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PFD6 prefoldin 6 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839878, updated on 18-Sep-2024

Summary

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Official Symbol
PFD6
Official Full Name
prefoldin 6
Primary source
TAIR:AT1G29990
Locus tag
AT1G29990
See related
Araport:AT1G29990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
prefoldin 6; T1P2.3; T1P2_3
Summary
Encodes a cytoplastic protein with similarity to yeast prefoldin6, a subunit of the prefoldin complex. The PFD complex is thought to function along with the TCP ring complex to properly fold microtubule proteins.
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Genomic context

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See PFD6 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (10507533..10509151)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene choice-of-anchor C domain protein, putative (Protein of unknown function, DUF642) Neighboring gene alpha-mannosidase 3 Neighboring gene Intron maturase, type II family protein Neighboring gene hypothetical protein (Protein of unknown function, DUF538)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The unconventional prefoldin RPB5 interactor mediates the gravitropic response by modulating cytoskeleton organization and auxin transport in Arabidopsis. Yang Y, et al. J Integr Plant Biol, 2022 Oct. PMID 35943836
  2. Dynamic regulation of cortical microtubule organization through prefoldin-DELLA interaction. Locascio A, et al. Curr Biol, 2013 May 6. PMID 23583555
  3. Prefoldin 6 is required for normal microtubule dynamics and organization in Arabidopsis. Gu Y, et al. Proc Natl Acad Sci U S A, 2008 Nov 18. PMID 19004800, Free PMC Article
  4. Prefoldins 3 and 5 play an essential role in Arabidopsis tolerance to salt stress. Rodríguez-Milla MA, et al. Mol Plant, 2009 May. PMID 19825635
  5. Prefoldins contribute to maintaining the levels of the spliceosome LSM2-8 complex through Hsp90 in Arabidopsis. Esteve-Bruna D, et al. Nucleic Acids Res, 2020 Jun 19. PMID 32396196, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_102739.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables Hsp90 protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to gibberellin stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cortical microtubule organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cortical microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  
part_of prefoldin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of prefoldin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
prefoldin 6
NP_174292.2
  • prefoldin 6 (PFD6); FUNCTIONS IN: unfolded protein binding; INVOLVED IN: protein folding, cortical microtubule organization; LOCATED IN: prefoldin complex, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Prefoldin beta-like (InterPro:IPR002777), Prefoldin (InterPro:IPR009053); Has 469 Blast hits to 469 proteins in 236 species: Archae - 55; Bacteria - 6; Metazoa - 162; Fungi - 121; Plants - 38; Viruses - 0; Other Eukaryotes - 87 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    10507533..10509151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_102739.4 → NP_174292.2  prefoldin 6 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174292.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2HIK4, Q8GYJ1, Q9C8S0
    UniProtKB/TrEMBL
    A0A178WBU1, A0A5S9WCS9, A0A654EE12
    Conserved Domains (1) summary
    cd00632
    Location:13 → 117
    Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2HIK4.1

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