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HUB2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841968, updated on 22-Aug-2024

Summary

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Official Symbol
HUB2
Primary source
TAIR:AT1G55250
Locus tag
AT1G55250
See related
Araport:AT1G55250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F7A10.17; F7A10_17; histone mono-ubiquitination 2
Summary
Encodes one of two orthologous E3 ubiquitin ligases in Arabidopsis that are involved in monoubiquitination of histone H2B.
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Genomic context

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Location:
chromosome: 1
Exon count:
20
Sequence:
Chromosome: 1; NC_003070.9 (20606953..20612649)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene proteinase inhibitor I4, serpin (DUF716) Neighboring gene proteinase inhibitor I4, serpin (DUF716) Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene DUF538 family protein, putative (Protein of unknown function, DUF538) Neighboring gene ncRNA Neighboring gene Galactose oxidase/kelch repeat superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The chromatin-modifying protein HUB2 is involved in the regulation of lignin composition in xylem vessels. Zhang B, et al. J Exp Bot, 2020 Sep 19. PMID 32479638, Free PMC Article
  2. An Arabidopsis E3 ligase HUB2 increases histone H2B monoubiquitination and enhances drought tolerance in transgenic cotton. Chen H, et al. Plant Biotechnol J, 2019 Mar. PMID 30117653, Free PMC Article
  3. Histone H2B monoubiquitination is involved in the regulation of cutin and wax composition in Arabidopsis thaliana. Ménard R, et al. Plant Cell Physiol, 2014 Feb. PMID 24319075
  4. The Arabidopsis thaliana homolog of yeast BRE1 has a function in cell cycle regulation during early leaf and root growth. Fleury D, et al. Plant Cell, 2007 Feb. PMID 17329565, Free PMC Article
  5. Monoubiquitination of histone 2B at the disease resistance gene locus regulates its expression and impacts immune responses in Arabidopsis. Zou B, et al. Plant Physiol, 2014 May. PMID 24664204, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis.
    Title: ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis.
  2. The chromatin-modifying protein HUB2 is involved in the regulation of lignin composition in xylem vessels.
    Title: The chromatin-modifying protein HUB2 is involved in the regulation of lignin composition in xylem vessels.
  3. increases histone H2B monoubiquitination and enhances drought tolerance in transgenic cotton
    Title: An Arabidopsis E3 ligase HUB2 increases histone H2B monoubiquitination and enhances drought tolerance in transgenic cotton.
  4. Two RING E3 ligases, HISTONE MONOUBIQUITINATION 1 and 2 (HUB1 and HUB2), play a role in the selective transcriptional activation of four cuticle biosynthesis genes in Arabidopsis thaliana.
    Title: Histone H2B monoubiquitination is involved in the regulation of cutin and wax composition in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001160956.1
NM_001198304.1
NM_001198305.2
NM_104398.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone H2B deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone ubiquitin ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within innate immune response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within leaf morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within seed dormancy process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
histone mono-ubiquitination 2
NP_001154428.1
  • histone mono-ubiquitination 2; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: histone mono-ubiquitination 1 (TAIR:AT2G44950.1); Has 53227 Blast hits to 28888 proteins in 1952 species: Archae - 744; Bacteria - 5895; Metazoa - 28581; Fungi - 4356; Plants - 2855; Viruses - 120; Other Eukaryotes - 10676 (source: NCBI BLink).
NP_001185233.1
  • histone mono-ubiquitination 2 (HUB2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: histone mono-ubiquitination 1 (TAIR:AT2G44950.1).
NP_001185234.1
  • histone mono-ubiquitination 2 (HUB2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: histone mono-ubiquitination 1 (TAIR:AT2G44950.1).
NP_564680.4
  • histone mono-ubiquitination 2 (HUB2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: histone mono-ubiquitination 1 (TAIR:AT2G44950.1); Has 74071 Blast hits to 42895 proteins in 2604 species: Archae - 973; Bacteria - 11117; Metazoa - 35835; Fungi - 6236; Plants - 4620; Viruses - 230; Other Eukaryotes - 15060 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    20606953..20612649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001333696.1 → NP_001321104.1  histone mono-ubiquitination 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8APW2, A0A654EUD4, A0A7G2E4S3
    Conserved Domains (3) summary
    TIGR02168
    Location:464 → 804
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd16499
    Location:827 → 868
    RING-HC_BRE1_like; RING finger, HC subclass, found in yeast Bre1 and its homologs from eukaryotes
    pfam05557
    Location:196 → 715
    MAD; Mitotic checkpoint protein

  2. NM_001198304.1 → NP_001185233.1  histone mono-ubiquitination 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185233.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2E4S3, F4I079
    Conserved Domains (1) summary
    smart00184
    Location:833 → 885
    RING; Ring finger

  3. NM_104398.4 → NP_564680.4  histone mono-ubiquitination 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564680.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q058L1, Q8LDW7, Q9C895
    UniProtKB/TrEMBL
    A0A7G2E4S3
    Conserved Domains (1) summary
    smart00184
    Location:848 → 886
    RING; Ring finger

  4. NM_001198305.2 → NP_001185234.1  histone mono-ubiquitination 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185234.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WJX7, F4I080
    Conserved Domains (1) summary
    smart00184
    Location:331 → 383
    RING; Ring finger

  5. NM_001160956.1 → NP_001154428.1  histone mono-ubiquitination 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154428.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WHT6, A0A178WJX7
    Conserved Domains (1) summary
    smart00184
    Location:331 → 369
    RING; Ring finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C895.2

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