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GCT [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841978, updated on 22-Aug-2024

Summary

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Official Symbol
GCT
Primary source
TAIR:AT1G55325
Locus tag
AT1G55325
See related
Araport:AT1G55325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CCT; CENTER CITY; GRAND CENTRAL; MAB2; MACCHI-BOU 2
Summary
Encodes the Arabidopsis homolog of the transcriptional regulator MED13, is dynamically expressed during embryogenesis and regulates both developmental timing and the radial pattern formation.
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Genomic context

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Location:
chromosome: 1
Exon count:
26
Sequence:
Chromosome: 1; NC_003070.9 (20637333..20648434)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene SC35-like splicing factor 33 Neighboring gene acyl-activating enzyme 18 Neighboring gene uncharacterized protein Neighboring gene arabinogalactan protein 21 Neighboring gene hypothetical protein (DUF1639) Neighboring gene calpain-type cysteine protease family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss-of-function of MEDIATOR 12 or 13 subunits causes the swelling of root hairs in response to sucrose and abscisic acid in Arabidopsis. Raya-González J, et al. Plant Signal Behav, 2023 Dec 31. PMID 36942634, Free PMC Article
  2. The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis. Liu Q, et al. Nat Commun, 2020 Jun 3. PMID 32493925, Free PMC Article
  3. The MEDIATOR genes MED12 and MED13 control Arabidopsis root system configuration influencing sugar and auxin responses. Raya-González J, et al. Plant Mol Biol, 2017 Sep. PMID 28780645
  4. The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions. Gillmor CS, et al. Development, 2014 Dec. PMID 25377553, Free PMC Article
  5. The MED12-MED13 module of Mediator regulates the timing of embryo patterning in Arabidopsis. Gillmor CS, et al. Development, 2010 Jan. PMID 20023166, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss-of-function of MEDIATOR 12 or 13 subunits causes the swelling of root hairs in response to sucrose and abscisic acid in Arabidopsis.
    Title: Loss-of-function of MEDIATOR 12 or 13 subunits causes the swelling of root hairs in response to sucrose and abscisic acid in Arabidopsis.
  2. MED12/13 is required to facilitate the expression of genes making the transition from silent to active states. [MED13]
    Title: The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis.
  3. med12 and med13 single mutants exhibit shoot and root phenotypes consistent with altered auxin homeostasis including altered primary root growth, lateral root development, and root hair elongation.[MED13]
    Title: The MEDIATOR genes MED12 and MED13 control Arabidopsis root system configuration influencing sugar and auxin responses.
  4. The results suggest that HSI2 recruits MED13 and HDA6 to suppress directly a subset of seed maturation genes post-germination.
    Title: HSI2 Repressor Recruits MED13 and HDA6 to Down-Regulate Seed Maturation Gene Expression Directly During Arabidopsis Early Seedling Growth.
  5. GCT and CCT coordinate vegetative and floral transitions by repressing the repressors miR156 and FLC.
    Title: The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions.
  6. MAB2 plays a crucial role in embryo patterning and cotyledon organogenesis. [MAB2] [MACCHI-BOU 2]
    Title: MACCHI-BOU 2 is required for early embryo patterning and cotyledon organogenesis in Arabidopsis.
  7. MED13 and MED12 regulate pattern formation during Arabidopsis embryogenesis by transiently repressing a transcriptional program that interferes with this process [MED13]
    Title: The MED12-MED13 module of Mediator regulates the timing of embryo patterning in Arabidopsis.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_179478.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of development, heterochronic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of radial pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
RNA polymerase II transcription mediator
NP_001185237.1
  • GRAND CENTRAL (GCT); FUNCTIONS IN: RNA polymerase II transcription mediator activity; INVOLVED IN: regulation of development, heterochronic, regulation of radial pattern formation; LOCATED IN: mediator complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mediator complex, subunit Med13 (InterPro:IPR009401).
NP_849809.2
  • GRAND CENTRAL (GCT); INVOLVED IN: regulation of development, heterochronic, regulation of radial pattern formation; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    20637333..20648434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001333703.1 → NP_001322789.1  RNA polymerase II transcription mediator [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WE89, A0A1P8AV32

  2. NM_001333704.1 → NP_001322788.1  RNA polymerase II transcription mediator [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WE89, A0A1P8AV32

  3. NM_001198308.1 → NP_001185237.1  RNA polymerase II transcription mediator [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185237.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9WRW3
    Conserved Domains (1) summary
    pfam06333
    Location:1221 → 1585
    Med13_C; Mediator complex subunit 13 C-terminal

  4. NM_179478.2 → NP_849809.2  RNA polymerase II transcription mediator [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849809.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4I095, F4I096
    UniProtKB/TrEMBL
    A0A178WE89
    Conserved Domains (1) summary
    pfam06333
    Location:1265 → 1382
    Med13_C; Mediator complex subunit 13 C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4I096.1

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