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FSCB fibrous sheath CABYR binding protein [ Homo sapiens (human) ]

Gene ID: 84075, updated on 7-Apr-2024

Summary

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Official Symbol
FSCBprovided by HGNC
Official Full Name
fibrous sheath CABYR binding proteinprovided by HGNC
Primary source
HGNC:HGNC:20494
See related
Ensembl:ENSG00000189139 MIM:611779; AllianceGenome:HGNC:20494
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf155
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of protein sumoylation. Predicted to be active in sperm fibrous sheath and sperm principal piece. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
14q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (44504149..44507283, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (38695562..38698696, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (44973352..44976486, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2307 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:44785502-44786701 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 2277 Neighboring gene MPRA-validated peak2143 silencer Neighboring gene Sharpr-MPRA regulatory region 10127 Neighboring gene MPRA-validated peak2144 silencer Neighboring gene uncharacterized LOC105370473 Neighboring gene uncharacterized LOC124903432

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. Li YF, et al. J Biol Chem, 2007 Nov 23. PMID 17855365
  2. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article
  3. From ORFeome to biology: a functional genomics pipeline. Wiemann S, et al. Genome Res, 2004 Oct. PMID 15489336, Free PMC Article
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Wiemann S, et al. Genome Res, 2001 Mar. PMID 11230166, Free PMC Article
  5. DNA cloning using in vitro site-specific recombination. Hartley JL, et al. Genome Res, 2000 Nov. PMID 11076863, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434F1017, DKFZp686A1639, DKFZp686J0539

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein sumoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in sperm fibrous sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fibrous sheath CABYR-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032135.4 → NP_115511.3  fibrous sheath CABYR-binding protein

    See identical proteins and their annotated locations for NP_115511.3

    Status: VALIDATED

    Source sequence(s)
    AL136775, AL356022, BC039878, DB036759
    Consensus CDS
    CCDS9679.1
    UniProtKB/Swiss-Prot
    Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3
    UniProtKB/TrEMBL
    B7Z7X6
    Related
    ENSP00000344579.4, ENST00000340446.5
    Conserved Domains (3) summary
    PRK10811
    Location:231 → 379
    rne; ribonuclease E; Reviewed
    PRK12323
    Location:304 → 504
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
    TIGR00927
    Location:443 → 588
    2A1904; K+-dependent Na+/Ca+ exchanger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    44504149..44507283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    38695562..38698696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5H9T9.3 GenPept UniProtKB/Swiss-Prot:Q5H9T9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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