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SLC37A3 solute carrier family 37 member 3 [ Homo sapiens (human) ]

Gene ID: 84255, updated on 11-Apr-2024

Summary

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Official Symbol
SLC37A3provided by HGNC
Official Full Name
solute carrier family 37 member 3provided by HGNC
Primary source
HGNC:HGNC:20651
See related
Ensembl:ENSG00000157800 MIM:619137; AllianceGenome:HGNC:20651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPX3
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in carbohydrate transport and transmembrane transport. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 19.0), thyroid (RPKM 9.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
7q34
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (140333752..140398530, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (141647320..141712712, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (140033552..140098330, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375534 Neighboring gene uncharacterized LOC124901758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26778 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:140063013-140063876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140067549-140068050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140068051-140068550 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26779 Neighboring gene RNA, 5S ribosomal pseudogene 247 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:140089807-140090308 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:140090309-140090808 Neighboring gene RNA, 5S ribosomal pseudogene 248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18711 Neighboring gene uncharacterized LOC124901759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140103431-140103932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140103933-140104432 Neighboring gene RAB19, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26781 Neighboring gene nucleoside diphosphate kinase, mitochondrial-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140143760-140144260

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The human sugar-phosphate/phosphate exchanger family SLC37. Bartoloni L, et al. Pflugers Arch, 2004 Feb. PMID 12811562
  2. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Yu Z, et al. Elife, 2018 May 10. PMID 29745899, Free PMC Article
  3. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. Pan CJ, et al. PLoS One, 2011. PMID 21949678, Free PMC Article
  4. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Palmieri M, et al. Hum Mol Genet, 2011 Oct 1. PMID 21752829
  5. Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. Wang P, et al. J Clin Invest, 2019 Jul 25. PMID 31343991, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC37A3 protein localizes in lysosomes in HeLa cells
    Title: Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16367, MGC32939

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables glucose 6-phosphate:phosphate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables xenobiotic transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in glucose-6-phosphate transport IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in phosphate ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sugar phosphate exchanger 3
Names
solute carrier family 37 (glycerol-3-phosphate transporter), member 3
sugar-phosphate exchange protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287498.2 → NP_001274427.1  sugar phosphate exchanger 3 isoform 3

    See identical proteins and their annotated locations for NP_001274427.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AK074823, BC046567, BM669953, DB481623
    Consensus CDS
    CCDS75669.1
    UniProtKB/Swiss-Prot
    Q8NCC5
    Related
    ENSP00000397481.2, ENST00000447932.6
    Conserved Domains (1) summary
    cl27298
    Location:14 → 463
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  2. NM_001363373.1 → NP_001350302.1  sugar phosphate exchanger 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC093087
    Conserved Domains (1) summary
    cl27298
    Location:14 → 410
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  3. NM_001363374.1 → NP_001350303.1  sugar phosphate exchanger 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AK074823, BC046567, BM669953, DA750092, DB481623
    Conserved Domains (1) summary
    cl27298
    Location:14 → 358
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  4. NM_001363375.1 → NP_001350304.1  sugar phosphate exchanger 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AK074823, BC046567, BM669953, CX752660, DA064851, DB481623
    Conserved Domains (1) summary
    cl27298
    Location:14 → 398
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  5. NM_001363376.1 → NP_001350305.1  sugar phosphate exchanger 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093087
    Conserved Domains (1) summary
    cl27298
    Location:14 → 391
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  6. NM_001363377.1 → NP_001350306.1  sugar phosphate exchanger 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC093087
    Conserved Domains (1) summary
    cl27298
    Location:14 → 189
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  7. NM_001363378.1 → NP_001350307.1  sugar phosphate exchanger 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AK074823, BC046567, BM669953, DA582415, DB481623
    Conserved Domains (1) summary
    cl27298
    Location:14 → 253
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  8. NM_032295.4 → NP_115671.1  sugar phosphate exchanger 3 isoform 2

    See identical proteins and their annotated locations for NP_115671.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three exons in the 3' coding region, resulting in a frameshift, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK074823, AL136583, BC028380, BM669953, DB481623
    Consensus CDS
    CCDS5858.1
    UniProtKB/Swiss-Prot
    Q8NCC5
    Related
    ENSP00000343358.3, ENST00000340308.7
    Conserved Domains (1) summary
    cd06174
    Location:84 → 341
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  9. NM_207113.3 → NP_996996.1  sugar phosphate exchanger 3 isoform 1

    See identical proteins and their annotated locations for NP_996996.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK074823, AL136583, BC028380, BM669953, DB481623
    Consensus CDS
    CCDS5859.1
    UniProtKB/Swiss-Prot
    Q6PIU7, Q86SS4, Q8NCC5, Q9BQG7
    Related
    ENSP00000321498.9, ENST00000326232.14
    Conserved Domains (1) summary
    cl27298
    Location:14 → 479
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

RNA

  1. NR_156489.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093087

  2. NR_156490.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093087

  3. NR_156491.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093087

  4. NR_156492.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093087, AK074823, AK299276, AL691676, BC046567, BM669953, CN261821, DC376346

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    140333752..140398530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420950.1 → XP_047276906.1  sugar phosphate exchanger 3 isoform X4

  2. XM_047420949.1 → XP_047276905.1  sugar phosphate exchanger 3 isoform X3

  3. XM_047420947.1 → XP_047276903.1  sugar phosphate exchanger 3 isoform X1

  4. XM_047420948.1 → XP_047276904.1  sugar phosphate exchanger 3 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    141647320..141712712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359216.1 → XP_054215191.1  sugar phosphate exchanger 3 isoform X4

  2. XM_054359215.1 → XP_054215190.1  sugar phosphate exchanger 3 isoform X3

  3. XM_054359213.1 → XP_054215188.1  sugar phosphate exchanger 3 isoform X1

  4. XM_054359214.1 → XP_054215189.1  sugar phosphate exchanger 3 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCC5.2 GenPept UniProtKB/Swiss-Prot:Q8NCC5

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