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Timm10b translocase of inner mitochondrial membrane 10B [ Rattus norvegicus (Norway rat) ]

Gene ID: 84384, updated on 19-Sep-2024

Summary

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Official Symbol
Timm10bprovided by RGD
Official Full Name
translocase of inner mitochondrial membrane 10Bprovided by RGD
Primary source
RGD:71097
See related
EnsemblRapid:ENSRNOG00000050846 AllianceGenome:RGD:71097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fxc1; Tim9b; tim10b
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in protein transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex and mitochondrial intermembrane space protein transporter complex. Orthologous to human TIMM10B (translocase of inner mitochondrial membrane 10B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 130.9), Adrenal (RPKM 130.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Timm10b in Genome Data Viewer
Location:
1q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (169392355..169395201)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (159980525..159983371)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170471265..170474111)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 3 Neighboring gene ADP-ribosylation factor interacting protein 2 Neighboring gene dynein heavy chain domain 1 Neighboring gene ribosomal RNA processing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of a novel cDNA expressed during the early stages of fracture healing. Hadjiargyrou M, et al. Biochem Biophys Res Commun, 1998 Aug 28. PMID 9731230
  2. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. Mühlenbein N, et al. J Biol Chem, 2004 Apr 2. PMID 14726512
  3. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480
  4. Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Vukotic M, et al. Mol Cell, 2017 Aug 3. PMID 28712724
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex ISO
Inferred from Sequence Orthology
more info
  
part_of TIM22 mitochondrial import inner membrane insertion complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial intermembrane space protein transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial intermembrane space protein transporter complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit Tim10 B
Names
fracture callus 1
fracture callus protein 1
fractured callus expressed transcript 1
mitochondrial import inner membrane translocase subunit Tim9 B
translocase of inner mitochondrial membrane 10 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389232.1 → NP_001376161.1  mitochondrial import inner membrane translocase subunit Tim10 B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    O88471, Q9R1B1
    UniProtKB/TrEMBL
    A6I7L1, F1LTU8
    Conserved Domains (1) summary
    pfam02953
    Location:3 → 64
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  2. NM_053371.3 → NP_445823.1  mitochondrial import inner membrane translocase subunit Tim10 B

    See identical proteins and their annotated locations for NP_445823.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    O88471, Q9R1B1
    UniProtKB/TrEMBL
    A6I7L1, F1LTU8
    Related
    ENSRNOP00000110273.1, ENSRNOT00000165846.1
    Conserved Domains (1) summary
    pfam02953
    Location:3 → 64
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    169392355..169395201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1B1.1 GenPept UniProtKB/Swiss-Prot:Q9R1B1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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