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ZNF333 zinc finger protein 333 [ Homo sapiens (human) ]

Gene ID: 84449, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF333provided by HGNC
Official Full Name
zinc finger protein 333provided by HGNC
Primary source
HGNC:HGNC:15624
See related
Ensembl:ENSG00000160961 MIM:611811; AllianceGenome:HGNC:15624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in appendix (RPKM 2.4), endometrium (RPKM 2.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF333 in Genome Data Viewer
Location:
19p13.12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14689787..14733742)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14816091..14860049)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14800860..14844554)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E3 Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene YPEL5 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10263 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:14841378-14842577 Neighboring gene adhesion G protein-coupled receptor E2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14869525-14870048 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14870049-14870574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14884311-14884812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14179 Neighboring gene CRISPRi-validated cis-regulatory element chr19.2424 Neighboring gene TMEM167A pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:14910875-14912074 Neighboring gene olfactory receptor family 7 subfamily C member 1 Neighboring gene olfactory receptor family 7 subfamily A member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1. Tian Y, et al. Biochim Biophys Acta, 2002 Aug 19. PMID 12151103
  2. Identification of the DNA binding element of the human ZNF333 protein. Jing Z, et al. J Biochem Mol Biol, 2004 Nov 30. PMID 15607024
  3. Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin. Oh Y, et al. Cell Mol Biol Lett, 2007. PMID 17607528, Free PMC Article
  4. The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification. Helleboid PY, et al. EMBO J, 2019 Sep 16. PMID 31403225, Free PMC Article
  5. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. Fernandez J, et al. J Biol Chem, 2015 Feb 20. PMID 25505242, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF333 recognized the specific DNA core binding sequence ATAAT
    Title: Identification of the DNA binding element of the human ZNF333 protein.
  2. dna sequence analysis of ZNF333 gene located on chromosome 19p13.1
    Title: Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular zinc finger protein 333 (ZNF333) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1806

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 333

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300912.2 → NP_001287841.1  zinc finger protein 333 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC090427, AF372702, BC048107, DA103403
    Consensus CDS
    CCDS74298.1
    UniProtKB/Swiss-Prot
    Q96JL9
    Related
    ENSP00000438130.1, ENST00000540689.6
    Conserved Domains (2) summary
    smart00349
    Location:203 → 263
    KRAB; krueppel associated box
    pfam01352
    Location:203 → 242
    KRAB; KRAB box

  2. NM_001352239.2 → NP_001339168.1  zinc finger protein 333 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090427, AF372702, BP231733, DA103403, HY032449
    UniProtKB/TrEMBL
    B3KSN8
    Conserved Domains (5) summary
    smart00349
    Location:94 → 154
    KRAB; krueppel associated box
    COG5048
    Location:119 → 416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:315 → 335
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:509 → 531
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:440 → 463
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001352240.2 → NP_001339169.1  zinc finger protein 333 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090427, AF372702, BP231733, DA103403, DC335178, HY032449
    UniProtKB/TrEMBL
    B3KSN8
    Conserved Domains (5) summary
    smart00349
    Location:94 → 154
    KRAB; krueppel associated box
    COG5048
    Location:119 → 416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:315 → 335
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:509 → 531
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:440 → 463
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001352241.2 → NP_001339170.1  zinc finger protein 333 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090427, AF372702, DA103403, DA248936
    Conserved Domains (4) summary
    smart00349
    Location:57 → 117
    KRAB; krueppel associated box
    COG5048
    Location:211 → 379
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:278 → 298
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:403 → 426
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001352243.2 → NP_001339172.1  zinc finger protein 333 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090427, AF372702, DA103403
    Conserved Domains (4) summary
    COG5048
    Location:126 → 294
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:193 → 213
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:318 → 341
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  6. NM_001352244.2 → NP_001339173.1  zinc finger protein 333 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090427, AF372702, DA103403
    Conserved Domains (1) summary
    smart00349
    Location:203 → 263
    KRAB; krueppel associated box

  7. NM_032433.4 → NP_115809.1  zinc finger protein 333 isoform 1

    See identical proteins and their annotated locations for NP_115809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC090427, AF372702, DA103403
    Consensus CDS
    CCDS12316.1
    UniProtKB/Swiss-Prot
    Q6P2E6, Q86WS6, Q8TDL0, Q96JL9
    Related
    ENSP00000292530.5, ENST00000292530.11
    Conserved Domains (6) summary
    smart00349
    Location:203 → 263
    KRAB; krueppel associated box
    COG5048
    Location:228 → 525
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:424 → 444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:394 → 416
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:203 → 242
    KRAB; KRAB box
    pfam13465
    Location:408 → 433
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    14689787..14733742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528362.3 → XP_011526664.1  zinc finger protein 333 isoform X1

    See identical proteins and their annotated locations for XP_011526664.1

    UniProtKB/Swiss-Prot
    Q6P2E6, Q86WS6, Q8TDL0, Q96JL9
    Conserved Domains (6) summary
    smart00349
    Location:203 → 263
    KRAB; krueppel associated box
    COG5048
    Location:228 → 525
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:424 → 444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:394 → 416
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:203 → 242
    KRAB; KRAB box
    pfam13465
    Location:408 → 433
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047439519.1 → XP_047295475.1  zinc finger protein 333 isoform X2

    UniProtKB/TrEMBL
    B3KSN8

  3. XM_047439518.1 → XP_047295474.1  zinc finger protein 333 isoform X2

    UniProtKB/TrEMBL
    B3KSN8

  4. XM_011528371.3 → XP_011526673.1  zinc finger protein 333 isoform X3

    Conserved Domains (6) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:168 → 336
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:235 → 255
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:205 → 227
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:219 → 244
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    14816091..14860049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322348.1 → XP_054178323.1  zinc finger protein 333 isoform X1

    UniProtKB/Swiss-Prot
    Q6P2E6, Q86WS6, Q8TDL0, Q96JL9

  2. XM_054322349.1 → XP_054178324.1  zinc finger protein 333 isoform X2

    UniProtKB/TrEMBL
    B3KSN8

  3. XM_054322350.1 → XP_054178325.1  zinc finger protein 333 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96JL9.3 GenPept UniProtKB/Swiss-Prot:Q96JL9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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