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SIRB sirohydrochlorin ferrochelatase B [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841439, updated on 18-Sep-2024

Summary

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Official Symbol
SIRB
Official Full Name
sirohydrochlorin ferrochelatase B
Primary source
TAIR:AT1G50170
Locus tag
AT1G50170
See related
Araport:AT1G50170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATSIRB; F14I3.20; F14I3_20; sirohydrochlorin ferrochelatase B
Summary
encodes sirohydrochlorin ferrochelatase catalyzing the last step of the siroheme biosynthesis
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Genomic context

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See SIRB in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Sequence:
Chromosome: 1; NC_003070.9 (18581998..18583832)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene ribonuclease H superfamily polynucleotidyl transferase Neighboring gene NB-ARC domain-containing disease resistance protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the evolutionarily conserved iron-sulfur cluster of sirohydrochlorin ferrochelatase from Arabidopsis thaliana. Saha K, et al. Biochem J, 2012 Jun 1. PMID 22414210
  2. Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S center. Raux-Deery E, et al. J Biol Chem, 2005 Feb 11. PMID 15545265
  3. Enhanced tolerance to oxidative stress in transgenic Arabidopsis plants expressing proteins of unknown function. Luhua S, et al. Plant Physiol, 2008 Sep. PMID 18614705, Free PMC Article
  4. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
  5. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In Arabidopsis thaliana the ferrochelation step is catalyzed by sirohydrochlorin ferrochelatase (SirB), which, unlike its counterparts in bacteria, contains a [4Fe-4S] type cluster which has an important physiological role in plants.
    Title: Characterization of the evolutionarily conserved iron-sulfur cluster of sirohydrochlorin ferrochelatase from Arabidopsis thaliana.
  2. the plastid-located sirohydrochlorin ferrochelatase contains a 2FE-2S center [At-SirB]
    Title: Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S center.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001333424.1
NM_001333425.1
NM_103902.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sirohydrochlorin ferrochelatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within siroheme biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in siroheme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in extracellular region ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
sirohydrochlorin ferrochelatase B
NP_564562.1
  • sirohydrochlorin ferrochelatase B (SIRB); FUNCTIONS IN: sirohydrochlorin ferrochelatase activity; INVOLVED IN: response to oxidative stress, siroheme biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12) biosynthesis CbiX (InterPro:IPR002762); Has 1927 Blast hits to 1707 proteins in 620 species: Archae - 186; Bacteria - 1447; Metazoa - 1; Fungi - 0; Plants - 45; Viruses - 0; Other Eukaryotes - 248 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    18581998..18583832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_103902.4 → NP_564562.1  sirohydrochlorin ferrochelatase B [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564562.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q84JH7, Q8L8S7, Q9SX37
    UniProtKB/TrEMBL
    A0A178WMV1, A0A5S9WNM8
    Conserved Domains (2) summary
    PLN02757
    Location:72 → 222
    PLN02757; sirohydrochlorine ferrochelatase
    COG2138
    Location:83 → 215
    SirB; Sirohydrochlorin ferrochelatase [Coenzyme transport and metabolism]

  2. NM_001333424.1 → NP_001323380.1  sirohydrochlorin ferrochelatase B [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WMV1, A0A1P8AWW0, A0A5S9WNM8

  3. NM_001333425.1 → NP_001323379.1  sirohydrochlorin ferrochelatase B [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WMV1, A0A1P8AWY5, A0A5S9WNM8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q84JH7.1

Gene LinkOut

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