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FTSH1 FTSH protease 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841447, updated on 18-Sep-2024

Summary

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Official Symbol
FTSH1
Official Full Name
FTSH protease 1
Primary source
TAIR:AT1G50250
Locus tag
AT1G50250
See related
Araport:AT1G50250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F14I3.14; F14I3_14; FTSH protease 1
Summary
encodes an FTSH protease that is localized to the chloroplast. Involved in the D1 repair cycle of Photosystem II. FtsH1 and FtsH5 are interchangeable in thylakoid membranes.
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Genomic context

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See FTSH1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (18614201..18617155, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene B3 domain protein Neighboring gene kinase family with ARM repeat domain-containing protein Neighboring gene N-terminal-transmembrane-C2 domain type 5.1 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Phototropic-responsive NPH3 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional redundancy of AtFtsH metalloproteases in thylakoid membrane complexes. Yu F, et al. Plant Physiol, 2005 Aug. PMID 16040665, Free PMC Article
  2. The FtsH protease heterocomplex in Arabidopsis: dispensability of type-B protease activity for proper chloroplast development. Zhang D, et al. Plant Cell, 2010 Nov. PMID 21062893, Free PMC Article
  3. Quality control of photosystem II: FtsH hexamers are localized near photosystem II at grana for the swift repair of damage. Yoshioka M, et al. J Biol Chem, 2010 Dec 31. PMID 20921219, Free PMC Article
  4. Mutations in the Arabidopsis VAR2 locus cause leaf variegation due to the loss of a chloroplast FtsH protease. Chen M, et al. Plant J, 2000 May. PMID 10849347
  5. The E3 ligase AtCHIP ubiquitylates FtsH1, a component of the chloroplast FtsH protease, and affects protein degradation in chloroplasts. Shen G, et al. Plant J, 2007 Oct. PMID 17714429

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results elucidate protein activity and its amount as important factors for the function of FtsH heterocomplexes that are composed of multiple isoforms in the thylakoid membrane.
    Title: The FtsH protease heterocomplex in Arabidopsis: dispensability of type-B protease activity for proper chloroplast development.
  2. part of the FtsH hexamers are juxtapositioned to PSII complexes in the grana in darkness, carrying out immediate degradation of the photodamaged D1 protein under light stress
    Title: Quality control of photosystem II: FtsH hexamers are localized near photosystem II at grana for the swift repair of damage.
  3. The interaction of CHIP with FtsH1 in vitro, in normal and in CHIP-over-expressing plants is reported.
    Title: The E3 ligase AtCHIP ubiquitylates FtsH1, a component of the chloroplast FtsH protease, and affects protein degradation in chloroplasts.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_103909.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within PSII associated light-harvesting complex II catabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within photosystem II repair TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in chloroplast thylakoid HDA PubMed 
located_in chloroplast thylakoid membrane HDA PubMed 
located_in chloroplast thylakoid membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in thylakoid lumen HDA PubMed 

General protein information

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Preferred Names
FTSH protease 1
NP_564563.1
  • FTSH protease 1 (FTSH1); FUNCTIONS IN: metallopeptidase activity, protein binding, ATP-dependent peptidase activity, ATPase activity; INVOLVED IN: photosystem II repair, PSII associated light-harvesting complex II catabolic process; LOCATED IN: thylakoid lumen, chloroplast thylakoid membrane, chloroplast, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M41, FtsH (InterPro:IPR005936), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-type, conserved site (InterPro:IPR003960), Peptidase M41 (InterPro:IPR000642); BEST Arabidopsis thaliana protein match is: FtsH extracellular protease family (TAIR:AT5G42270.1); Has 39789 Blast hits to 37355 proteins in 3308 species: Archae - 1512; Bacteria - 16133; Metazoa - 4957; Fungi - 3666; Plants - 3305; Viruses - 34; Other Eukaryotes - 10182 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    18614201..18617155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_103909.4 → NP_564563.1  FTSH protease 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564563.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04172, Q39102, Q9SX43
    UniProtKB/TrEMBL
    A0A178W3Y5, A0A5S9WNH0
    Conserved Domains (1) summary
    TIGR01241
    Location:242 → 706
    FtsH_fam; ATP-dependent metalloprotease FtsH
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q39102.2

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