NAS4 nicotianamine synthase 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: NAS4
Official Full Name: nicotianamine synthase 4
Primary source: TAIR:AT1G56430
Locus tag: AT1G56430
See related: Araport:AT1G56430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA NICOTIANAMINE SYNTHASE 4; ATNAS4; F13N6.10; F13N6_10; nicotianamine synthase 4
Summary: Encodes a protein with nicotianamine synthase activity.
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Genomic context

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See NAS4 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (21136835..21138277)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atnas4 plants showed enhanced sensitivity to cadmium while plants overexpressing AtNAS4 were more tolerant.. AtNAS4 displays an important role in iron distribution and proper response to iron deficiency and cadmium supply.
Title: Arabidopsis thaliana nicotianamine synthase 4 is required for proper response to iron deficiency and to cadmium exposure.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_104521.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables nicotianamine synthase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within nicotianamine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phloem transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pollen development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pollen tube growth	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: nicotianamine synthase 4

NP_176038.1

nicotianamine synthase 4 (NAS4); CONTAINS InterPro DOMAIN/s: Nicotianamine synthase (InterPro:IPR004298); BEST Arabidopsis thaliana protein match is: nicotianamine synthase 3 (TAIR:AT1G09240.1); Has 205 Blast hits to 202 proteins in 47 species: Archae - 24; Bacteria - 12; Metazoa - 0; Fungi - 20; Plants - 147; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

21136835..21138277

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104521.3 → NP_176038.1 nicotianamine synthase 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176038.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9C7X5

UniProtKB/TrEMBL

A0A178WQR7, A0A654EJ22, Q6L5P3

Conserved Domains (1) summary

PLN03075
Location:1 → 298

PLN03075; nicotianamine synthase; Provisional