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Ptov1 prostate tumor over expressed gene 1 [ Mus musculus (house mouse) ]

Gene ID: 84113, updated on 2-Nov-2024

Summary

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Official Symbol
Ptov1provided by MGI
Official Full Name
prostate tumor over expressed gene 1provided by MGI
Primary source
MGI:MGI:1933946
See related
Ensembl:ENSMUSG00000038502 AllianceGenome:MGI:1933946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcap3; 1110030G05Rik
Summary
Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of transcription regulator complex. Is expressed in several structures, including central nervous system; gonad; lung; retina nuclear layer; and skeletal muscle. Orthologous to human PTOV1 (PTOV1 extended AT-hook containing adaptor protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 123.6), adrenal adult (RPKM 93.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ptov1 in Genome Data Viewer
Location:
7 B3; 7 28.94 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44512491..44523542, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44863067..44870519, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interleukin 4 induced 1B Neighboring gene interleukin 4 induced 1 Neighboring gene TBC1 domain family, member 17 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52112565-52112765 Neighboring gene AKT1 substrate 1 Neighboring gene microRNA 707 Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene mediator complex subunit 25 Neighboring gene STARR-positive B cell enhancer ABC_E8171 Neighboring gene STARR-positive B cell enhancer ABC_E547 Neighboring gene fuzzy planar cell polarity protein Neighboring gene adaptor-related protein complex 2, alpha 1 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks. Benedit P, et al. Oncogene, 2001 Mar 22. PMID 11313889
  2. PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development. Yao YW, et al. Histochem Cell Biol, 2011 Aug. PMID 21678139
  3. Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Kambouris M, et al. Brain Res Mol Brain Res, 1994 Sep. PMID 7808216
  4. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607
  5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development
    Title: PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prostate tumor-overexpressed gene 1 protein homolog
Names
granule cell antiserum positive 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133949.2 → NP_598710.1  prostate tumor-overexpressed gene 1 protein homolog

    See identical proteins and their annotated locations for NP_598710.1

    Status: VALIDATED

    Source sequence(s)
    AC158231
    Consensus CDS
    CCDS21219.1
    UniProtKB/Swiss-Prot
    Q91VU8, Q9CTC2
    Related
    ENSMUSP00000035281.10, ENSMUST00000046575.17
    Conserved Domains (1) summary
    pfam11232
    Location:93 → 238
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44512491..44523542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153604.1 → XP_036009497.1  prostate tumor-overexpressed gene 1 protein homolog isoform X2

    Conserved Domains (1) summary
    pfam11232
    Location:93 → 234
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

  2. XM_006541323.5 → XP_006541386.1  prostate tumor-overexpressed gene 1 protein homolog isoform X2

    Conserved Domains (1) summary
    pfam11232
    Location:93 → 234
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

  3. XM_036153603.1 → XP_036009496.1  prostate tumor-overexpressed gene 1 protein homolog isoform X1

    UniProtKB/Swiss-Prot
    Q91VU8, Q9CTC2
    Conserved Domains (1) summary
    pfam11232
    Location:93 → 238
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VU8.1 GenPept UniProtKB/Swiss-Prot:Q91VU8

Gene LinkOut

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