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Klf5 KLF transcription factor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84410, updated on 28-Oct-2024

Summary

Official Symbol
Klf5provided by RGD
Official Full Name
KLF transcription factor 5provided by RGD
Primary source
RGD:621446
See related
EnsemblRapid:ENSRNOG00000008785 AllianceGenome:RGD:621446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IKLF; Bteb2; bteb2
Summary
Enables sequence-specific DNA binding activity. Involved in cellular response to organic cyclic compound; cellular response to peptide; and positive regulation of cell population proliferation. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of transcription regulator complex. Used to study transient cerebral ischemia. Orthologous to human KLF5 (KLF transcription factor 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Lung (RPKM 73.0), Muscle (RPKM 30.3) and 8 other tissues See more
Orthologs
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Genomic context

See Klf5 in Genome Data Viewer
Location:
15q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (82472081..82487267)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (76060320..76079445)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (83703796..83722921)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene bora, aurora kinase A activator Neighboring gene Spi-C transcription factor, pseudogene 2 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene serpin family B member 6 like, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling via exosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to peptide IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within intestinal epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myotube differentiation involved in skeletal muscle regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by transcription factor localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of regulation of microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within satellite cell activation involved in skeletal muscle regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal muscle satellite cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal muscle tissue regeneration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Krueppel-like factor 5
Names
Kruppel-like factor 5 (intestinal)
basic transcription element binding protein 2
basic transcription element binding protein BTEB2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053394.3NP_445846.3  Krueppel-like factor 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    F1LSL7, Q66HP1
    Related
    ENSRNOP00000054653.2, ENSRNOT00000057843.4
    Conserved Domains (5) summary
    COG5048
    Location:345419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:361383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:419441
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:405430
    zf-H2C2_2; Zinc-finger double domain
    cd21579
    Location:3356
    KLF5_N; N-terminal domain of Kruppel-like factor 5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    82472081..82487267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)