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MAC3A MOS4-associated complex 3A [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839503, updated on 18-Sep-2024

Summary

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Official Symbol
MAC3A
Official Full Name
MOS4-associated complex 3A
Primary source
TAIR:AT1G04510
Locus tag
AT1G04510
See related
Araport:AT1G04510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F19P19.2; F19P19_2; MOS4-associated complex 3A; MOS4-associated complex 3A
Summary
Encodes MAC3A, a U-box proteins with homology to the yeast and human E3 ubiquitin ligase Prp19. Associated with the MOS4-Associated Complex (MAC). Involved in plant innate immunity.
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Genomic context

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See MAC3A in Genome Data Viewer
Location:
chromosome: 1
Exon count:
18
Sequence:
Chromosome: 1; NC_003070.9 (1226483..1230947)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene hypothetical protein (DUF3527) Neighboring gene CCT motif family protein Neighboring gene plasmodesmata-located protein 2 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Co-condensation with photoexcited cryptochromes facilitates MAC3A to positively control hypocotyl growth in Arabidopsis. Jiang B, et al. Sci Adv, 2023 Aug 9. PMID 37556549, Free PMC Article
  2. MAC3A and MAC3B, Two Core Subunits of the MOS4-Associated Complex, Positively Influence miRNA Biogenesis. Li S, et al. Plant Cell, 2018 Feb. PMID 29437988, Free PMC Article
  3. E3 ligases MAC3A and MAC3B ubiquitinate UBIQUITIN-SPECIFIC PROTEASE14 to regulate organ size in Arabidopsis. Guo X, et al. Plant Physiol, 2024 Jan 31. PMID 37850874, Free PMC Article
  4. A Decoy Library Uncovers U-Box E3 Ubiquitin Ligases That Regulate Flowering Time in Arabidopsis. Feke AM, et al. Genetics, 2020 Jul. PMID 32434795, Free PMC Article
  5. Two Prp19-like U-box proteins in the MOS4-associated complex play redundant roles in plant innate immunity. Monaghan J, et al. PLoS Pathog, 2009 Jul. PMID 19629177, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ligases MAC3A and MAC3B ubiquitinate UBIQUITIN-SPECIFIC PROTEASE14 to regulate organ size in Arabidopsis.
    Title: E3 ligases MAC3A and MAC3B ubiquitinate UBIQUITIN-SPECIFIC PROTEASE14 to regulate organ size in Arabidopsis.
  2. Co-condensation with photoexcited cryptochromes facilitates MAC3A to positively control hypocotyl growth in Arabidopsis.
    Title: Co-condensation with photoexcited cryptochromes facilitates MAC3A to positively control hypocotyl growth in Arabidopsis.
  3. A Decoy Library Uncovers U-Box E3 Ubiquitin Ligases That Regulate Flowering Time in Arabidopsis.
    Title: A Decoy Library Uncovers U-Box E3 Ubiquitin Ligases That Regulate Flowering Time in Arabidopsis.
  4. MAC3A and MAC3B interact with the DCL1 complex that catalyzes miRNA maturation, promote DCL1 activity, and are required for the localization of HYL1, a component of the DCL1 complex.
    Title: MAC3A and MAC3B, Two Core Subunits of the MOS4-Associated Complex, Positively Influence miRNA Biogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_001035881.1
NM_100330.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of Prp19 complex IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region HDA PubMed 
located_in nucleolus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
MOS4-associated complex 3A
NP_001030958.1
  • MOS4-associated complex 3A (MAC3A); FUNCTIONS IN: ubiquitin-protein ligase activity, nucleotide binding; INVOLVED IN: response to cadmium ion, defense response to bacterium; LOCATED IN: nucleolus, nucleus, CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), U box domain (InterPro:IPR003613), WD40 repeat (InterPro:IPR001680), Pre-mRNA-splicing factor 19 (InterPro:IPR013915), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: MOS4-associated complex 3B (TAIR:AT2G33340.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_563708.1
  • MOS4-associated complex 3A (MAC3A); FUNCTIONS IN: ubiquitin-protein ligase activity, nucleotide binding; INVOLVED IN: response to cadmium ion, defense response to bacterium; LOCATED IN: nucleolus, nucleus, CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), U box domain (InterPro:IPR003613), WD40 repeat (InterPro:IPR001680), Pre-mRNA-splicing factor 19 (InterPro:IPR013915), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: MOS4-associated complex 3B (TAIR:AT2G33340.2); Has 53700 Blast hits to 26315 proteins in 787 species: Archae - 70; Bacteria - 7824; Metazoa - 20612; Fungi - 11571; Plants - 6404; Viruses - 0; Other Eukaryotes - 7219 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    1226483..1230947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100330.3 → NP_563708.1  MOS4-associated complex 3A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563708.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P93809, Q56Y87, Q94BR4
    UniProtKB/TrEMBL
    A0A178W396, A0A5S9SJG6
    Conserved Domains (4) summary
    cd00200
    Location:224 → 508
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:225 → 262
    7WD40; WD40 repeat [structural motif]
    cd16656
    Location:3 → 54
    RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
    pfam08606
    Location:67 → 131
    Prp19; Prp19/Pso4-like

  2. NM_001035881.1 → NP_001030958.1  MOS4-associated complex 3A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030958.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W396, F4I5P3
    Conserved Domains (5) summary
    smart00504
    Location:1 → 65
    Ubox; Modified RING finger domain
    COG2319
    Location:213 → 508
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:224 → 508
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08606
    Location:67 → 130
    Prp19; Prp19/Pso4-like
    sd00039
    Location:225 → 262
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94BR4.1

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