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PDIL5-2 PDI-like 5-2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840461, updated on 18-Sep-2024

Summary

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Official Symbol
PDIL5-2
Official Full Name
PDI-like 5-2
Primary source
TAIR:AT1G35620
Locus tag
AT1G35620
See related
Araport:AT1G35620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA PROTEIN DISULFIDE ISOMERASE 8; ATPDI8; ATPDIL5-2; F15O4.20; PDI-like 5-2; PDI8; PROTEIN DISULFIDE ISOMERASE 8
Summary
Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily. Unlike several other PDI family members, transcript levels for this gene are not up-regulated in response to three different chemical inducers of ER stress (dithiothreitol, beta-mercaptoethanol, and tunicamycin). However, the level of transcripts for this gene is slightly elevated in atbzip60 mutants.
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Genomic context

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See PDIL5-2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (13156346..13158467)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene RING/U-box superfamily protein Neighboring gene Protease-associated (PA) RING/U-box zinc finger family protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis protein disulfide isomerase-8 is a type I endoplasmic reticulum transmembrane protein with thiol-disulfide oxidase activity. Yuen CY, et al. BMC Plant Biol, 2016 Aug 22. PMID 27549196, Free PMC Article
  2. Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana. Lu DP, et al. Mol Genet Genomics, 2008 Sep. PMID 18574595
  3. Arabidopsis cell wall proteome defined using multidimensional protein identification technology. Bayer EM, et al. Proteomics, 2006 Jan. PMID 16287169
  4. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
  5. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PDI8 is a type I transmembrane protein with its catalytic domain facing the lumen of the endoplasmic reticulum and functions in the oxidation of cysteines to produce disulfide bonds.
    Title: Arabidopsis protein disulfide isomerase-8 is a type I endoplasmic reticulum transmembrane protein with thiol-disulfide oxidase activity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_103262.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein disulfide isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in nucleus HDA PubMed 
located_in plant-type cell wall HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
PDI-like 5-2
NP_564462.1
  • PDI-like 5-2 (PDIL5-2); FUNCTIONS IN: protein disulfide isomerase activity; INVOLVED IN: cell redox homeostasis; LOCATED IN: endoplasmic reticulum, plasma membrane, plant-type cell wall; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336), Thioredoxin, conserved site (InterPro:IPR017937); BEST Arabidopsis thaliana protein match is: PDI-like 1-1 (TAIR:AT1G21750.2); Has 16921 Blast hits to 14897 proteins in 2775 species: Archae - 169; Bacteria - 7975; Metazoa - 3273; Fungi - 1120; Plants - 1363; Viruses - 4; Other Eukaryotes - 3017 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    13156346..13158467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_103262.5 → NP_564462.1  PDI-like 5-2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564462.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94F09, Q9LQG5
    UniProtKB/TrEMBL
    A0A178WDY8
    Conserved Domains (2) summary
    cd02961
    Location:35 → 134
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:34 → 327
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94F09.1

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