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STX7 syntaxin 7 [ Homo sapiens (human) ]

Gene ID: 8417, updated on 28-Oct-2024

Summary

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Official Symbol
STX7provided by HGNC
Official Full Name
syntaxin 7provided by HGNC
Primary source
HGNC:HGNC:11442
See related
Ensembl:ENSG00000079950 MIM:603217; AllianceGenome:HGNC:11442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in lymph node (RPKM 31.8), spleen (RPKM 19.7) and 24 other tissues See more
Orthologs
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Genomic context

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See STX7 in Genome Data Viewer
Location:
6q23.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132445867..132513472, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133640859..133708445, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132767006..132834611, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 36 Neighboring gene monooxygenase DBH like 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:132675510-132676709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17549 Neighboring gene Sharpr-MPRA regulatory region 15532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25071 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:132833503-132834004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25072 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:132848222-132849421 Neighboring gene ribosomal protein L21 pseudogene 66 Neighboring gene trace amine associated receptor 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma. Strömberg S, et al. J Proteome Res, 2009 Apr. PMID 19714869
  2. Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes. Wang H, et al. Gene, 1997 Oct 15. PMID 9358037
  3. Syntaxins 13 and 7 function at distinct steps during phagocytosis. Collins RF, et al. J Immunol, 2002 Sep 15. PMID 12218144
  4. Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA. Suzuki J, et al. J Biol Chem, 2003 Jul 11. PMID 12730232
  5. Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation. Parveen S, et al. J Cell Sci, 2022 Jun 15. PMID 35762511

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Syntaxin 7 modulates seizure activity in epilepsy.
    Title: Syntaxin 7 modulates seizure activity in epilepsy.
  2. Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation.
    Title: Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation.
  3. Data suggest that accumulation of recycling T cell receptors at the immunological synapse is SNARE-dependent and that Stx7-mediated processing of recycling TCRs through endosomes is a prerequisite for the cytolytic function of cytotoxic T lymphocytes.
    Title: Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes.
  4. data reveal the presence of syntaxin 7 in the membranes of exocytosis-prone granules and phagocytosis-related granules in human neutrophils, and therefore it might play a role in both exocytosis and phagocytosis in human neutrophils
    Title: Intracellular location of syntaxin 7 in human neutrophils.
  5. The expression level of STX7 protein was inversely correlated to tumor stage, suggesting that decreased expression of STX7 is associated with more aggressive tumors.
    Title: Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma.
  6. Palmitoylation-defective syntaxin 7 is selectively retained on the plasma membrane, suggesting that palmitoylation is important for intercompartmental transport of syntaxin 7.
    Title: Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8.
  7. Results report that syntaxin 7, syntaxin 8, vti1b and VAMP8 physically and functionally interact with CFTR.
    Title: Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.
  9. syntaxin 7 has a role in the intracellular vacuolation induced by VacA
    Title: Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed
capsid gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organelle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organelle localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor localization to synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in azurophil granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane HDA PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in tertiary granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
syntaxin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050740.2 RefSeqGene

    Range
    5356..72605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001326578.2 → NP_001313507.1  syntaxin-7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL357034, AL589691
    Consensus CDS
    CCDS5153.1
    UniProtKB/Swiss-Prot
    E1P579, O15400, Q5SZW2, Q96ES9
    UniProtKB/TrEMBL
    B4DH37
    Conserved Domains (2) summary
    cd15875
    Location:168 → 227
    SNARE_syntaxin7; SNARE motif of syntaxin 7
    pfam14523
    Location:18 → 119
    Syntaxin_2; Syntaxin-like protein

  2. NM_001326579.2 → NP_001313508.1  syntaxin-7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL357034, AL589691
    Consensus CDS
    CCDS5153.1
    UniProtKB/Swiss-Prot
    E1P579, O15400, Q5SZW2, Q96ES9
    UniProtKB/TrEMBL
    B4DH37
    Conserved Domains (2) summary
    cd15875
    Location:168 → 227
    SNARE_syntaxin7; SNARE motif of syntaxin 7
    pfam14523
    Location:18 → 119
    Syntaxin_2; Syntaxin-like protein

  3. NM_001326580.2 → NP_001313509.1  syntaxin-7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL357034, AL589691
    Consensus CDS
    CCDS87441.1
    UniProtKB/Swiss-Prot
    O15400
    Related
    ENSP00000356914.4, ENST00000367937.4
    Conserved Domains (2) summary
    cd00179
    Location:9 → 148
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15875
    Location:168 → 227
    SNARE_syntaxin7; SNARE motif of syntaxin 7

  4. NM_003569.3 → NP_003560.2  syntaxin-7 isoform a

    See identical proteins and their annotated locations for NP_003560.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AJ420529, AL357034, AW500305, BC011975, BF064142, DA242979, U77942
    Consensus CDS
    CCDS5153.1
    UniProtKB/Swiss-Prot
    E1P579, O15400, Q5SZW2, Q96ES9
    UniProtKB/TrEMBL
    B4DH37
    Related
    ENSP00000356918.1, ENST00000367941.7
    Conserved Domains (2) summary
    cd15875
    Location:168 → 227
    SNARE_syntaxin7; SNARE motif of syntaxin 7
    pfam14523
    Location:18 → 119
    Syntaxin_2; Syntaxin-like protein

RNA

  1. NR_137169.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' end and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL357034, AL589691

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    132445867..132513472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    133640859..133708445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15400.4 GenPept UniProtKB/Swiss-Prot:O15400

Gene LinkOut

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