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CDPK2 calcium-dependent protein kinase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840471, updated on 18-Sep-2024

Summary

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Official Symbol
CDPK2
Official Full Name
calcium-dependent protein kinase 2
Primary source
TAIR:AT1G35670
Locus tag
AT1G35670
See related
Araport:AT1G35670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCDPK2; ATCPK11; calcium-dependent protein kinase 2; CALCIUM-DEPENDENT PROTEIN KINASE 2; CPK11; F15O4.8
Summary
Encodes a Ca(2+)-dependent, calmodulin-independent protein kinase that is rapidly induced by drought and high-salt stress but not by low-temperature stress or heat stress. Positive regulator of ABA signaling. Phosphorylates ABA responsive transcription factors ABF1 and ABF4.
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Genomic context

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See CDPK2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Sequence:
Chromosome: 1; NC_003070.9 (13205345..13208289)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene erythroid differentiation factor-like protein Neighboring gene pseudo Neighboring gene Ribosomal protein L21 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tobacco calcium-dependent protein kinases are differentially phosphorylated in vivo as part of a kinase cascade that regulates stress response. Witte CP, et al. J Biol Chem, 2010 Mar 26. PMID 20118232, Free PMC Article
  2. Two genes that encode Ca(2+)-dependent protein kinases are induced by drought and high-salt stresses in Arabidopsis thaliana. Urao T, et al. Mol Gen Genet, 1994 Aug 15. PMID 8078458
  3. Ca2+-dependent protein kinase11 and 24 modulate the activity of the inward rectifying K+ channels in Arabidopsis pollen tubes. Zhao LN, et al. Plant Cell, 2013 Feb. PMID 23449501, Free PMC Article
  4. Overexpression of the wheat salt tolerance-related gene TaSC enhances salt tolerance in Arabidopsis. Huang X, et al. J Exp Bot, 2012 Sep. PMID 22821939
  5. Abscisic acid inhibits root growth in Arabidopsis through ethylene biosynthesis. Luo X, et al. Plant J, 2014 Jul. PMID 24738778

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two abscisic acid (ABA)-activated calcium-dependent protein kinases, CPK4 and CPK11, phosphorylate the C-terminus of ACS6 and increase the stability of ACS6 in ethylene biosynthesis.
    Title: Abscisic acid inhibits root growth in Arabidopsis through ethylene biosynthesis.
  2. CPK11 and CPK24 together mediate the Ca(2+)-dependent inhibition of the inward rectifying K+ channels and participate in the regulation of pollen tube growth in Arabidopsis.
    Title: Ca2+-dependent protein kinase11 and 24 modulate the activity of the inward rectifying K+ channels in Arabidopsis pollen tubes.
  3. TaSC overexpression in Arabidopsis ecotype Columbia and AtSC knockout mutant (atsc)signi fi cantly up-regulated the expression of AtFRY1, AtSAD1, and AtCDPK2. AtCDPK2 overexpression in atsc rescued the salt-sensitive phenotype of atsc.
    Title: Overexpression of the wheat salt tolerance-related gene TaSC enhances salt tolerance in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_103271.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity HDA PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of pollen tube growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
calcium-dependent protein kinase 2
NP_174807.1
  • calcium-dependent protein kinase 2 (CDPK2); FUNCTIONS IN: calmodulin-dependent protein kinase activity, kinase activity; INVOLVED IN: response to water deprivation, response to salt stress, protein amino acid phosphorylation, positive regulation of abscisic acid mediated signaling pathway; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Serine/threonine-protein kinase domain (InterPro:IPR002290), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EF-HAND 2 (InterPro:IPR018249), Calcium-dependent protein kinase (InterPro:IPR020642), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: calcium-dependent protein kinase 4 (TAIR:AT4G09570.1); Has 134131 Blast hits to 125244 proteins in 4234 species: Archae - 175; Bacteria - 14420; Metazoa - 49980; Fungi - 18055; Plants - 27559; Viruses - 606; Other Eukaryotes - 23336 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    13205345..13208289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_103271.4 → NP_174807.1  calcium-dependent protein kinase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174807.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39016, Q949P0, Q9LQH7
    UniProtKB/TrEMBL
    A0A178W2R7
    Conserved Domains (4) summary
    PTZ00184
    Location:320 → 462
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:332 → 391
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd05117
    Location:25 → 283
    STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
    pfam00069
    Location:26 → 284
    Pkinase; Protein kinase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q39016.2

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