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ACTRT3 actin related protein T3 [ Homo sapiens (human) ]

Gene ID: 84517, updated on 2-Nov-2024

Summary

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Official Symbol
ACTRT3provided by HGNC
Official Full Name
actin related protein T3provided by HGNC
Primary source
HGNC:HGNC:24022
See related
Ensembl:ENSG00000184378 MIM:608534; AllianceGenome:HGNC:24022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARPM1; ARP-T3
Summary
Predicted to be located in cytoplasm; cytoskeleton; and male germ cell nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 21.9), kidney (RPKM 1.3) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See ACTRT3 in Genome Data Viewer
Location:
3q26.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (169766921..169769561, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (172550873..172553662, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (169484709..169487349, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 637, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20782 Neighboring gene telomerase RNA component (TERC) promoter Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 3:169486144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20783 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 3:169487501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20784 Neighboring gene telomerase RNA component Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:169490847-169491350 Neighboring gene tRNA-Val (anticodon AAC) 1-1 Neighboring gene myoneurin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin. Harata M, et al. Biochim Biophys Acta, 2001 Dec 3. PMID 11750065
  2. Nuclear localization of profilin III-ArpM1 complex in mouse spermiogenesis. Hara Y, et al. FEBS Lett, 2008 Sep 3. PMID 18692047
  3. Identification of a melanoma susceptibility locus and somatic mutation in TET2. Song F, et al. Carcinogenesis, 2014 Sep. PMID 24980573, Free PMC Article
  4. Genome-wide association study identifies multiple loci associated with bladder cancer risk. Figueroa JD, et al. Hum Mol Genet, 2014 Mar 1. PMID 24163127, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
EBI GWAS Catalog
Identification of a melanoma susceptibility locus and somatic mutation in TET2.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC15664

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
actin-related protein T3
Names
actin-related protein M1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032487.5 → NP_115876.3  actin-related protein T3

    See identical proteins and their annotated locations for NP_115876.3

    Status: VALIDATED

    Source sequence(s)
    AB049117, AI811210, AK055346
    Consensus CDS
    CCDS3206.1
    UniProtKB/Swiss-Prot
    Q96IS0, Q96NJ0, Q9BYD9
    Related
    ENSP00000333037.1, ENST00000330368.3
    Conserved Domains (2) summary
    smart00268
    Location:7 → 372
    ACTIN; Actin
    cl17037
    Location:9 → 372
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    169766921..169769561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    172550873..172553662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BYD9.1 GenPept UniProtKB/Swiss-Prot:Q9BYD9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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