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TEX35 testis expressed 35 [ Homo sapiens (human) ]

Gene ID: 84066, updated on 2-Nov-2024

Summary

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Official Symbol
TEX35provided by HGNC
Official Full Name
testis expressed 35provided by HGNC
Primary source
HGNC:HGNC:25366
See related
Ensembl:ENSG00000240021 AllianceGenome:HGNC:25366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSC24; C1orf49
Summary
Located in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 26.3) See more
Orthologs
mouse all
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Genomic context

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See TEX35 in Genome Data Viewer
Location:
1q25.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (178513109..178523510)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (177867832..177878233)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (178482244..178492645)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAS protein activator like 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:178452792-178452968 Neighboring gene MPRA-validated peak476 silencer Neighboring gene uncharacterized LOC101928866 Neighboring gene negCOR silencer S4 Neighboring gene C-type lectin domain containing 20A Neighboring gene uncharacterized LOC105371631 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:178505524-178506723 Neighboring gene uncharacterized LOC124904460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1577

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and characteristics of a novel testis-specific gene, Tsc24, in human and mice. Tang A, et al. Biol Pharm Bull, 2006 Nov. PMID 17077512
  2. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. Fatima S, et al. Sci Rep, 2015 Mar 30. PMID 25820252, Free PMC Article
  3. Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening. Falconieri A, et al. Cancers (Basel), 2022 Feb 17. PMID 35205757, Free PMC Article
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
  5. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ40199, MGC26863, DKFZp564J047

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
testis-expressed protein 35
Names
Testis-Specific Conserved gene 24kDa
testis-expressed sequence 35 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170722.2 → NP_001164193.1  testis-expressed protein 35 isoform 2

    See identical proteins and their annotated locations for NP_001164193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, and differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL136694, AL513013, BC034972
    Consensus CDS
    CCDS53434.1
    UniProtKB/Swiss-Prot
    Q5T0J7
    Related
    ENSP00000356611.1, ENST00000367639.1
    Conserved Domains (1) summary
    pfam15079
    Location:1 → 204
    Tsc35; Testis-specific protein 35

  2. NM_001170723.2 → NP_001164194.1  testis-expressed protein 35 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL136694, AW340027, BE041517, BI825610
    Consensus CDS
    CCDS53433.1
    UniProtKB/Swiss-Prot
    Q5T0J7
    Related
    ENSP00000356615.3, ENST00000367643.7
    Conserved Domains (1) summary
    pfam15079
    Location:1 → 198
    Tsc35; Testis-specific protein 35

  3. NM_001170724.2 → NP_001164195.1  testis-expressed protein 35 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL136694, AL513013, BI461686
    UniProtKB/Swiss-Prot
    Q5T0J7
    Conserved Domains (1) summary
    pfam15079
    Location:1 → 196
    Tsc35; Testis-specific protein 35

  4. NM_032126.5 → NP_115502.2  testis-expressed protein 35 isoform 1

    See identical proteins and their annotated locations for NP_115502.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL136694, AL552172, AW628627
    Consensus CDS
    CCDS1323.1
    UniProtKB/Swiss-Prot
    Q5T0J7, Q5T0J8, Q5T0J9, Q8IYU6, Q8N7Z1, Q8NA15, Q9H0Q7
    Related
    ENSP00000323795.2, ENST00000319416.7
    Conserved Domains (1) summary
    pfam15079
    Location:1 → 202
    Tsc35; Testis-specific protein 35

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    178513109..178523510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    177867832..177878233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T0J7.1 GenPept UniProtKB/Swiss-Prot:Q5T0J7

Gene LinkOut

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