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HAC1 histone acetyltransferase of the CBP family 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 844241, updated on 18-Sep-2024

Summary

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Official Symbol
HAC1
Official Full Name
histone acetyltransferase of the CBP family 1
Primary source
TAIR:AT1G79000
Locus tag
AT1G79000
See related
Araport:AT1G79000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS HISTONE ACETYLTRANSFERASE OF THE CBP FAMILY 1; ARABIDOPSIS THALIANA P300/CBP ACETYLTRANSFERASE-RELATED PROTEIN 2; ATHAC1; ATHPCAT2; histone acetyltransferase of the CBP family 1; P300/CBP ACETYLTRANSFERASE-RELATED PROTEIN 2; PCAT2; YUP8H12R.38; YUP8H12R_38
Summary
Homologous to CREB-binding protein, a co-activator of transcription with histone acetyl-transferase activity. No single prior lysine acetylation is sufficient to block HAC1 acetylation of the H3 or H4 peptides, suggesting that HAC1, HAC5, and HAC12 can acetylate any of several lysines present in the peptides. HAM2 acetylates histone H4 lysine 5. A plant line expressing an RNAi construct targeted against HAC1 has reduced rates of agrobacterium-mediated root transformation.
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Genomic context

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See HAC1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
18
Sequence:
Chromosome: 1; NC_003070.9 (29716350..29724748, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene uncharacterized protein Neighboring gene Alpha-helical ferredoxin Neighboring gene Enhancer of polycomb-like transcription factor protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeted expression of the arsenate reductase HAC1 identifies cell type specificity of arsenic metabolism and transport in plant roots. Fischer S, et al. J Exp Bot, 2021 Feb 2. PMID 33038235, Free PMC Article
  2. Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins. Bordoli L, et al. Nucleic Acids Res, 2001 Feb 1. PMID 11160878, Free PMC Article
  3. LEUNIG_HOMOLOG Mediates MYC2-Dependent Transcriptional Activation in Cooperation with the Coactivators HAC1 and MED25. You Y, et al. Plant Cell, 2019 Sep. PMID 31320481, Free PMC Article
  4. Role of plant CBP/p300-like genes in the regulation of flowering time. Han SK, et al. Plant J, 2007 Jan. PMID 17144897
  5. The CBP/p300 histone acetyltransferases function as plant-specific MEDIATOR subunits in Arabidopsis. Guo J, et al. J Integr Plant Biol, 2021 Apr. PMID 33325122

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001198504.2
NM_001334866.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-mediated transformation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within flower development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within photoperiodism, flowering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of mediator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
histone acetyltransferase of the CBP family 1
NP_001185433.1
  • histone acetyltransferase of the CBP family 1 (HAC1); FUNCTIONS IN: histone acetyltransferase activity, transcription cofactor activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Histone H3-K56 acetyltransferase, RTT109 (InterPro:IPR013178), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, TAZ-type (InterPro:IPR000197), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the CBP family 12 (TAIR:AT1G16710.1).
NP_565197.3
  • histone acetyltransferase of the CBP family 1 (HAC1); FUNCTIONS IN: histone acetyltransferase activity, transcription cofactor activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Histone H3-K56 acetyltransferase, RTT109 (InterPro:IPR013178), Zinc finger, TAZ-type (InterPro:IPR000197), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the CBP family 12 (TAIR:AT1G16710.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    29716350..29724748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106550.4 → NP_565197.3  histone acetyltransferase of the CBP family 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565197.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64548, Q9C5X9
    UniProtKB/TrEMBL
    A0A178WJZ4, A0A5S9WVM3
    Conserved Domains (4) summary
    smart00551
    Location:631 → 709
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1522 → 1567
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15614
    Location:991 → 1063
    PHD_HAC_like; PHD finger found in Arabidopsis thaliana histone acetyltransferases (HATs) HAC and similar proteins
    cl02120
    Location:1122 → 1343
    HAT_KAT11; Histone acetylation protein

  2. NM_001198504.2 → NP_001185433.1  histone acetyltransferase of the CBP family 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185433.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9WVM3, A0A654F157, F4IDH2
    Conserved Domains (4) summary
    smart00551
    Location:631 → 709
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1522 → 1567
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15614
    Location:991 → 1063
    PHD_HAC_like; PHD finger found in Arabidopsis thaliana histone acetyltransferases (HATs) HAC and similar proteins
    cl02120
    Location:1122 → 1360
    HAT_KAT11; Histone acetylation protein

  3. NM_001334866.1 → NP_001322202.1  histone acetyltransferase of the CBP family 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ATA1, A0A5S9WVM3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C5X9.2

Gene LinkOut

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