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LYZL1 lysozyme like 1 [ Homo sapiens (human) ]

Gene ID: 84569, updated on 3-Apr-2024

Summary

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Official Symbol
LYZL1provided by HGNC
Official Full Name
lysozyme like 1provided by HGNC
Primary source
HGNC:HGNC:30502
See related
Ensembl:ENSG00000120563 AllianceGenome:HGNC:30502
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYC2; LYZD1; KAAG648; PRO1278; bA534G20.1
Summary
Predicted to enable lysozyme activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 12.4) See more
Orthologs
all
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Genomic context

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Location:
10p12.1-p11.23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (29289070..29318328)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (29320734..29350003)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (29577999..29600161)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984171 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:29429294-29429794 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:29429795-29430295 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:29448375-29449050 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:29495743-29495973 Neighboring gene uncharacterized LOC105376472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3194 Neighboring gene OCT4 hESC enhancer GRCh37_chr10:29591323-29591859 Neighboring gene uncharacterized LOC124902400 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:29633052-29634251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:29655033-29655534 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:29655751-29656950 Neighboring gene uncharacterized LOC107984217 Neighboring gene uncharacterized LOC105376473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:29683525-29684039 Neighboring gene uncharacterized LOC105376474

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Wu JH, et al. Circ Cardiovasc Genet, 2013 Apr. PMID 23362303, Free PMC Article
  2. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. Uhl GR, et al. Arch Gen Psychiatry, 2008 Jun. PMID 18519826, Free PMC Article
  3. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33408

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysozyme-like protein 1
Names
lysozyme D1
NP_115906.4
XP_005252684.1
XP_016872280.1
XP_054222932.1
XP_054222933.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032517.6 → NP_115906.4  lysozyme-like protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AI393331, AL158167, BC021730, BF057063, BG209290, BP369317
    Consensus CDS
    CCDS31174.2
    UniProtKB/Swiss-Prot
    Q5T921, Q6UWQ5, Q8WW16
    Related
    ENSP00000498092.1, ENST00000649382.2
    Conserved Domains (1) summary
    cd00119
    Location:20 → 143
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    29289070..29318328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252627.4 → XP_005252684.1  lysozyme-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A080YUZ8
    Related
    ENSP00000364650.3, ENST00000375500.8
    Conserved Domains (1) summary
    cd00119
    Location:66 → 172
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

  2. XM_017016791.2 → XP_016872280.1  lysozyme-like protein 1 isoform X2

RNA

  1. XR_428650.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    29320734..29350003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366957.1 → XP_054222932.1  lysozyme-like protein 1 isoform X1

  2. XM_054366958.1 → XP_054222933.1  lysozyme-like protein 1 isoform X2

RNA

  1. XR_008488300.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UWQ5.2 GenPept UniProtKB/Swiss-Prot:Q6UWQ5

Gene LinkOut

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