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TRB1 telomere repeat binding factor 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841418, updated on 18-Sep-2024

Summary

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Official Symbol
TRB1
Official Full Name
telomere repeat binding factor 1
Primary source
TAIR:AT1G49950
Locus tag
AT1G49950
See related
Araport:AT1G49950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATTRB1; F2J10.16; F2J10_16; telomere repeat binding factor 1; TELOMERE REPEAT BINDING FACTOR 1
Summary
Encodes a telomeric DNA binding protein. In vitro, an N-terminal Myb domain enables it to interact with double-stranded telomeric repeats.
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Genomic context

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See TRB1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Sequence:
Chromosome: 1; NC_003070.9 (18494029..18497318, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Xanthine/uracil permease family protein Neighboring gene CLP protease proteolytic subunit 1 Neighboring gene photosystem I reaction center subunit N

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Telomere binding protein TRB1 is associated with promoters of translation machinery genes in vivo. Schrumpfová PP, et al. Plant Mol Biol, 2016 Jan. PMID 26597966
  2. Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana. Mozgová I, et al. Phytochemistry, 2008 Jun. PMID 18479720
  3. Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. Zhou Y, et al. Plant Cell, 2016 Jan. PMID 26721861, Free PMC Article
  4. AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin. Dvorácková M, et al. Plant J, 2010 Feb. PMID 19947985
  5. Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana. Schrumpfová PP, et al. FEBS Lett, 2008 Apr 30. PMID 18387366

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRB1 shows a specific genome-wide distribution pattern which suggests its role in regulation of genes involved in biogenesis of the translational machinery, in addition to its preferential telomeric localization.
    Title: Telomere binding protein TRB1 is associated with promoters of translation machinery genes in vivo.
  2. AtTRB1 is highly dynamic during interphase. The histone-like domain and the Myb domain can both direct the protein to the nucleolus.
    Title: AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin.
  3. DNA-protein interaction of the full-length and truncated variants of AtTRB1, a Single-Myb-Histone-family member with a typical structure
    Title: Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana.
  4. The domains responsible for that interaction AtTRB1 and AtPOT1b were identified.
    Title: Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_103882.4
NM_179458.3
NM_202269.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables double-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
telomere repeat binding factor 1
NP_564559.1
  • telomere repeat binding factor 1 (TRB1); FUNCTIONS IN: DNA binding, protein homodimerization activity, sequence-specific DNA binding transcription factor activity, double-stranded telomeric DNA binding; INVOLVED IN: in 8 processes; LOCATED IN: nucleus, nucleosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Histone H1/H5 (InterPro:IPR005818), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: telomere repeat binding factor 3 (TAIR:AT3G49850.1); Has 1029 Blast hits to 1009 proteins in 184 species: Archae - 7; Bacteria - 85; Metazoa - 120; Fungi - 83; Plants - 636; Viruses - 0; Other Eukaryotes - 98 (source: NCBI BLink).
NP_849789.1
  • telomere repeat binding factor 1 (TRB1); FUNCTIONS IN: DNA binding, protein homodimerization activity, sequence-specific DNA binding transcription factor activity, double-stranded telomeric DNA binding; INVOLVED IN: in 8 processes; LOCATED IN: nucleus, nucleosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Histone H1/H5 (InterPro:IPR005818), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: telomere repeat binding factor 3 (TAIR:AT3G49850.1); Has 1029 Blast hits to 1009 proteins in 184 species: Archae - 7; Bacteria - 85; Metazoa - 120; Fungi - 83; Plants - 636; Viruses - 0; Other Eukaryotes - 98 (source: NCBI BLink).
NP_973998.1
  • telomere repeat binding factor 1 (TRB1); FUNCTIONS IN: DNA binding, protein homodimerization activity, sequence-specific DNA binding transcription factor activity, double-stranded telomeric DNA binding; INVOLVED IN: in 8 processes; LOCATED IN: nucleus, nucleosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Histone H1/H5 (InterPro:IPR005818), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: telomere repeat binding factor 3 (TAIR:AT3G49850.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    18494029..18497318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_103882.4 → NP_564559.1  telomere repeat binding factor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564559.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LA70, Q8VWK4, Q8VX39, Q9LPL9
    UniProtKB/TrEMBL
    A0A178W8N7, A0A5S9WNL0
    Conserved Domains (3) summary
    smart00526
    Location:113 → 178
    H15; Domain in histone families 1 and 5
    smart00717
    Location:5 → 56
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11660
    Location:6 → 56
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

  2. NM_179458.3 → NP_849789.1  telomere repeat binding factor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849789.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LA70, Q8VWK4, Q8VX39, Q9LPL9
    UniProtKB/TrEMBL
    A0A178W8N7, A0A5S9WNL0
    Conserved Domains (3) summary
    smart00526
    Location:113 → 178
    H15; Domain in histone families 1 and 5
    smart00717
    Location:5 → 56
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11660
    Location:6 → 56
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

  3. NM_202269.2 → NP_973998.1  telomere repeat binding factor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973998.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LA70, Q8VWK4, Q8VX39, Q9LPL9
    UniProtKB/TrEMBL
    A0A178W8N7, A0A5S9WNL0
    Conserved Domains (3) summary
    smart00526
    Location:113 → 178
    H15; Domain in histone families 1 and 5
    smart00717
    Location:5 → 56
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11660
    Location:6 → 56
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VWK4.1

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