NOGC1 flavin containing monooxygenase FMO GS-OX-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: NOGC1
Official Full Name: flavin containing monooxygenase FMO GS-OX-like protein
Primary source: TAIR:AT1G62580
Locus tag: AT1G62580
See related: Araport:AT1G62580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: nitric oxide-dependent guanylate cyclase 1; T3P18.14; T3P18_14
Summary: Encodes a flavin monooxygenase that binds NO, has a higher affinity for NO than for O(2) and can generate cGMP from GTP in vitro in an NO-dependent manner.
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Genomic context

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See NOGC1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 7

Sequence:: Chromosome: 1; NC_003070.9 (23173286..23176931)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study has identified an Arabidopsis flavin monooxygenase (At1g62580) and shown that it binds NO, has a higher affinity for NO than for O(2) and that this molecule can generate cGMP from GTP in vitro in an NO-dependent manner.
Title: Identification of a novel Arabidopsis thaliana nitric oxide-binding molecule with guanylate cyclase activity in vitro.

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Pathways from PubChem

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General gene information

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NM_001334039.1

Supported by ESTs:

NM_001334040.1

Supported by ESTs:

NM_104936.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables N,N-dimethylaniline monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables nitric oxide binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within stomatal closure	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: flavin containing monooxygenase FMO GS-OX-like protein

NP_176446.1

Flavin-binding monooxygenase family protein; FUNCTIONS IN: NADP or NADPH binding, monooxygenase activity, FAD binding, flavin-containing monooxygenase activity; INVOLVED IN: oxidation reduction; LOCATED IN: intrinsic to endoplasmic reticulum membrane; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Dimethylaniline monooxygenase, N-oxide-forming (InterPro:IPR012143), Flavin-containing monooxygenase-like (InterPro:IPR020946); BEST Arabidopsis thaliana protein match is: Flavin-containing monooxygenase family protein (TAIR:AT1G63340.1); Has 12102 Blast hits to 11779 proteins in 1619 species: Archae - 69; Bacteria - 6462; Metazoa - 1123; Fungi - 1131; Plants - 751; Viruses - 0; Other Eukaryotes - 2566 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

23173286..23176931

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104936.2 → NP_176446.1 flavin containing monooxygenase FMO GS-OX-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176446.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654ELX9

Conserved Domains (1) summary

PLN02172
Location:1 → 492

PLN02172; flavin-containing monooxygenase FMO GS-OX
NM_001334039.1 → NP_001321123.1 flavin containing monooxygenase FMO GS-OX-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4HYU0, Q9SXD9

UniProtKB/TrEMBL

A0A654ELX9
NM_001334040.1 → NP_001321124.1 flavin containing monooxygenase FMO GS-OX-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8APX2