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MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils [ Homo sapiens (human) ]

Gene ID: 84437, updated on 5-Mar-2024

Summary

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Official Symbol
MSANTD4provided by HGNC
Official Full Name
Myb/SANT DNA binding domain containing 4 with coiled-coilsprovided by HGNC
Primary source
HGNC:HGNC:29383
See related
Ensembl:ENSG00000170903 AllianceGenome:HGNC:29383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1826
Summary
Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 8.0), thyroid (RPKM 6.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (106007899..106022287, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (106012491..106026880, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (105878626..105893014, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor AMPA type subunit 4 Neighboring gene RNA, U4 small nuclear 55, pseudogene Neighboring gene uncharacterized LOC124902743 Neighboring gene RNA, U6 small nuclear 277, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5468 Neighboring gene kelch repeat and BTB domain containing 3 Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
  2. PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. Adhikari B, et al. Nat Chem Biol, 2020 Nov. PMID 32989298, Free PMC Article
  3. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article
  4. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article
  5. From ORFeome to biology: a functional genomics pipeline. Wiemann S, et al. Genome Res, 2004 Oct. PMID 15489336, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1826

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
myb/SANT-like DNA-binding domain-containing protein 4
Names
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318747.1 → NP_001305676.1  myb/SANT-like DNA-binding domain-containing protein 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AB058729, AI127319, AP000813, DA758665, DA796698
    Consensus CDS
    CCDS31663.1
    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
    Conserved Domains (2) summary
    COG1196
    Location:209 → 341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13873
    Location:8 → 86
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

  2. NM_001318748.1 → NP_001305677.1  myb/SANT-like DNA-binding domain-containing protein 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AB058729, AI127319, AP000813, DA448146, DA796698
    Consensus CDS
    CCDS31663.1
    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
    Conserved Domains (2) summary
    COG1196
    Location:209 → 341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13873
    Location:8 → 86
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

  3. NM_001318749.1 → NP_001305678.1  myb/SANT-like DNA-binding domain-containing protein 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AI127319, AP000813, BC041118, DA529795, DA796698
    Consensus CDS
    CCDS31663.1
    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
    Conserved Domains (2) summary
    COG1196
    Location:209 → 341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13873
    Location:8 → 86
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

  4. NM_001318750.1 → NP_001305679.1  myb/SANT-like DNA-binding domain-containing protein 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AI127319, AP000813, BC041118, DA796698
    Consensus CDS
    CCDS31663.1
    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
    Conserved Domains (2) summary
    COG1196
    Location:209 → 341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13873
    Location:8 → 86
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

  5. NM_032424.3 → NP_115800.1  myb/SANT-like DNA-binding domain-containing protein 4

    See identical proteins and their annotated locations for NP_115800.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AB058729, AI127319, AP000813, DA796698
    Consensus CDS
    CCDS31663.1
    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
    Related
    ENSP00000304713.4, ENST00000301919.9
    Conserved Domains (2) summary
    COG1196
    Location:209 → 341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13873
    Location:8 → 86
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    106007899..106022287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427709.1 → XP_047283665.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4

  2. XM_017018416.2 → XP_016873905.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
    Conserved Domains (2) summary
    COG1196
    Location:209 → 341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13873
    Location:8 → 86
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

  3. XM_017018417.2 → XP_016873906.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
    Conserved Domains (2) summary
    COG1196
    Location:209 → 341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13873
    Location:8 → 86
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

  4. XM_011543022.4 → XP_011541324.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011541324.1

    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
    Conserved Domains (2) summary
    COG1196
    Location:209 → 341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13873
    Location:8 → 86
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    106012491..106026880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370187.1 → XP_054226162.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4

  2. XM_054370186.1 → XP_054226161.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4

  3. XM_054370185.1 → XP_054226160.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4

  4. XM_054370188.1 → XP_054226163.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCY6.1 GenPept UniProtKB/Swiss-Prot:Q8NCY6

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