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RGLG4 Ca(2)-dependent phospholipid-binding protein (Copine) family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 844276, updated on 18-Sep-2024

Summary

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Official Symbol
RGLG4
Official Full Name
Ca(2)-dependent phospholipid-binding protein (Copine) family
Primary source
TAIR:AT1G79380
Locus tag
AT1G79380
See related
Araport:AT1G79380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
RING DOMAIN LIGASE 4; T8K14.20; T8K14_20
Summary
Encodes a ubiquitin ligase that is an essential upstream modulator of JA signaling in response to various stimuli.
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Genomic context

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See RGLG4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Sequence:
Chromosome: 1; NC_003070.9 (29860491..29863316)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene organic cation/carnitine transporter 2 Neighboring gene cytochrome P450, family 79, subfamily C, polypeptide 1 Neighboring gene centrosomal protein Neighboring gene cation/H+ exchanger 2 Neighboring gene organic cation/carnitine transporter5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4. Zhang X, et al. J Exp Bot, 2015 May. PMID 25788731, Free PMC Article
  2. Two novel RING-type ubiquitin ligases, RGLG3 and RGLG4, are essential for jasmonate-mediated responses in Arabidopsis. Zhang X, et al. Plant Physiol, 2012 Oct. PMID 22898498, Free PMC Article
  3. The Arabidopsis Iron-Sulfur Protein GRXS17 is a Target of the Ubiquitin E3 Ligases RGLG3 and RGLG4. Nagels Durand A, et al. Plant Cell Physiol, 2016 Sep. PMID 27497447
  4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GRXS17 is ubiquitinated and degraded in a proteasome-dependent manner by RGLG3 and RGLG4.
    Title: The Arabidopsis Iron-Sulfur Protein GRXS17 is a Target of the Ubiquitin E3 Ligases RGLG3 and RGLG4.
  2. RGLG3 and RGLG4 have coordinated and positive roles in mycotoxin fumonisin B1 (FB1)-elicited programmed cell death. [RGLG4]
    Title: Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4.
  3. RGLG3 and RGLG4 are essential upstream modulators of jasmonate signaling in response to various stimuli.
    Title: Two novel RING-type ubiquitin ligases, RGLG3 and RGLG4, are essential for jasmonate-mediated responses in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_106586.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within jasmonic acid mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ca(2)-dependent phospholipid-binding protein (Copine) family
NP_565206.1
  • Ca(2)-dependent phospholipid-binding protein (Copine) family; FUNCTIONS IN: zinc ion binding; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase2 (TAIR:AT5G14420.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    29860491..29863316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106586.4 → NP_565206.1  Ca(2)-dependent phospholipid-binding protein (Copine) family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565206.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SAL0
    UniProtKB/TrEMBL
    A0A178W3R7, A0A654EQB6
    Conserved Domains (2) summary
    pfam07002
    Location:102 → 318
    Copine
    cd16729
    Location:357 → 400
    RING-HC_RGLG_plant; RING finger, HC subclass, found in RING domain ligase RGLG1, RGLG2 and similar proteins from plant
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SAL0.1

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