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UCH2 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842876, updated on 18-Sep-2024

Summary

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Official Symbol
UCH2
Official Full Name
Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1
Primary source
TAIR:AT1G65650
Locus tag
AT1G65650
See related
Araport:AT1G65650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F1E22.3; UBIQUITIN C-TERMINAL HYDROLASE 2
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Genomic context

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See UCH2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Sequence:
Chromosome: 1; NC_003070.9 (24415015..24417769, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene DegP protease 4 Neighboring gene miscRNA Neighboring gene Pre-mRNA splicing Prp18-interacting factor Neighboring gene cytochrome P450, family 702, subfamily A, polypeptide 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence that the Arabidopsis Ubiquitin C-terminal Hydrolases 1 and 2 associate with the 26S proteasome and the TREX-2 complex. Tian G, et al. Plant Signal Behav, 2012 Nov. PMID 22951400, Free PMC Article
  2. Ubiquitin C-terminal hydrolases 1 and 2 affect shoot architecture in Arabidopsis. Yang P, et al. Plant J, 2007 Aug. PMID 17559514
  3. COMPASS functions as a module of the INO80 chromatin remodeling complex to mediate histone H3K4 methylation in Arabidopsis. Shang JY, et al. Plant Cell, 2021 Oct 11. PMID 34270751, Free PMC Article
  4. AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. Bieluszewski T, et al. BMC Plant Biol, 2015 Mar 5. PMID 25849764, Free PMC Article
  5. Identification of proteins that interact with catalytically active calcium-dependent protein kinases from Arabidopsis. Uno Y, et al. Mol Genet Genomics, 2009 Apr. PMID 19130088

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that UCH1 and UCH2 interact with the 26S proteasome lid subunits.
    Title: Evidence that the Arabidopsis Ubiquitin C-terminal Hydrolases 1 and 2 associate with the 26S proteasome and the TREX-2 complex.
  2. substantial effect on Arabidopsis shoot development, especially with respect to inflorescence architecture
    Title: Ubiquitin C-terminal hydrolases 1 and 2 affect shoot architecture in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_105238.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within leaf development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within shoot system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within shoot system morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1
NP_564858.1
  • UCH2; CONTAINS InterPro DOMAIN/s: Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1 (InterPro:IPR001578), Ubiquitinyl hydrolase, UCH37 type (InterPro:IPR017390); BEST Arabidopsis thaliana protein match is: Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1 (TAIR:AT5G16310.1); Has 1283 Blast hits to 1275 proteins in 236 species: Archae - 0; Bacteria - 0; Metazoa - 633; Fungi - 351; Plants - 143; Viruses - 0; Other Eukaryotes - 156 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    24415015..24417769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_105238.3 → NP_564858.1  Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564858.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04482, Q945M7, Q9SHY9
    UniProtKB/TrEMBL
    A0A178WM46, A0A5S9WS88
    Conserved Domains (2) summary
    cd09617
    Location:3 → 220
    Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1
    pfam18031
    Location:269 → 314
    UCH_C; Ubiquitin carboxyl-terminal hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O04482.1

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