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VP2 vacuolar H+-pyrophosphatase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 844231, updated on 15-Feb-2024

Summary

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Gene symbol
VP2
Gene description
vacuolar H+-pyrophosphatase 2
Primary source
Araport:AT1G78920
Locus tag
AT1G78920
See related
TAIR:AT1G78920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtVHP2;1; AVP2; AVPL1; F9K20.2; F9K20_2; vacuolar H+-pyrophosphatase 2; VACUOLAR-PYROPHOSPHATASE LIKE PROTEIN 1; VACUOLAR-TYPE H+-TRANSLOCATING INORGANIC PYROPHOSPHATASE; VHP2;1
Summary
Encodes a type II H+-PPases that localizes to and function as a proton pump of the Golgi apparatus in most tissues except for mature leaves.
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Genomic context

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See VP2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
17
Sequence:
Chromosome: 1; NC_003070.9 (29671413..29677537)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pseudouridine synthase family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene kinase with adenine nucleotide alpha hydrolases-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel type Arabidopsis thaliana H(+)-PPase is localized to the Golgi apparatus. Mitsuda N, et al. FEBS Lett, 2001 Jan 12. PMID 11163790
  2. AVP2, a sequence-divergent, K(+)-insensitive H(+)-translocating inorganic pyrophosphatase from Arabidopsis. Drozdowicz YM, et al. Plant Physiol, 2000 May. PMID 10806252, Free PMC Article
  3. Quantification, organ-specific accumulation and intracellular localization of type II H(+)-pyrophosphatase in Arabidopsis thaliana. Segami S, et al. Plant Cell Physiol, 2010 Aug. PMID 20605924
  4. Label-free protein quantification for plant Golgi protein localization and abundance. Nikolovski N, et al. Plant Physiol, 2014 Oct. PMID 25122472, Free PMC Article
  5. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The type II H(+)-PPase functions as a proton pump in the Golgi and related vesicles in young tissues [VHP2;1]
    Title: Quantification, organ-specific accumulation and intracellular localization of type II H(+)-pyrophosphatase in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001124147.1
NM_001334854.1
NM_106541.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables diphosphate hydrolysis-driven proton transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diphosphate hydrolysis-driven proton transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables inorganic diphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
colocalizes_with Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi cis cisterna HDA PubMed 
located_in endosome HDA PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  
located_in trans-Golgi network HDA PubMed 
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
vacuolar H+-pyrophosphatase 2
NP_001117619.1
  • vacuolar H+-pyrophosphatase 2 (VP2); FUNCTIONS IN: hydrogen-translocating pyrophosphatase activity; INVOLVED IN: proton transport; LOCATED IN: Golgi apparatus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inorganic H+ pyrophosphatase (InterPro:IPR004131); BEST Arabidopsis thaliana protein match is: Inorganic H pyrophosphatase family protein (TAIR:AT1G16780.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_565195.1
  • vacuolar H+-pyrophosphatase 2 (VP2); FUNCTIONS IN: hydrogen-translocating pyrophosphatase activity; INVOLVED IN: proton transport; LOCATED IN: Golgi apparatus, vacuole; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inorganic H+ pyrophosphatase (InterPro:IPR004131); BEST Arabidopsis thaliana protein match is: Inorganic H pyrophosphatase family protein (TAIR:AT1G16780.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    29671413..29677537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106541.4 → NP_565195.1  vacuolar H+-pyrophosphatase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565195.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q56ZN6, Q9LDJ4, Q9MB70, Q9ZVB1
    UniProtKB/TrEMBL
    A0A178WC99, A0A5S9WVL1
    Conserved Domains (1) summary
    PLN02277
    Location:73 → 802
    PLN02277; H(+) -translocating inorganic pyrophosphatase

  2. NM_001124147.1 → NP_001117619.1  vacuolar H+-pyrophosphatase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001117619.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q56ZN6, Q9LDJ4, Q9MB70, Q9ZVB1
    UniProtKB/TrEMBL
    A0A178WC99, A0A5S9WVL1
    Conserved Domains (1) summary
    PLN02277
    Location:73 → 802
    PLN02277; H(+) -translocating inorganic pyrophosphatase

  3. NM_001334854.1 → NP_001322698.1  vacuolar H+-pyrophosphatase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q56ZN6, Q9LDJ4, Q9MB70, Q9ZVB1
    UniProtKB/TrEMBL
    A0A178WC99, A0A5S9WVL1
    Conserved Domains (1) summary
    PLN02277
    Location:73 → 802
    PLN02277; H(+) -translocating inorganic pyrophosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56ZN6.2

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