antisense RNA 1 Neighboring gene eukaryotic translation initiation factor 2A pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45324635-45325498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45348956-45349456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45374502-45375428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45403886-45404386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45404387-45404887 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:45413376-45413557 Neighboring gene transmembrane protein 72 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45427808-45428515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45428516-45429222 Neighboring gene Sharpr-MPRA regulatory region 7362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3314 Neighboring gene Sharpr-MPRA regulatory region 11970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3317 Neighboring gene Sharpr-MPRA regulatory region 2327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3318 Neighboring gene uncharacterized LOC105378281 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45467973-45468635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45468636-45469297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45470934-45471637 Neighboring gene Sharpr-MPRA regulatory region 8316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45475153-45475856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45475857-45476558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45479350-45479850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45486450-45487141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45487171-45487672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45487673-45488172 Neighboring gene uncharacterized LOC124902530 Neighboring gene DEPP autophagy regulator 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:45496487-45496987 Neighboring gene ZNF22 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45510141-45510640 Neighboring gene zinc finger protein 22 Neighboring gene double homeobox A pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RASSF4 is required for skeletal muscle differentiation. Lin YT, et al. Cell Biol Int, 2020 Feb. PMID 31508857, Free PMC Article
  2. Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression. De Smedt E, et al. Cancer Res, 2018 Mar 1. PMID 29259009
  3. RASSF4 Overexpression Inhibits the Proliferation, Invasion, EMT, and Wnt Signaling Pathway in Osteosarcoma Cells. Zhang M, et al. Oncol Res, 2017 Jan 2. PMID 28081736, Free PMC Article
  4. RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion. Han Y, et al. Tumour Biol, 2016 Apr. PMID 26526576
  5. RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family. Eckfeld K, et al. Cancer Res, 2004 Dec 1. PMID 15574778

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Wnt/beta-catenin signaling pathway participates in the effect of miR-626 on oral squamous cell carcinoma by targeting RASSF4.
    Title: Wnt/β-catenin signaling pathway participates in the effect of miR-626 on oral squamous cell carcinoma by targeting RASSF4.
  2. RASSF4 is required for skeletal muscle differentiation.
    Title: RASSF4 is required for skeletal muscle differentiation.
  3. Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression.
    Title: Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression.
  4. RASSF4 controls store operated calcium entry and endoplasmic reticulum-plasma membrane junctions through ARF6-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes.
    Title: RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P(2).
  5. RASSF4 overexpression inhibits proliferation, invasion, EMT, and Wnt signaling pathway in osteosarcoma cells.
    Title: RASSF4 Overexpression Inhibits the Proliferation, Invasion, EMT, and Wnt Signaling Pathway in Osteosarcoma Cells.
  6. the present study suggested that RASSF4 serves as an important tumor suppressor in human nonsmall cell lung cancer .
    Title: RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion.
  7. RASSF4 promotes EV71 replication and the production of viral progeny to accelerate the inhibition of the phosphorylation of AKT.
    Title: RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT.
  8. expression of SPRR1B is upregulated in oral CSCs/CICs and SPRR1B has a role in cell growth by suppression of RASSF4
    Title: Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.
  9. Single nucleotide polymorphism in RASSF4 gene is associated with acute lymphoblastic leukemia.
    Title: Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC44914

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras association domain-containing protein 4
Names
Ras association (RalGDS/AF-6) domain family 4
Ras association (RalGDS/AF-6) domain family member 4
Ras association domain family 4
tumor suppressor RASSF4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032023.4 → NP_114412.2  ras association domain-containing protein 4

    See identical proteins and their annotated locations for NP_114412.2

    Status: REVIEWED

    Source sequence(s)
    AL353801, BC032593, BI601296
    Consensus CDS
    CCDS7208.1
    UniProtKB/Swiss-Prot
    Q86WH5, Q86WH6, Q86WH7, Q8N5A9, Q8TCK6, Q9H2L5
    Related
    ENSP00000339692.4, ENST00000340258.10
    Conserved Domains (1) summary
    cl00155
    Location:175 → 261
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    44959802..44995891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    45840766..45876855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178145.1: Suppressed sequence

    Description
    NM_178145.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H2L5.2 GenPept UniProtKB/Swiss-Prot:Q9H2L5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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