Gfra3 GDNF family receptor alpha 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gfra3provided by RGD
Official Full Name: GDNF family receptor alpha 3provided by RGD
Primary source: RGD:620502
See related: EnsemblRapid:ENSRNOG00000020309 AllianceGenome:RGD:620502
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable axon guidance receptor activity and glial cell-derived neurotrophic factor receptor activity. Predicted to be involved in glial cell-derived neurotrophic factor receptor signaling pathway and nervous system development. Predicted to act upstream of or within axon guidance; neuron migration; and sympathetic nervous system development. Predicted to be located in cytosol. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Biomarker of sciatic neuropathy. Orthologous to human GFRA3 (GDNF family receptor alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 134.3), Thymus (RPKM 34.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (26571952..26600225, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (26297828..26326105, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (27491860..27520133, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that ARTN-GFRalpha3 interactions partially mediate early stage nociceptive signalling following an inflammatory insult.
Title: Artemin-GFRα3 interactions partially contribute to acute inflammatory hypersensitivity.
In the rat, GFRalpha3- and RET-like staining were found in the same non-neural cell type only in kidney.
Title: Distribution of GDNF family receptor alpha3 and RET in rat and human non-neural tissues.
GFRalpha3-labeled fibers were in lamina I, the lateral-collateral pathway, and areas surrounding dorsal groups of preganglionic neurons and associated interneurons.
Title: Expression of receptors for glial cell line-derived neurotrophic factor family ligands in sacral spinal cord reveals separate targets of pelvic afferent fibers.

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General gene information

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Markers

D18Got34 (e-PCR)
- UniSTS:113309

RH128908 (e-PCR)
- UniSTS:212216

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables axon guidance receptor activity	ISO Inferred from Sequence Orthology more info
enables glial cell-derived neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sympathetic nervous system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GDNF family receptor alpha-3

Names: glial cell line derived neurotrophic factor family receptor alpha 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.